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Database: UniProt/TrEMBL
Entry: A0A0D6EDF9_9GAMM
LinkDB: A0A0D6EDF9_9GAMM
Original site: A0A0D6EDF9_9GAMM 
ID   A0A0D6EDF9_9GAMM        Unreviewed;      4085 AA.
AC   A0A0D6EDF9;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   30-AUG-2017, entry version 15.
DE   SubName: Full=Amino acid adenylation {ECO:0000313|EMBL:CEP37349.1};
GN   ORFNames=HALO3667 {ECO:0000313|EMBL:CEP37349.1};
OS   Halomonas sp. R57-5.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1610576 {ECO:0000313|EMBL:CEP37349.1};
RN   [1] {ECO:0000313|EMBL:CEP37349.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R57-5 {ECO:0000313|EMBL:CEP37349.1};
RA   Hjerde Erik;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; LN813019; CEP37349.1; -; Genomic_DNA.
DR   KEGG; ham:HALO3667; -.
DR   PATRIC; fig|1610576.5.peg.3775; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR003819; TauD/TfdA-like.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF02668; TauD; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 3.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     85    104       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      622    696       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     1688   1754       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3185   3252       Carrier. {ECO:0000259|PROSITE:PS50075}.
SQ   SEQUENCE   4085 AA;  450000 MW;  565D8F386C3B11EA CRC64;
     MNIRHAQTMN SHPSHNVVNH SFVEHLSRLA RERPSDRALI VVNAQGETTL DYATLERRSR
     ALASELQQRF PAGERALILL DNDEHYVVAF FACLYAGVIA VPVFPPESAK QQHLARLLAI
     AADSQAACVL TSTTIIDVVA SASEGFGSAE LIPVDAVDES RAEHWIEHRP KRGDLAFLQY
     TSGSTATPKG VMVSHGNLMA NERAIETGFS IGADDVFVSW LPLYHDMGLI GGLLQPIYRG
     IPAVLMSPTF FLQRPVRWLE AISRHRGTIS GGPDFAYRLC LERIRDEQLE ALDLSSWRVA
     FSGAEPVRHD TLTGFIERFR PAGFAADTAA PCYGLAEATL LVSCNSRGTG VVGTAFSQQS
     LAEGKAVSAV EGNTLVGCGT PEPGHAIDIV DPEGLHSLPS GDVGEIWVNG PSVAHGYWQN
     PEATAQAFVT RDGVSWQRTD DADAQNHDAR DDRWLRTGDL GFLHEGQLYI AGRIKDLIIL
     RGHNVYPQDI ESAIEAEVEA VRKGRVAAFA VTTPEGAEGI GVAAEVSRGI QKLVPAEKLV
     EALSETVGSA CHEPLSVVLL LNPGGLPKTS SGKLQRSTCR QGWEAGSLDA YAIHAFGRFV
     SDGDAEGGGK SSPSPAEAGS ETEQALAKLW HQVLGDDDTQ SQSKPLGSDA HFFASGGNSL
     AAVRLAATIS DYWGVELSLH SLFEQPRLSA MAKAIEARLA ASSDQRGMAI PRLEDDQRQG
     DIPLSEGQRS LWLTWQLDPQ SAGYNMAGAL HLKGVLDPSS LNAALEDLVQ RHDILRTYYP
     LSEAGEPVQR LAQDWHPELI CDEMPGDTVD EREQALHDAL TKLARKAFAL DQAPPLTIAL
     YRLSTEHHVL AVVQHHIAGD GWSVQVLIDD LCALYEGACT QQEVKLAPLP VQFADYAVWQ
     QRQKHSSERH SSERQGQLAH WCERLSGDHP PLALPLDRPR QAMSAPSEGQ LRFTLPGELS
     EQLRSLARER NVSLYAVILA LLKQTLYRFS GETDIKVGAP IANRHKAELQ GLIGYLINVV
     VLRTQIDPTG NFERLLDEVN ATLIDAQLHQ DVPFDQVVEA LQLERQPGVH PLFQVKCTQQ
     EMWQAERHVA GLVIQAEQVF TGIAHFDLSL DFCDEPEGIA GLFAYSAELF DATTIERFCQ
     AFRFLAEQVV ADPRSHTAML SLPEPISVLE GNQSEILTQA IPTLLSKVVV AHADELAVND
     GQYRYTYASL DAQAQSLAQA LIAKGVGSEV RVAIHAERSC EYVLGILAVL KAGGAFVPLD
     PQLPRERLAY QLADSGARLM LSSTACDWSD AVPVMELAFX DDVPAAVENK SPVIHLQQTA
     YVIYTSGSTG KPKGVAVSHG ALANYVQGVL EALALPEGAR NMAMVSTVAA DLGHTVLFGA
     LCTGRTLHLI SPECAFDPDA FAAYMREQRV DVLKIVPSHL RALLSAATPA DVLPHERLIL
