ID A0A0D9R2M5_CHLSB Unreviewed; 4969 AA.
AC A0A0D9R2M5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|Ensembl:ENSCSAP00000002864.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002864.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002864.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AQIB01133841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007981735.1; XM_007983544.1.
DR RefSeq; XP_007981736.1; XM_007983545.1.
DR STRING; 60711.ENSCSAP00000002864; -.
DR Ensembl; ENSCSAT00000004619.1; ENSCSAP00000002864.1; ENSCSAG00000006581.1.
DR KEGG; csab:103227268; -.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000155281; -.
DR OMA; MYCKHLE; -.
DR OrthoDB; 4253584at2759; -.
DR BioGRID-ORCS; 103227268; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 21.
DR Bgee; ENSCSAG00000006581; Expressed in prefrontal cortex and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50216; DHHC; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 228..332
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 342..392
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 345..390
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 389..439
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 465..521
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 958..1011
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1008..1058
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1085..1140
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4457..4565
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4829..4945
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4953..4969
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1709..2423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2588..2693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2791..2875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2927..2948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2996..3026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3356..3412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3466..3490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3598..3806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3828..3885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4082..4111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1910..1962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2034..2052
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2081..2129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2138..2159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2179
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2180..2201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2204..2223
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2229..2252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2261..2275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2276..2290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2302..2318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2330..