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Database: UniProt/TrEMBL
Entry: A0A0D9S570_CHLSB
LinkDB: A0A0D9S570_CHLSB
Original site: A0A0D9S570_CHLSB 
ID   A0A0D9S570_CHLSB        Unreviewed;      2964 AA.
AC   A0A0D9S570;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00591749};
DE            EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00591749};
GN   Name=ASH1L {ECO:0000313|Ensembl:ENSCSAP00000016009};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016009, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000016009, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000016009}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000016009}.
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DR   EMBL; AQIB01138883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01138892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007975030.1; XM_007976839.1.
DR   RefSeq; XP_007975031.1; XM_007976840.1.
DR   Ensembl; ENSCSAT00000000042; ENSCSAP00000016009; ENSCSAG00000002027.
DR   GeneID; 103223879; -.
DR   KEGG; csab:103223879; -.
DR   CTD; 55870; -.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K06101; -.
DR   OMA; HSEMTDY; -.
DR   Proteomes; UP000029965; Chromosome 20.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:Ensembl.
DR   GO; GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR   GO; GO:0097676; P:histone H3-K36 dimethylation; IEA:Ensembl.
DR   GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0002674; P:negative regulation of acute inflammatory response; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   GO; GO:0097722; P:sperm motility; IEA:Ensembl.
DR   GO; GO:1903699; P:tarsal gland development; IEA:Ensembl.
DR   GO; GO:1903709; P:uterine gland development; IEA:Ensembl.
DR   GO; GO:0061038; P:uterus morphogenesis; IEA:Ensembl.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00384; AT_hook; 4.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00591173};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533};
KW   Zinc {ECO:0000256|SAAS:SAAS00592951};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00592111}.
FT   DOMAIN     2086   2137       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     2140   2256       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     2264   2280       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2458   2528       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   DOMAIN     2656   2793       BAH. {ECO:0000259|PROSITE:PS51038}.
SQ   SEQUENCE   2964 AA;  332308 MW;  B22C0F02838211F7 CRC64;
     MDPRNTAMLG LGSDSEGFTR KSPSAISTGT LVSKREVELE KNTKEEEDLR KRNRERNIEA
     GKDDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP KNLENYVCRP AIKTTIKHPR
     KALKSGKMTD EKNEHCPSKR DPSKLYKKAD DVAAIECQSE EVIHLHSQGE NNPLSKKLSP
     VHSEMADYIN ATPSTLVGSR DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL
     GTGTTAGLVS KDLIRKAGVG SVAGIIHKDL IKKPTISTAV GLVTKDPGKK PVFNAALGLV
     NKDSVKKLGT GTTAVFINKD LGKKPGTITT VGLLSKDSGK KLGIGIVPGL VNKESGKKLG
     LGTVVGLVNK DLGKKLGSTV GLVAKDCAKK IVASSAMGLV NKDIGKKLVS CPLAGLISKD
