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Database: UniProt/TrEMBL
Entry: A0A0E3N1A2_CORUL
LinkDB: A0A0E3N1A2_CORUL
Original site: A0A0E3N1A2_CORUL 
ID   A0A0E3N1A2_CORUL        Unreviewed;       748 AA.
AC   A0A0E3N1A2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   05-JUL-2017, entry version 10.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AKA96058.1};
GN   Name=icd {ECO:0000313|EMBL:AKA96058.1};
GN   ORFNames=CUL131002_0510c {ECO:0000313|EMBL:AKA96058.1};
OS   Corynebacterium ulcerans.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=65058 {ECO:0000313|EMBL:AKA96058.1, ECO:0000313|Proteomes:UP000033037};
RN   [1] {ECO:0000313|EMBL:AKA96058.1, ECO:0000313|Proteomes:UP000033037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=131002 {ECO:0000313|EMBL:AKA96058.1,
RC   ECO:0000313|Proteomes:UP000033037};
RA   Benevides L.J., Viana M.V.C., Mariano D.C., Rocha F.S., Bagano P.,
RA   Folador E.L., Pereira F.L., Dorella F.A., Leal C.A., Carvalho A.F.,
RA   Soares S.C., Carneiro A.R., Ramos R.T.J., Silva A., Figueiredo H.C.,
RA   Azevedo V., Guimaraes L.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP011095; AKA96058.1; -; Genomic_DNA.
DR   STRING; 945712.CULC22_00510; -.
DR   EnsemblBacteria; AKA96058; AKA96058; CUL131002_0510c.
DR   KEGG; cuj:CUL131002_0510c; -.
DR   PATRIC; fig|65058.63.peg.506; -.
DR   KO; K00031; -.
DR   Proteomes; UP000033037; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000033037};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      142    149       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       357    357       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       559    559       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     155    155       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     554    554       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        264    264       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        427    427       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   748 AA;  81207 MW;  A9110548583FA081 CRC64;
     MFVQRARLKR RLMAKIIYTR TDEAPLLATY SLKPVVEAFA STAGIEVETR DISLAGRILS
     QFPEFLTEDQ KVDDALAELG DLAKTPEANI IKLPNISASV PQLKAAVAEL QSQGYKLPDY
     PDSPSTDEEK DIRARYDAVK GSAVNPVLRE GNSDRRAPIA VKNFAKKHPH RMGAWSADSK
     TNVVTMESND FRHNEKSVIM PSDDTLTIKL VTDNGEKVLK EGLKVLKGEV IDGTFISARA
     LDEFLAVQVK RAKDEGVLFS AHLKATMMKV SDPIIFGHVV RAYFADVFAT YGEQLEAAGL
     NGENGLAAIY SGLESLPNGA EIKAAFDAAL ESGADIAMVN SAKGITNLHV PSDVIIDASM
     PAMIRTSGHM WNKNDEEQDT LAVIPDSSYA GVYQTVIADC KKNGAFDPTT MGTVPNVGLM
     AQKAEEYGSH DKTFKIEANG TVQVVNSAGE VLIEHNVEAG DIWRACQAKD APIQDWVKLA
     VTRSRLSGMP AVFWLDPERA HDRNLTTLVE KYLADHDTEG LDIRIMSPVD ATQFSIDRIR
     RGEDTISVTG NVLRDYNTDL FPILELGTSA KMLSVVPLMA GGGLFETGAG GSAPKHVQQL
     VEENHLRWDS LGEFLALAES LRHFANTEGN TKAGVLADAL DRATETLLNE GYSPSRKAGE
     IDNRGSHFFL TKFWAKELSI QSEDADLAAT FAPVAEALEA HSDEIADALL AVQGAPADLG
     GYYQPDDAKT TAIMRPVASY NNIISSIK
//
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