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2387..2401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2627..2647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2660..2683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2791..2808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2809..2825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2833..2847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2848..2862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3216..3234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3367..3381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3394..3412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3470..3490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3625..3708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3712..3743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3846..3881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4969 AA; 547825 MW; CD1ECC0EF1E8A0B9 CRC64;
MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK
TAVEDEDSMD GLETTETETI VETAEIKEQS AEEDAEAEAD NSKQLIPALQ RSVSEESANS
LVSVGVEAKI SEQLCAFCYC GEKSSLGQGD LKQFRVTPGF ILPWRNQPSN KKDIDDNSNG
TYEKMQNSAP RKQRGQRKER SPQQNIVSCV SVSTQTASDD QAGKLWDELS LVGLPDAIDV
QALFDSTGTC WAHHRCVEWS LGVCQMEEPL LVNVDKAVVS GSTERCAFCK HLGATIKCCE
EKCTQMYHYP CAAGAGTFQD FSHIFLLCPE HIDQAPERSK EDANCAVCDS PGDLLDQFFC
TTCGQHYHGM CLDIAVTPLK RAGWQCPECK VCQNCKQSGE DSKMLVCDTC DKGYHTFCLQ
PVMKSVPTNG WKCKNCRICI ECGTRSSSQW HHNCLICDNC YQQQDNLCPF CGKCYHPELQ
KDMLHCNMCK RWVHLECDKP TDHELDPQLK EEYICMYCKH LGAEMDPLQP GEEVEIAELT
TDYNNEMEVE GPEDQMVFPE HAVSKDVNDQ ESAPGIVPDA VQVHTEEQKK SHPSESLDTD
SLLIAVSSQH KMNTELEKQI SNEVDSEEMK TSSEVKHICG EDQMEDNMEV TENIEVVTHQ
MIVQQEELQL LEEPKTVVSK EESGPPKLVI ESVTLPLETL VSPHEGSISL CPEEQLVIER
LQGEKEQKEN SGLSTGLMDS EMTPTIESCV KDVSYQGDIS IKLSSETESS FSSSADISKA
DVSSSPTPSS DLPSHDMLHN YPSALSSSAG NIMPTTYISV TPKIGMGKPA ITKRKFSPGR
PRSKQGAWST HNTVSPPSWS PDISEGREIF KPRQLPGSAI WSIKVGRGSG FPGKRRPRGA
GLSGRGGRGR SKLKSGIGAV VLPGVSAADI SSNKDDEENS MHNTVVLFSS SDKFTLNQDM
CVVCGSFGQG AEGRLLACSQ CGQCYHPYCV SIKITKVVLS KGWRCLECTV CEACGKATDP
GRLLLCDDCD ISYHTYCLDP PLQTVPKGGW KCKWCVWCRH CGATSAGLRC EWQNNYTQCA
PCASLSSCPV CYRNYREEDL ILQCRQCDRW MHAVCQNLNT EEEVENVADI GFDCSMCRPY
MPASNVPSSD CCESSLVAQI VTKVKELDPP KTYTQDGVCL TESGMTQLQS LTVTVPRRKR
SKPKLKLKII NQNSVAVLQT PPDIQSEHSR DGEMDDSREG ELMDCDGKSE SSPEREAVDD
ETKGVEGTDG VKKRKRKPYR PGIGGFMVRQ RSRTGQGKTK RSVIRKDSSG SISEQLPCRD
DGWSEQLPDT LVDESVSVTE STEKIKKRYR KRKNKLEETF PAYLQEAFFG KDLLDTSRQS
KISLDNLSED AAQLSYKTNM NAGFLDPSLD PLLSSSSAPT KSGTHGPADD PLADISEVLN
TDDDILGIIS DDLAKSVDHS DIGPVPDDPS LPQPSVNQSS RPLSEEQLDG ILSPELDKMV
TDGAILGKLY KIPELGGKDV EDLFTAVLSP ANTQPTPLPQ PPPPTQLLPI HNQDVFSRMP
LMNGLIGPSP HLPHNSLPPG SGLGTFSAIA QSPYPDVRDK NSAFNPMASD PNNSWTSSAP
TVEGENDTLS NAQRSTLKWE KEEALGEMAT VAPVLYTNIN FPNLKEEFPD WTTRVKQIAK
LWRKASSQER APYVQKARDN RAALRINKVQ MSNDSMKRQQ QQDSIDPSSR IDSELFKDPL
KQRESEHEQE WKFRQQMRQK SKQQAKIEAT QKLEQVKNEQ QQQQQQQFGS QHLLVQSGSD
TPSSGIQSPL TPQPGNGNMS PAQSFHKELF TKQPPSTPTS TSDDVFVKPQ APPPPPAPSR
IPIQEGLSQA QTSQPPSPQV FSPGSSNSRP PSPMDPYAKM VGTPRPSPVG HSFSRRNSAA
PVENCTPLSS VSRPLQMNET TANRPSPVRD LCSSSMTNND PYAKPPDTPR PVMTDQFPKS
LGLSRSPIVS EQTAKGPVAA GTNDHFTKPS PRVDVFQRQR IPDPYARPLL TPAPLDSGPG
PFKTPMQPPP SSQDPYGSVS QASRRLSIDP YERPALTPRP IDNFSHNQSN DPYSQPPLTP
HPTMNESFAH PSRAFSQPGT ISRPTSQDPY SQPPGTPRPV VDSYSQSSGT ARSNTDPYSQ
