ID A0A0E0UZH4_LISMM Unreviewed; 353 AA.
AC A0A0E0UZH4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|PIRNR:PIRNR005096};
GN Name=galM {ECO:0000313|EMBL:AEH93523.1};
GN OrderedLocusNames=LMM7_2518 {ECO:0000313|EMBL:AEH93523.1};
OS Listeria monocytogenes serotype 4a (strain M7).
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1030009 {ECO:0000313|EMBL:AEH93523.1, ECO:0000313|Proteomes:UP000000486};
RN [1] {ECO:0000313|EMBL:AEH93523.1, ECO:0000313|Proteomes:UP000000486}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M7 {ECO:0000313|EMBL:AEH93523.1,
RC ECO:0000313|Proteomes:UP000000486};
RX PubMed=21742872; DOI=10.1128/JB.05501-11;
RA Chen J., Xia Y., Cheng C., Fang C., Shan Y., Jin G., Fang W.;
RT "Genome sequence of the nonpathogenic Listeria monocytogenes serovar 4a
RT strain M7.";
RL J. Bacteriol. 193:5019-5020(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP002816; AEH93523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E0UZH4; -.
DR KEGG; lmq:LMM7_2518; -.
DR PATRIC; fig|1030009.3.peg.2508; -.
DR HOGENOM; CLU_031753_1_1_9; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000000486; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096}.
FT ACT_SITE 182
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 317
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 182..184
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 255
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 353 AA; 39690 MW; 63943DE34CCE25CE CRC64;
MVFIEVIQEQ FGEFEGKTVW QWTMVNDHGM RMSVLNYGAI VTSLETKDKF GNLANISLGF
TNLDDYLAHS PYFGATLGPV AGRISNGQFK LDGKQFQLTQ NEGTNHRHGG KLNFSKKIWN
VTVEKELDQI VMTFDYCWAD GENGYPGNIN ARMTYTLNNK NEWLIDYEAK SDKPTIYNPS
NHIYFNLSGE TGSTVLQHQL WINSDRFLPI DGESIPIGEK RSVENTIFDL RAGRELAEIT
QSQDQQIKLV GAGLDHAFIL KHENGRPDAV LFDPQSGRRL EMETESDSVL VYTANSLDST
FEIDGRAGPK YAGITMETQG LVDAINQDGF GDIVLRPEKP FTSRTAFRFT AES
//
