ID A0A0D6FLR9_SALTM Unreviewed; 494 AA.
AC A0A0D6FLR9; A0A0M2IVP2; A0A2J0RDF6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Alpha-amylase {ECO:0000313|EMBL:HAD0380129.1, ECO:0000313|EMBL:KTZ03421.1};
DE EC=3.2.1.1 {ECO:0000313|EMBL:HAD0380129.1, ECO:0000313|EMBL:KTZ03421.1};
GN Name=amyA {ECO:0000313|EMBL:HAD0380129.1};
GN ORFNames=AVC05_18550 {ECO:0000313|EMBL:ECY5343219.1}, B1P38_23970
GN {ECO:0000313|EMBL:ECU8356566.1}, CE70_09740
GN {ECO:0000313|EMBL:ECE0295462.1}, CFF59_05185
GN {ECO:0000313|EMBL:EDI6664657.1}, CVR97_16805
GN {ECO:0000313|EMBL:PJH60808.1}, DD95_24375
GN {ECO:0000313|EMBL:KTZ03421.1}, DMO92_23330
GN {ECO:0000313|EMBL:EBU9274946.1}, DPF41_19545
GN {ECO:0000313|EMBL:EBW3630255.1}, DPS76_24625
GN {ECO:0000313|EMBL:EBW5465574.1}, DRM14_21830
GN {ECO:0000313|EMBL:MLP87907.1}, DU071_21000
GN {ECO:0000313|EMBL:EBY1704375.1}, EER35_17235
GN {ECO:0000313|EMBL:EBZ6922704.1}, F3R12_13460
GN {ECO:0000313|EMBL:ECW0640843.1}, GB466_16400
GN {ECO:0000313|EMBL:HAB0972128.1}, GTH90_18290
GN {ECO:0000313|EMBL:HAD0380129.1};
OS Salmonella typhimurium.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371 {ECO:0000313|EMBL:HAD0380129.1};
RN [1] {ECO:0000313|EMBL:KTZ03421.1, ECO:0000313|Proteomes:UP000054461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N32045 {ECO:0000313|EMBL:KTZ03421.1,
RC ECO:0000313|Proteomes:UP000054461};
RA Chen Y., Folster J., Ayers S., Kabera C., Li C., Mukherjee S., Lam C.,
RA Zhao S., McDermott P.;
RT "Salmonella Genotype and Phenotype Association.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PJH60808.1, ECO:0000313|Proteomes:UP000228538}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N029 {ECO:0000313|EMBL:PJH60808.1,
RC ECO:0000313|Proteomes:UP000228538};
RA Sanad Y., Khajanchi B., Deck J., Cox J., Thaker R., Han J., Nayak R.,
RA Foley S.;
RT "Characterization of the Virulence Potential of Salmonella enterica
RT Isolates Carrying Incompatibility Group FIB Plasmids using Caco-2
RT Intestinal Epithelial Cells.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HAD0380129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Q175F4_TH {ECO:0000313|EMBL:HAD0380129.1}, and Salmonella
RC enterica {ECO:0000313|EMBL:HAB0972128.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:EBU9274946.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=231108 {ECO:0000313|EMBL:EBW3630255.1}, 356083
RC {ECO:0000313|EMBL:EBY1704375.1}, 422529
RC {ECO:0000313|EMBL:EBW5465574.1}, 425567 {ECO:0000313|EMBL:MLP87907.1},
RC 43916 {ECO:0000313|EMBL:ECY5343219.1}, 488670
RC {ECO:0000313|EMBL:EBU9274946.1}, and 632340
RC {ECO:0000313|EMBL:EBZ6922704.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:EDI6664657.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PNUSAS008736 {ECO:0000313|EMBL:ECU8356566.1}, and PNUSAS016739
RC {ECO:0000313|EMBL:EDI6664657.1};
RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:HAD0380129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Q175F4_TH {ECO:0000313|EMBL:HAD0380129.1}, and Salmonella
RC enterica {ECO:0000313|EMBL:HAB0972128.1};
RG NCBI Pathogen Detection Project;
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:ECW0640843.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00020735 {ECO:0000313|EMBL:ECW0640843.1}, and
RC VA_WGS-00080 {ECO:0000313|EMBL:ECE0295462.1,
RC ECO:0000313|Proteomes:UP000338496};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC {ECO:0000256|ARBA:ARBA00008061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:HAD0380129.1}.
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DR EMBL; AAHDPU010000035; EBU9274946.1; -; Genomic_DNA.
DR EMBL; AAHIDF010000028; EBW3630255.1; -; Genomic_DNA.
