UniProt/TrEMBL: A0A0D6H0V3

Database: UniProt/TrEMBL
Entry: A0A0D6H0V3_SALTM

LinkDB:  A0A0D6H0V3_SALTM 
Original site:  A0A0D6H0V3_SALTM

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   EMBL (19)   
Protein domain (12)   
   InterPro (7)   
   Pfam (4)   
   SMART (1)   
Literature (2)   
   PubMed (2)   
All databases (39)   

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ID   A0A0D6H0V3_SALTM        Unreviewed;       933 AA.
AC   A0A0D6H0V3; A0A0F7J779; A0A0M2IYD9; A0A3Y9F3G8;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   Name=sucA {ECO:0000313|EMBL:HAD1212665.1};
GN   Synonyms=kgd {ECO:0000313|EMBL:AKH06399.1};
GN   ORFNames=AAB27_22595 {ECO:0000313|EMBL:ECV8763665.1}, AU613_23955
GN   {ECO:0000313|EMBL:MIT51899.1}, AVC05_19140
GN   {ECO:0000313|EMBL:ECY5343333.1}, B1P38_06465
GN   {ECO:0000313|EMBL:ECU8353241.1}, CE70_09935
GN   {ECO:0000313|EMBL:ECE0295494.1}, CFF59_22780
GN   {ECO:0000313|EMBL:EDI6668063.1}, CVR97_21730
GN   {ECO:0000313|EMBL:PJH59926.1}, DD95_16155
GN   {ECO:0000313|EMBL:KTZ10128.1}, DMO92_00070
GN   {ECO:0000313|EMBL:EBU9270511.1}, DPF41_17970
GN   {ECO:0000313|EMBL:EBW3629954.1}, DPS76_19315
GN   {ECO:0000313|EMBL:EBW5464561.1}, DRM14_19295
GN   {ECO:0000313|EMBL:MLP87429.1}, DU071_22690
GN   {ECO:0000313|EMBL:EBY1704698.1}, E0935_24535
GN   {ECO:0000313|EMBL:ECF1546393.1}, EER35_15580
GN   {ECO:0000313|EMBL:EBZ6922377.1}, F3R12_17625
GN   {ECO:0000313|EMBL:ECW0641627.1}, G0P31_14740
GN   {ECO:0000313|EMBL:HAD1212665.1}, GB466_21185
GN   {ECO:0000313|EMBL:HAB0973040.1}, SE14_00820
GN   {ECO:0000313|EMBL:AKH06399.1};
OS   Salmonella typhimurium.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371 {ECO:0000313|EMBL:HAD1212665.1};
RN   [1] {ECO:0000313|EMBL:KTZ10128.1, ECO:0000313|Proteomes:UP000054461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CVM N32045 {ECO:0000313|EMBL:KTZ10128.1,
RC   ECO:0000313|Proteomes:UP000054461};
RA   Chen Y., Folster J., Ayers S., Kabera C., Li C., Mukherjee S., Lam C.,
RA   Zhao S., McDermott P.;
RT   "Salmonella Genotype and Phenotype Association.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AKH06399.1, ECO:0000313|Proteomes:UP000034636}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YU39 {ECO:0000313|EMBL:AKH06399.1,
RC   ECO:0000313|Proteomes:UP000034636};
RX   PubMed=26089426;
RA   Calva E., Silva C., Zaidi M.B., Sanchez-Flores A., Estrada K., Silva G.G.,
RA   Soto-Jimenez L.M., Wiesner M., Fernandez-Mora M., Edwards R.A., Vinuesa P.;
RT   "Complete Genome Sequencing of a Multidrug-Resistant and Human-Invasive
RT   Salmonella enterica Serovar Typhimurium Strain of the Emerging Sequence
RT   Type 213 Genotype.";
RL   Genome Announc. 3:e00663-15(2015).
RN   [3] {ECO:0000313|EMBL:PJH59926.1, ECO:0000313|Proteomes:UP000228538}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N029 {ECO:0000313|EMBL:PJH59926.1,
RC   ECO:0000313|Proteomes:UP000228538};