     GGEATDWALL ERIAELKPTC QVLNHYGPTE TTVGILTQQA DIADRAASTL PIGTPLANAQ
     AWVLDPWLNP VPKGVAGELY LGGPGLAQGY LQRLGQTAER FVASPFHAGE RLYRSGDRVR
     QLADGSLTFL CRVDDQVKIR GYRVEPSEIA TLLRDQPCIA EAEVVARENE EGRAQLFAYV
     VMAAGSDIDD AALLAQLGER VPDYMVPSAI VRLDALPLTA NGKLDRKALP EPVQAGGGKA
     FEAPQGAAEE TLAAVWADVI GCEQVGRNDN FFELGGDSIL SLQIVARSRK RGYKVTPKQL
     MEGQTVAAVA AMATPLAATA PKQAAAPNKA ASFALLPVQR WFFEQNFAEP QHWNQSLMLE
     AASGVDTALL RRAIEAVVDH HSALRLRFER VGDSWQQAYG KLADDLFEHV DVSDHADPAQ
     AITQAADAAQ RSLSLARPFR AIWMALGGER GGRLLLVAHH LVIDGVSWRV ILDDLQAAYA
     QLSAGKTVDL PPATTLLDEW ARALADYAKS EALAEQCSYW ESLVTAPEPS LPARNPHGSN
     TVADTASLVG SLPTEATTQL LGPVHKAYRT QVDDLLLNAL SSALCQWAER DSVLIELEGH
     GREDLFDGID LSRSVGWFTS LYPVRLTPGN AEPGTSLKAI KEQLRQVPEK GLGYGVLRYL
     KEEPALVGGA YPQVTFNYLG QLDRSLQGDG AWRLAKENAG QARAPQSKRR TWIEVVAWVQ
     DGQLRFDWNY SREIHSEAAI HALQVSFQAQ LEALIEHCAS GVRGATPSDF PLAGLSQEQL
     DGLPVDTXQL ADLYPLSPLQ QGMLFHSLYD DQDSAYLNQL QVEIDDLDVK RFQLAWQAVL
     ARHEVLRSGF LESAGMPLQW VARNVDLPWF EVDWRERVDL KAALERLSQE QRKPFDMTAP
     PLMRLALVRI AETRYCFIWT RHHLLLDGWS TSQLMGEVLR CYAGEALPSA EGRYRDYIAW
     LQRRDTNASE TYWRDQLQRL DAPTHLVSTX PRPYEAQAGH QEITLSLDST TTQRLEGFAK
     ATRITLNTLM QGAWALLVAR YTGQDSICFG ATVAGRPAEL PAAENLIGPF INTLPVIVSL
     NPSLRVNEWL CQLQAQNLAS REHEHTPLYE IQRWAGQGGQ ALFDSLVVFE NYPVDAALHQ
     NLPGGLTFGE VDNREQTNYP VTLVVFHKEA LELCCGYSRS QLDDAAAEIL IQHLVGVLKQ
     LSESATRRVG DIDWLSDVEQ QQLETWSVND EHYEWEAPIH RLIERRSDMA PGATALIFDD
     QHLSYAELNT RANRLAHYLI GLGVQPETRV GIAVERSIEM VVGLLSILKA GGAYVPLDPD
     YPSERLAYMV EDSGIELLLT QQHLRNTLPV FESLGVIELD QLDVAHHAST NPEVALHGEH
     LAYVIYTSGS TGRPKGAANR HHALTNRLQW MQDAYGLTTD GAVLQKTPFS FDVSVWEFFW
     PLIQGARLVM APPGAHREPA QLVELIRSHN ITTLHFVPSM LQAFLAHGKV EDCTSLTRLV
     CSGEALPAEL QNQVFARLPH TELYNLYGPT EAAIDVTHWA CQDDGRNHVA IGQPIAGIRT
     YVLDGDLNLA PPGVAGELYL GGIGLARGYL HRPDLTAERF VADPFAQGEC LYRTGDLVRW
     REDGQLEYLG RLDHQVKIRG LRIELGEIEA ELLSQPAVRE AVVVAQEGPG GSRLVAYVVL
     QADSKLDTSS LREALGQRLP DYMVPGVVVT LDTLPLNPNG KVDRKALPEP DLTSGTRYEL
     PQGQSEETLA AIWAEVLGVE RVGRHDNFFE LGGHSLLAMQ VLARIRAAGL HSLALRELFK
     SPVLCELAPL ISTGMNDMAG GEPLTSIPRR EEMPLSPAQK RLWMVDRLAG STRERTAYNM
     STALTLTGRL DAEAIKSTFD VIVDRHEVLR TRYPENEEGE PVAVVASGNP MEVEWVDLVN
     LESNQQSQQA RWLMEEHAQR AFDLSSGPLL RAAVIRLAPR SHLLLLCVHH IVFDGWSEAV
     FIKEFVTTYQ ALIGEGEDVL TDLPIQYVDY AAWHEKALSG EAFEQSATFW RRYLSDAPPL
     STLPGDFARP SQISHAGSAL SMTLSPDLSQ ALNKLAAQRG TTLFTLLLAS FQLLMHRQTR
     QHDLIVGTDV AGRSHPDVEP LIGFFVNVIP LRSRLSDGQI DFGHWLEQVQ TSVLDAFDHQ
     NVPFDKIVEL SGIGRERDRS PLIQTLFVLQ NTPTERFSIP GLEVEVMPQP RQESKFDMAI
     FVNESDTGLS VEWVYATALY RRETIEHLTG AWQSLLAQIV EAPNTPVEEF RLPQMEKHAM
     QNKLSKGSKL NKLSSLKSQP GARPSTNSDS PIRTALLDEK RVFPLVIEAT DPDLDAVAWA
     TSQRDFIEQH LRTHAGILFR NFGLTTPQEF EAFAEAIQPG LYGNYGDLPK KEGGRNTYRS
     TPYPERQMIL YHNESSHLER WPRKQLFFCE FPSPVGGATP IVDCREMLRQ LPADVVEEFE
     RKGLLYVRTF TRNLDVSWQD FFKTDSKEEV EARLKEAGIE WQWFGDDELQ TRTRCPAVVT
     HPVTGDRVFF NQVQLHHVSC LEPDVKEDLL GMVGQERLPR NVYFGDGSVI SDEMMKVVGE
     AYEACAVRFD WRRGDVVMVD NMLAAHARDP YEGPRKIVVA MGDIYERSAL EEAQGASADA
     ELVGQ
//
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