PPGTPRPTTV DPYSQQPPTP RPSTQTDLFV TSVTNQRHSD PYAHPPGTPR PGISVPYSQP
PATPRPRISE GFTRSSMTRP VLMPNQDPFL QAAQNRGPAL PGPLVRPPDT CSQTPRPPGP
GLSDTFSRVS PSAARDPYDQ PPVTPRSQSD SFGTSQAAHD VADQPRPGSE GSFCASSNSP
MHSQGQQFSG VSQLPGPVPT SGVTDTQNTV NMAQADTEKL RQRQKLREII LQQQQQKKIA
GRQEKGSQDS PAVPHPGPLQ HWQPENINQA FARPPPPYPG NIRSPVAPPL GPRYAVFPKD
QRGPYPPDVA SMGMRPHGFR FGFPGGSHGT MPSQERFLVP PQQIQGSGVS PQLRRSISVD
MPRPLNNSQM NNPVGLPQHF SPQSLPVQQH NILGQAYIEL RHRAPDGRQR LPFSAPPGSV
VEASSNLRHG NFIPRPDFPG PRHTEPMRRP PHGLPNQLPV HPDLEQVPPS QQEQGHSVHS
SSVVMRTLNH PLGGEFSEAP LSTSVPSETT SDNLQITTQP SDGLEEKLDS DDPSVKELDV
KDLEGVEVKD LDDEDLENLN LDTEDGKVVE LDTLDNLETN DPNLDDLLRS GEFDIIAYTD
PELDLGDKKS MFNEELDLPM DDKLDNQCAS VEPKKKEQED KTLVLSDKHS PQKKSTVTNE
VKMEVLSPNS KVESKCETEK SDENKDNVDP PCSQASAHSD LNDGEKTSLH PCDPDLCEKR
TNRETADSSA NVIQGSTQLP AQDVINSCGI TGSTPVLSSL LANEKSDNSD IRPLGSPPPT
LPASPSNHVS SLPPLIAPPG HVLDNTVNSN VTVVSRVNHV FSQGVQVNSG FIPGQSTVNH
NLGTGKPTTQ TGPLTSQSGT SSVSGPQQLM IPQTLAQQNR ERPLLLEEQP LLLQDLLDQE
RQEQQQQRQM QAMIRQRSEP FFPNIDFDAI TDPIMKAKMV ALKGINKVMA QNNLGMPPMV
MSRFPFMGQA VTGTQNSEGQ NLGPQAIPQD GSITHQISRP NPPNFGPGFV NDSQRKQYEE
WLQETQQLLQ MQQKYLEEQI GAHRKSKKAL SAKQRTAKKA GREFPEEDAE QLKHVTEQQS
MVQKQLEQIR KQQKEHAELI EDYRIKQQQQ QQQCAMAPPT MMPSVQPQPP LIPGATPPTM
SQPSFPMVPQ QLQHQHQQHT TVISGHTSPV RMPNLPGWQP NSAPAHLPLN PPRIQPPIAQ
LPIKTCTPAP GTVSNANPQS GPPPRVEFDD NNPFSESFQE RERKERLREQ QERQRIQLMQ
EVDRQRALQQ RMEMEQHGMV GSEISSSRTS VSQIPFYSSD LPCDFMQPPR PLQQSPQHQQ
QMGQVLQQQN IQQGSINSPS TQTFMQTNER RQVGPPSFVP DSPSIPVGSP NFSSVKQGHG
NLSGTSFQPS PVRPSFTPAL PAAPPVANSS LPCGQDSTIT HGHSYPASTQ SLIQLYSDII
PEEKGKKKRT RKKKRDDDAE STKAPSTPHS DITAPPTPSI SETTSTPAVS TPSELPQQAD
QESVEPVGPS TPSMAAGQLC TEVENKLPNS DFSQATPNQQ TYANSEVDKL SMETPAKTEE
IKLEKPETES CPGQEEPKLE EQSGSKVEGN AVACPVSSAQ SPPHSVGAPA AKGDSGNELL
KHLLKNKKSS SLLNQKPEGN ICSEDDCTKE NKLVEKQNPA EGLQTLGAQM QGGFGCGNQL
PKTDGGSETK KQRSKRTQRT GEKAAPRSKK RKKDEEEKQA MYSSTDTFTH LKQQLSLLPL
MEPIIGVNFA HFLPYGSGQF NSGNRLLGTF GSATLEGVSD YYSQLIYKQN NLSNPPTPPA
SLPPTPPPMA CQKMANGFAT TEELAGKAGV LVSHEVTKTL GPKPFQLPFR PQDDLLARAL
AQGPKTVDVP ASLPTPPHNN QEELRIQDHC GDRDTPDSFV PSSSPESVVG VEVSRYPDLS
LVKEEPPEPV PSPIIPILPS TAGKSSESRR NDIKTEPGTL YFASPFGSSP NGPRSGLISV
AITLHPTAAE NISSVVAAFS DLLHVRIPNS YEVSNAPDVP SMGLVSSHRI NPGLEYRQHL
LLRGPPPGSA NPPRLVSSYR LKQPNVPFPP TSNGLSGYKD SSHGIAESTA LRPQWCCHCK
VVILGSGVRK SFKDLTLLNK DSRESTKRVE KDIVFCSNNC FILYSSTAQA KNSENKESIP
SLPQSPMRET PSKAFHQYSN NISTLDVHCL PQLQEKASPP ASPPIAFPPA FEAAKVEAKP
DELKVTVKLK PRLRTVHGAF EDCRPLNKKW RGMKWKKWSI HIVIPKGTFK PPCEDEIDEF
LKKLGTSLKP DPVPKDYRKC CFCHEEGDGL TDGPARLLNL DLDLWVHLNC ALWSTEVYET
QAGALINVEL ALRRGLQMKC VFCHKTGATS GCHRFRCTNI YHFTCAIKAQ CMFFKDKTML
CPMHKPKGIH EQELSYFAVF RRVYVQRDEV RQIASIVQRG ERDHTFRVGS LIFHTIGQLL
PQQMQAFHSP KALFPVGYEA SRLYWSTRYA NRRCRYLCSI EEKDGRPVFV IRIVEQGHED
LVLSDISPKG VWDKILEPVA CVRKKSEMLQ LFPAYLKGED LFGLTVSAVA RIAESLPGVE
ACENYTFRYG RNPLMELPLA VNPTGCARSE PKMSAHVKRF VLRPHTLNST STSKSFQSTV
TGELNAPYSK QFVHSKSSQY RKMKTEWKSN VYLARSRIQG LGLYAARDIE KHTMVIEYIG
TIIRNEVANR KEKLYESQNR GVYMFRMDND HVIDATLTGG PARYINHSCA PNCVAEVVTF
ERGHKIIISS NRRIQKGEEL CYDYKFDFED DQHKIPCHCG AVNCRKWMN
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