RA   Sanad Y., Khajanchi B., Deck J., Cox J., Thaker R., Han J., Nayak R.,
RA   Foley S.;
RT   "Characterization of the Virulence Potential of Salmonella enterica
RT   Isolates Carrying Incompatibility Group FIB Plasmids using Caco-2
RT   Intestinal Epithelial Cells.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:HAD1212665.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0973040.1}, and
RC   SSI_AA636 {ECO:0000313|EMBL:HAD1212665.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [5] {ECO:0000313|EMBL:ECE0295494.1, ECO:0000313|Proteomes:UP000338496}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AUSMDU00020735 {ECO:0000313|EMBL:ECW0641627.1}, and
RC   VA_WGS-00080 {ECO:0000313|EMBL:ECE0295494.1,
RC   ECO:0000313|Proteomes:UP000338496};
RG   GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:EDI6668063.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PNUSAS008736 {ECO:0000313|EMBL:ECU8353241.1}, and PNUSAS016739
RC   {ECO:0000313|EMBL:EDI6668063.1};
RG   PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA   Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA   Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:EBY1704698.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=231108 {ECO:0000313|EMBL:EBW3629954.1}, 265852
RC   {ECO:0000313|EMBL:ECF1546393.1}, 29290 {ECO:0000313|EMBL:MIT51899.1},
RC   356083 {ECO:0000313|EMBL:EBY1704698.1}, 422529
RC   {ECO:0000313|EMBL:EBW5464561.1}, 425567 {ECO:0000313|EMBL:MLP87429.1},
RC   43916 {ECO:0000313|EMBL:ECY5343333.1}, 488670
RC   {ECO:0000313|EMBL:EBU9270511.1}, 632340
RC   {ECO:0000313|EMBL:EBZ6922377.1}, and 86846
RC   {ECO:0000313|EMBL:ECV8763665.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:HAD1212665.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0973040.1}, and
RC   SSI_AA636 {ECO:0000313|EMBL:HAD1212665.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E1 component of the 2-oxoglutarate dehydrogenase (OGDH)
CC       complex which catalyzes the decarboxylation of 2-oxoglutarate, the
CC       first step in the conversion of 2-oxoglutarate to succinyl-CoA and
CC       CO(2). {ECO:0000256|ARBA:ARBA00003906}.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP011428; AKH06399.1; -; Genomic_DNA.
DR   EMBL; AAHDPU010000001; EBU9270511.1; -; Genomic_DNA.
DR   EMBL; AAHIDF010000024; EBW3629954.1; -; Genomic_DNA.
DR   EMBL; AAHIPE010000025; EBW5464561.1; -; Genomic_DNA.
DR   EMBL; AAHNIA010000064; EBY1704698.1; -; Genomic_DNA.
DR   EMBL; AAHRYM010000020; EBZ6922377.1; -; Genomic_DNA.
DR   EMBL; AAIGQE010000006; ECE0295494.1; -; Genomic_DNA.
DR   EMBL; AAIKGB010000043; ECF1546393.1; -; Genomic_DNA.
DR   EMBL; AAKRET010000005; ECU8353241.1; -; Genomic_DNA.
DR   EMBL; AAKUOT010000073; ECV8763665.1; -; Genomic_DNA.
DR   EMBL; AAKVET010000015; ECW0641627.1; -; Genomic_DNA.
DR   EMBL; AALDNI010000049; ECY5343333.1; -; Genomic_DNA.
