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Database: UniProt/TrEMBL
Entry: A0A0E3ZIW8_9BURK
LinkDB: A0A0E3ZIW8_9BURK
Original site: A0A0E3ZIW8_9BURK 
ID   A0A0E3ZIW8_9BURK        Unreviewed;       745 AA.
AC   A0A0E3ZIW8;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   30-AUG-2017, entry version 12.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent, monomeric type {ECO:0000313|EMBL:AKD24710.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AKD24710.1};
GN   ORFNames=CL55_00003770 {ECO:0000313|EMBL:AKD24710.1};
OS   Polynucleobacter duraquae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=1835254 {ECO:0000313|EMBL:AKD24710.1, ECO:0000313|Proteomes:UP000061135};
RN   [1] {ECO:0000313|EMBL:AKD24710.1, ECO:0000313|Proteomes:UP000061135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWH-MoK4 {ECO:0000313|EMBL:AKD24710.1,
RC   ECO:0000313|Proteomes:UP000061135};
RA   Hahn M.W.;
RT   "Genome of Polynucleobacter strain MWH-MoK4.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP007501; AKD24710.1; -; Genomic_DNA.
DR   RefSeq; WP_046329629.1; NZ_CP007501.1.
DR   EnsemblBacteria; AKD24710; AKD24710; CL55_00003770.
DR   KEGG; pdq:CL55_00003770; -.
DR   PATRIC; fig|576611.7.peg.378; -.
DR   KO; K00031; -.
DR   Proteomes; UP000061135; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000061135};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AKD24710.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000061135}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       554    554       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     549    549       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   745 AA;  82345 MW;  382FA2C9D2D8D237 CRC64;
     MASETSKIIY TLTDEAPLLA TCAFLPIIRT FTAPAGVQVI ESDISVAARI LSEFSDCLTA
     EQKVPDNLGE LGRMTLLPDT NIIKLPNISA SVPQLLAAIK ELQAKGYKLP DFPDDPKNDA
     EKAIRTRYSK CLGSAVNPVL REGNSDRRAP NAVKRYARKN PHSMGEWSQA SRTHVSHMHG
     GDFYAGEKSM TMTKACDVKM DLVTKSGKTI VLKPKVSLLA GEIIDSMYMS KKALCEFYEK
     EIEDAYKTGM MLSLHVKATM MKVSHPIVFG HAVKIFYKDA FKKHGKLFEE LGVNPNNGMS
     SLYEKIKTLP ESKREEIIQD LHACHEHRPA LAMVDSAKGI TNLHSPSDVI VDASMPAMIR
     VGGKMWGADG RLHDTKAVIP ESTFARIYQE IINFCKTHGN FDPKTMGTVP NVGLMAQQAE
     EYGSHDKTFE ITETGVARIV ADDGTVLLEQ NVEEGDIWRM CQVKDAPIRD WVKLAVNRAR
     LSHTPAVFWL DEYRPHEAEL IKKVQAYLKE HDLTGVDIQI MSQTRAMRYT LERIIRGKDT
     ISVTGNILRD YLTDLFPIME LGTSAKMLSI VPLMAGGGLF ETGAGGSAPK HVQQLVEENH
     LRWDSLGEFL ALAVSLEDIG DKTNNSKVKI LARTLDEATG TLLDNNKSPS PRTGELDNRG
     SQFYLAMYWA QALAAQTEDK ELQAHFAPLA KALTENEQKI VAEFKAVQGK PADIGGYYMP
     DHDKFVAVMC PSTTLNGILK MASAA
//
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