ID A0A0E3QUZ7_METBA Unreviewed; 587 AA.
AC A0A0E3QUZ7;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN ORFNames=MSBRM_1439 {ECO:0000313|EMBL:AKB54437.1};
OS Methanosarcina barkeri MS.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434108 {ECO:0000313|EMBL:AKB54437.1, ECO:0000313|Proteomes:UP000033033};
RN [1] {ECO:0000313|EMBL:AKB54437.1, ECO:0000313|Proteomes:UP000033033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS {ECO:0000313|EMBL:AKB54437.1,
RC ECO:0000313|Proteomes:UP000033033};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001714};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the AOR/FOR family.
CC {ECO:0000256|ARBA:ARBA00011032}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009528; AKB54437.1; -; Genomic_DNA.
DR RefSeq; WP_048155258.1; NZ_CP009528.1.
DR AlphaFoldDB; A0A0E3QUZ7; -.
DR STRING; 1434108.MSBRM_1439; -.
DR GeneID; 24884648; -.
DR KEGG; mby:MSBRM_1439; -.
DR PATRIC; fig|1434108.4.peg.1796; -.
DR HOGENOM; CLU_020364_1_0_2; -.
DR Proteomes; UP000033033; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR PANTHER; PTHR30038:SF8; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR Pfam; PF01314; AFOR_C; 1.
DR Pfam; PF02730; AFOR_N; 1.
DR SMART; SM00790; AFOR_N; 1.
DR SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AKB54437.1}.
FT DOMAIN 13..213
FT /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00790"
SQ SEQUENCE 587 AA; 65116 MW; 8ABB63E23283ACA8 CRC64;
MTTEQYAIEG LKNILYIDLN SHSYHVKERR DLYEKYLGGV GVATNLMLEE SREGTGPLDP
EMPIILSTGP LSGVYPTCTK TVALFRSPLN GELGESYAGG HLAMSMRYSG YETIVINGAS
RYPVYVAIHD DKVTFRDASS IWHLSSAIDV GKILREIEPG AGRRSIIRIG PAGERGITYA
DVNVDTYRHF GRLGLGTVFG AKKLKAMLIS GNRELKSPEH NAYRKTVSML YDTIVKTGLT
EKYHNLGTSE NILVLNELKG LPTRNLQAAS FEGAETISGE LFAEKYLLRR VSCAGCPIGC
IHVAMLKRAF SKAHEYEALN ISYDFELIYA LGSNLGVADP EAVLELIDAC EKAGVDIISM
GVVLAWATEM QQRGKISAND SLGLKLSWGD KAAYLRAIDL VVQAPNEFYS DLGKGVEYAS
KKYGGEDFAI RLGGLEIPGY HTGLGNVLGL TVGARHSHLD SAGYSADQKA FNQPISDEQI
VDYIIDEEDR RNVLNCMVSC LFARNVYTYE NVIQALKALG IERTDEELKS LGKDIFRKKY
ALKKNFGFRF EDLRIPKRFF ETPSTTGILE EERVKRSIEL YRKKRGL
//