DR   EMBL; AAMLUT010000056; EDI6668063.1; -; Genomic_DNA.
DR   EMBL; DAAFPQ010000022; HAB0973040.1; -; Genomic_DNA.
DR   EMBL; DAANSJ010000007; HAD1212665.1; -; Genomic_DNA.
DR   EMBL; JYVU01000038; KTZ10128.1; -; Genomic_DNA.
DR   EMBL; RSUA01000071; MIT51899.1; -; Genomic_DNA.
DR   EMBL; RVDJ01000023; MLP87429.1; -; Genomic_DNA.
DR   EMBL; PHGX01000074; PJH59926.1; -; Genomic_DNA.
DR   RefSeq; WP_001181501.1; NZ_WXYU01000001.1.
DR   KEGG; seni:CY43_03965; -.
DR   PATRIC; fig|59201.158.peg.833; -.
DR   eggNOG; COG0567; Bacteria.
DR   OMA; RDSYCRT; -.
DR   Proteomes; UP000034636; Chromosome.
DR   Proteomes; UP000054461; Unassembled WGS sequence.
DR   Proteomes; UP000228538; Unassembled WGS sequence.
DR   Proteomes; UP000338496; Unassembled WGS sequence.
DR   Proteomes; UP000839581; Unassembled WGS sequence.
DR   Proteomes; UP000839595; Unassembled WGS sequence.
DR   Proteomes; UP000839616; Unassembled WGS sequence.
DR   Proteomes; UP000839617; Unassembled WGS sequence.
DR   Proteomes; UP000839905; Unassembled WGS sequence.
DR   Proteomes; UP000839907; Unassembled WGS sequence.
DR   Proteomes; UP000839908; Unassembled WGS sequence.
DR   Proteomes; UP000839909; Unassembled WGS sequence.
DR   Proteomes; UP000839911; Unassembled WGS sequence.
DR   Proteomes; UP000839914; Unassembled WGS sequence.
DR   Proteomes; UP000839915; Unassembled WGS sequence.
DR   Proteomes; UP000885258; Unassembled WGS sequence.
DR   Proteomes; UP000885385; Unassembled WGS sequence.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:HAD1212665.1};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          591..784
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   933 AA;  104824 MW;  1FCFE6D4E4DBA5F8 CRC64;
     MQNSALKAWL DSSYLSGSNQ SWIEQLYEDF LTDPDSVDAN WRLTFQQLPG TGVKPDQLHS
     KTREYFRRQA LAGSRHSSTI SDPDTNVKQV KVLQLINAYR FRGHQHANLD PLGLWKQERV
     ADLDPSFHDL TEADFQETFN VGSFASGKET MKLGELLDAL KQTYCGPIGA EYMHITSTEE
     KRWIQQRIES GRAAFSADEK KRFLNELTAA EGLERYLGAK FPGAKRFSLE GGDALIPMLK
     EMVRHAGNSG TREVVLGMAH RGRLNVLINV LGKKPQDLFD EFAGKHKEHL GTGDVKYHMG
     FSSDIETEGG LVHLALAFNP SHLEIVSPVV MGSVRARLDR LDEPSSNKVL PITIHGDAAV
     TGQGVVQETL NMSKARGYEV GGTVRIVINN QVGFTTSNPL DARSTPYCTD IGKMVQAPIF
     HVNADDPEAV AFVTRLALDF RNTFKRDVFI DLVCYRRHGH NEADEPSATQ PLMYQKIKKH
     PTPRKIYADK LEADKVATLE DATEMVNLYR DALDAGECVV KEWRPMNMHS FTWSPYLNHE
     WDEAYPNKVE MKRLQELAKR ISTVPEAIEM QSRVAKIYGD RQAMAAGEKL FDWGGAENLA
     YATLVDEGIP VRLSGEDSGR GTFFHRHAVI HNQTNGSTYT PLQHIHSGQG QFKVWDSVLS
     EEAVLAFEYG YATAEPRTLT IWEAQFGDFA NGAQVVIDQF ISSGEQKWGR MCGLVMLLPH
     GYEGQGPEHS SARLERYLQL CAEQNMQVCV PSTPAQVYHM LRRQALRGMR RPLVVMSPKS
     LLRHPLAVST LDELANGSFQ PAIGEIDELD PKAVKRVVMC SGKVYYDLLE QRRKNDQKDV
     AIVRIEQLYP FPHKAVQEAL QPYAHVHDFV WCQEEPLNQG AWYCSQHHFR EVTPFGAALR
     YAGRPASASP AVGYMSVHQK QQQDLVNDAL NVD
//

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