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Database: UniProt/TrEMBL
Entry: A0A0E1EGL7_STRAG
LinkDB: A0A0E1EGL7_STRAG
Original site: A0A0E1EGL7_STRAG 
ID   A0A0E1EGL7_STRAG        Unreviewed;       931 AA.
AC   A0A0E1EGL7;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-SEP-2017, entry version 23.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595};
GN   ORFNames=AX245_05180 {ECO:0000313|EMBL:OCM71213.1}, EN72_04540
GN   {ECO:0000313|EMBL:AIF86348.1}, WA34_17190
GN   {ECO:0000313|EMBL:KLL20575.1};
OS   Streptococcus agalactiae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1311 {ECO:0000313|EMBL:AIF86348.1, ECO:0000313|Proteomes:UP000028184};
RN   [1] {ECO:0000313|EMBL:AIF86348.1, ECO:0000313|Proteomes:UP000028184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NGBS061 {ECO:0000313|EMBL:AIF86348.1,
RC   ECO:0000313|Proteomes:UP000028184};
RA   Teatero S., McGeer A., Li A., Gomes J., Seah C., Demczuk W.,
RA   Martin I., Wasserscheid J., Dewar K., Melano R.G., Fittipaldi N.;
RT   "Population Structure and Antimicrobial Susceptibility of Emerging
RT   Invasive Serotype IV Group B Streptococcus in Toronto, Canada.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KLL20575.1, ECO:0000313|Proteomes:UP000035620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK-PW-092 {ECO:0000313|EMBL:KLL20575.1,
RC   ECO:0000313|Proteomes:UP000035620};
RX   PubMed=25946017;
RG   DEVANI Consortium;
RA   Rosini R., Campisi E., De Chiara M., Tettelin H., Rinaudo D.,
RA   Toniolo C., Metruccio M., Guidotti S., Sorensen U.B., Kilian M.,
RA   Ramirez M., Janulczyk R., Donati C., Grandi G., Margarit I.;
RT   "Genomic analysis reveals the molecular basis for capsule loss in the
RT   group B streptococcus population.";
RL   PLoS ONE 10:E0125985-E0125985(2015).
RN   [3] {ECO:0000313|EMBL:OCM71213.1, ECO:0000313|Proteomes:UP000093122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CZ-PW-140 {ECO:0000313|EMBL:OCM71213.1,
RC   ECO:0000313|Proteomes:UP000093122};
RX   PubMed=27411639; DOI=10.1038/srep29799;
RA   Campisi E., Rinaudo C.D., Donati C., Barucco M., Torricelli G.,
RA   Edwards M.S., Baker C.J., Margarit I., Rosini R.;
RT   "Serotype IV Streptococcus agalactiae ST-452 has arisen from large
RT   genomic recombination events between CC23 and the hypervirulent CC17
RT   lineages.";
RL   Sci. Rep. 6:29799-29799(2016).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000256|HAMAP-
CC       Rule:MF_00595, ECO:0000256|SAAS:SAAS00730191}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|HAMAP-Rule:MF_00595,
CC       ECO:0000256|SAAS:SAAS00635165}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00595, ECO:0000256|SAAS:SAAS00635164};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635168}.
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DR   EMBL; CP007631; AIF86348.1; -; Genomic_DNA.
DR   EMBL; LBKE01000074; KLL20575.1; -; Genomic_DNA.
DR   EMBL; MAWT01000033; OCM71213.1; -; Genomic_DNA.
DR   RefSeq; WP_000019267.1; NZ_NAPX01000001.1.
DR   STRING; 211110.gbs0780; -.
DR   EnsemblBacteria; AIF86348; AIF86348; EN72_04540.
DR   EnsemblBacteria; CND75036; CND75036; ERS039640_00572.
DR   EnsemblBacteria; KLL20575; KLL20575; WA34_17190.
DR   EnsemblBacteria; OCM71213; OCM71213; AX245_05180.
DR   KEGG; sage:EN72_04540; -.
DR   PATRIC; fig|1311.133.peg.832; -.
DR   KO; K01595; -.
DR   Proteomes; UP000028184; Chromosome.
DR   Proteomes; UP000035620; Unassembled WGS sequence.
DR   Proteomes; UP000093122; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 2.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635173};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028184,
KW   ECO:0000313|Proteomes:UP000035620, ECO:0000313|Proteomes:UP000093122};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635169};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635157};
KW   Pyruvate {ECO:0000313|EMBL:AIF86348.1}.
FT   ACT_SITE    138    138       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    594    594       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   931 AA;  105962 MW;  F5338365FADF9B2C CRC64;
     MSHPKLESSS NKEIITEEVG LLKQLLDEAT QKLIGSESFD KIEKIVSLSL TDDYTGLKET
     ISALSNEEMV IVSRYFSILP LLINISEDVD LAYEINYKNN LNQDYLGKLS TTIDVVAGHE
     NAKDILEHVN VVPVLTAHPT QVQRKTVLEL TSKIHDLLRK YRDVKAGIVN QEKWYADLRR
     YIGIIMQTDT IREKKLKVKN EITNVMEYYN RSLIKAVTKL TAEYKALAAK KGIHLENPKP
     LTMGMWIGGD RDGNPFVTAE TLRLSAMVQS EVIINHYIEQ LNELYRNMSL SINLTEVSPE
     LVTLANQSQD NSVYRENEPY RKAFNFIQDK LVQTLLNLKV GSSPKEKFVS RQESSDIVGR
     YIKSHIAQVA SDIQTEELPA YATAEEFKQD LLLVKQSLVQ YGQDSLVDGE LACLIQAVDI
     FGFYLATIDM RQDSSINEAC VAELLKSANI VDDYSSLSEE EKCQLLLKEL TEDPRTLSST
     HAPKSELLQK ELAIFQTARE LKDQLGEDII NQHIISHTES VSDMFELAIM LKEVGLIDAN
     QARIQIVPLF ETIEDLDNSR DIMTQYLHYE LVKKWIATNN NYQEIMLGYS DSNKDGGYLS
     SGWTLYKAQN ELTKIGEENG IKITFFHGRG GTVGRGGGPS YEAITSQPFG SIKDRIRLTE
     QGEIIENKYG NQDAAYYNLE MLISASIDRM VTRMITNPNE IDNFRETMDG IVSESNAVYR
     NLVFDNPYFY DYFFEASPIK EVSSLNIGSR PAARKTITEI SGLRAIPWVF SWSQNRIMFP
     GWYGVGSAFK HFIEQDEANL AKLQTMYQKW PFFNSLLSNV DMVLSKSNMN IALQYAQLAG
     SKEVRDVFNI ILNEWQLTKD MILAIEQHDN LLEENPMLHA SLDYRLPYFN VLNYVQIELI
     KRLRSNQLDE DYEKLIHITI NGIATGLRNS G
//
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