     AINLKAEALL PTQEPLKASC STNINNQDSQ ELSESLKDSA TSKTFEKNVI RQTKESILEK
     FSVRKETINL EKEMFNEGTS IQQDSFSSNE RGSYETSKHE KQPPVYCTSP DFQMGGASDV
     STAKSPFSAV GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSSTTE LIEEISESLG
     KNQFTSESTH LNVGHRSVGH SISIECKGID KEVNDSKTTH IDIPRISSSL GKKPSLTSES
     SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL STSLQSKPLK KRKGRKPRWT
     KVVARSTCRS PKGLELERSE LFKNVSCSSL SNSNSEPAKF MKNIAPPSFV DHDFLKRRLP
     KLSKSTAPSL ALLADSEKPS HKSFATHKLS SSMCVSSDLL SDIYKPKRGR PKSKEMPQLE
     GPPKRTLKIP ASKVFSLQSK EEQEPPILQP EIEIPSFKQS LSVSPFPKKR GRPKRQMRSP
     VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD SHRPSVCSMS
     DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ ILSSSVESSN KGKVQSKLHN
     TVSSLAATFG SKLGQQINVS KKGTIYIGKR RGRKPKTVLN GILSGSPTSL AVLEQTAQQA
     TGSALGQILP PLLPSSASSS EILPSPICSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS
     RQGSMIQTLA MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD
     SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH KCKRRNHDYL
     SYDKMKRQKR KRKKKYPQLR NRQDPDFIAE LEELISRLSE IRITHRSHHF IPRDLLPTIF
     RINFNSFYTH PSFPLDPLHY IRKPDLKKKR GRPPKMREAM AEMPFMHSLS FPLSSTGFYP
     SYGMPYSPSP LTAAPIGLGY YGRYPPTLYP PPPSPSFTTP LPPPSYMHAG HLLLNPAKYH
     KKKHKLLRQE AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV
     SMDTGASRSV LESLKRYRFG KDTVGERYKH KEKHRCHMSC PHLSPSKSLI NREEQWVHRE
     PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSEPASS DEHTNLFTSA IGSCRVSNPN
     SSGRKKLTDS PGLFSAQDTS LNRSHRKESL PSNERAVQTS AGSQPTSDKP SQRPSESTNC
     SPTRKRSSSE STSSTVNGVP SRSPRLVASG DDSVDSLLQR MVQNEDQEPM EKRIDAVIAT
     ASAPPSSSPG RSHSKDRTLG KPDSLLVPAV ASDSCNNSIS LLSEKLTSSC SPHHIKRSVV
     EAMQRQARKM CNYNKILATK KNLDHVNKIL KAKKLQRQAR TGNNFVKRRP GRPRKCPLQA
     VVSMQAFQAA QFVNPELNRG EEGAALHLSP DTVTDVIEAV VQSVNLNPEH KKGLKRKGWL
     LEEQTRKKQK PLPEEEEQEN NKSFNEAPVE IPSPPETPAK PPEPESTLQP VLSLIPREKK
     PPRPPKKKYQ KAGLYSDVYK TTDPKSRLIQ LKKEKLEYTP GEHEYGLFPA PIHVGKYLRQ
     KRIDFQLPYD ILWQWKHNQL YKKPDVPLYK KIRSNVYVDV KPLSGYEATT CNCKKPDDDT
     RKGCVDDCLN RMIFAECSPN TCPCGEQCCN QRIQRHEWVQ CLERFRAEEK GWGIRTKEPL
     KAGQFIIEYL GEVVSEQEFR NRMIEQYHNH SDHYCLNLDS GMVIDSYRMG NEARFINHSC
     DPNCEMQKWS VNGVYRIGLY ALKDMPAGTE LTYDYNFHSF NVEKQQLCKC GFEKCRGIIG
     GKSQRVNGLS SSKNSQPMAT HKKSGRSKEK RKSKHKLKKR RGHLSEEPNE NINTPTRLTP
     QLQMKPMSNR ERNFVLKHHV FLVRNWEKIH QKQEEVKHTS DNIHSASLYT RWNGICRDDG
     NIKSDVFMTQ FSALQTARSV RTRRLAAAEE NIEVARAARL AQIFKEICDG IISYKDSSRQ
     ALAAPLLNLP PKKKNADYYE KISDPLDLIT IEKQILIGYY KTVEAFDADM LKVFRNAEKY
     YGRKSPIGRD VCRLRKAYYN ARHEASAQID EIVGETASEA DSSETSVSEK ENGHEKDDDV
     IRCICGLYKD EGLMIQCDKC MVWQHCDCMG VNSDVEHYLC EQCDPRPVDR EVPMIPRPHY
     AQPGCVYFIC LLRDDLLLRQ GDCVYLMRDS RRTPDGHPVR QSYRLLSHIN RDKLDIFRIE
     KLWKNEKEER FAFGHHYFRP HETHHSPSRR FYHNELFRVP LYEIIPLEAV VGTCCVLDLY
     TYCKGRPKGV KEQDVYICDY RLDKSAHLFY KIHRNRYPVC TKPYAFDHFP KKLTPKKDFS
     PHYVPDNYKR NGGRSSWKSE RSKPPLKDLG QEDDALPLIE EVLARQEQTA SEIPSLEEPE
     REGATANVSE GEKKTEESSQ EPQSTCTPEE RRHNQRERLN QILLNLLEKI PGKNAIDVTY
     LLEEGSGRKL RRRTLFIPEN SFRK
//
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