DR EMBL; AAHIPE010000057; EBW5465574.1; -; Genomic_DNA.
DR EMBL; AAHNIA010000052; EBY1704375.1; -; Genomic_DNA.
DR EMBL; AAHRYM010000024; EBZ6922704.1; -; Genomic_DNA.
DR EMBL; AAIGQE010000005; ECE0295462.1; -; Genomic_DNA.
DR EMBL; AAKRET010000038; ECU8356566.1; -; Genomic_DNA.
DR EMBL; AAKVET010000008; ECW0640843.1; -; Genomic_DNA.
DR EMBL; AALDNI010000045; ECY5343219.1; -; Genomic_DNA.
DR EMBL; AAMLUT010000002; EDI6664657.1; -; Genomic_DNA.
DR EMBL; DAAFPQ010000012; HAB0972128.1; -; Genomic_DNA.
DR EMBL; DAANLN010000034; HAD0380129.1; -; Genomic_DNA.
DR EMBL; JYVU01000113; KTZ03421.1; -; Genomic_DNA.
DR EMBL; RVDJ01000029; MLP87907.1; -; Genomic_DNA.
DR EMBL; PHGX01000051; PJH60808.1; -; Genomic_DNA.
DR RefSeq; WP_000795487.1; NZ_WXYU01000004.1.
DR KEGG; seni:CY43_10340; -.
DR eggNOG; COG0366; Bacteria.
DR OMA; FFHWYYP; -.
DR Proteomes; UP000054461; Unassembled WGS sequence.
DR Proteomes; UP000228538; Unassembled WGS sequence.
DR Proteomes; UP000338496; Unassembled WGS sequence.
DR Proteomes; UP000839616; Unassembled WGS sequence.
DR Proteomes; UP000839617; Unassembled WGS sequence.
DR Proteomes; UP000839905; Unassembled WGS sequence.
DR Proteomes; UP000839907; Unassembled WGS sequence.
DR Proteomes; UP000839908; Unassembled WGS sequence.
DR Proteomes; UP000839909; Unassembled WGS sequence.
DR Proteomes; UP000839911; Unassembled WGS sequence.
DR Proteomes; UP000839914; Unassembled WGS sequence.
DR Proteomes; UP000839915; Unassembled WGS sequence.
DR Proteomes; UP000885385; Unassembled WGS sequence.
DR GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd11318; AmyAc_bac_fung_AmyA; 1.
DR Gene3D; 2.40.30.140; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013776; A-amylase_thermo.
DR InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR PANTHER; PTHR43447:SF7; ALPHA-AMYLASE 2-RELATED; 1.
DR Pfam; PF00128; Alpha-amylase; 1.
DR PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR SMART; SM00642; Aamy; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR001021-2};
KW Glycosidase {ECO:0000313|EMBL:HAD0380129.1};
KW Hydrolase {ECO:0000313|EMBL:HAD0380129.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001021-2}.
FT DOMAIN 4..402
FT /note="Glycosyl hydrolase family 13 catalytic"
FT /evidence="ECO:0000259|SMART:SM00642"
FT ACT_SITE 235
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-1"
FT ACT_SITE 265
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-1"
FT BINDING 104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-2"
FT BINDING 198
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-2"
FT BINDING 206
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-2"
FT BINDING 239
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR001021-2"
SQ SEQUENCE 494 AA; 56522 MW; 5C1E862FEDD5E47C CRC64;
MKNPTLLQYF HWYYPDGGKL WSELAERADG LNDIGINMVW LPPACKGASG GYSVGYDTYD
LFDLGEFDQK GTIATKYGDK RQLLTAIDAL KKNNIAVLLD VVVNHKMGAD EKERIRVQRV
NQDDRTQIDD NIIECEGWTR YTFPARAGQY SNFIWDYHCF SGIDHIENPD EDGIFKIVND
YTGDGWNDQV DDEMGNFDYL MGENIDFRNH AVTEEIKYWA RWVMEQTHCD GFRLDAVKHI
PAWFYKEWIE HVQAVAPKPL FIVAEYWSHE VDKLQTYIDQ VDGKTMLFDA PLQMKFHEAS
RQGAEYDMRH IFTGTLVEAD PFHAVTLVAN HDTQPLQALE APVEPWFKPL AYALILLREN
GVPSVFYPDL YGASYEDSGE NGETCRVDMP VINQLDRLIL ARQRFAHGIQ TLFFDHPNCI
AFSRSGTEEN PGCVVVLSNG DDGEKTLLLG DNYANKTWRD FLGNRDEYVV TNDQGEATFF
CNAGSVSVWV IEDV
//