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Database: UniProt/TrEMBL
Entry: A0A0G2K2W6_RAT
LinkDB: A0A0G2K2W6_RAT
Original site: A0A0G2K2W6_RAT 
ID   A0A0G2K2W6_RAT          Unreviewed;      2918 AA.
AC   A0A0G2K2W6;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00591749};
DE            EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00591749};
GN   Name=Ash1l {ECO:0000313|Ensembl:ENSRNOP00000072404,
GN   ECO:0000313|RGD:1306350};
GN   Synonyms=Ash1l_predicted {ECO:0000313|EMBL:EDM00676.1};
GN   ORFNames=rCG_62830 {ECO:0000313|EMBL:EDM00676.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000072404, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000072404, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072404,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDM00676.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM00676.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDM00676.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM00676.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000072404}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072404};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
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DR   EMBL; AC097039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC097294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473976; EDM00676.1; -; Genomic_DNA.
DR   RefSeq; NP_001101159.1; NM_001107689.1.
DR   UniGene; Rn.86973; -.
DR   STRING; 10116.ENSRNOP00000027629; -.
DR   Ensembl; ENSRNOT00000085690; ENSRNOP00000072404; ENSRNOG00000020386.
DR   GeneID; 310638; -.
DR   KEGG; rno:310638; -.
DR   CTD; 55870; -.
DR   RGD; 1306350; Ash1l.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K06101; -.
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000020386; -.
DR   ExpressionAtlas; A0A0G2K2W6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00384; AT_hook; 4.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00591173};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533};
KW   Zinc {ECO:0000256|SAAS:SAAS00592951};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00592111}.
FT   DOMAIN     2041   2092       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     2095   2211       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     2219   2235       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2412   2482       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   DOMAIN     2610   2747       BAH. {ECO:0000259|PROSITE:PS51038}.
SQ   SEQUENCE   2918 AA;  326473 MW;  3FD69D5732771823 CRC64;
     MDPRNTAMLG LGSDSEGFSR KSPSAISSGT LASKREVEIE GNTDEEDPRK RNRERAIEAG
     KDDGLTDAQQ QFSVKETNFS EGNLKLKIGL QAKRTKKPPK NLENYVCRPA IKTTVKHSRK
     ALKSGKMTDE KNEHCPSKWD SSKLFKKAGD ATAIECQSEE SVHLHSQGEN NPLSKKLSPV
     HSQMADYIPA APPLVGSRDP DIKDRALLNG GTSVTEKLAQ LIATCPPSKS SKAKPKKLGT
     GTTVGLVSKD LIRKPGVGSI AGIIHKDLIK KPALSTAVGL VTKDPGKKPM FNAAVSLINK
     DSVKKLGTGT TAVFINKDLG KKPGTVTTVG LLSKDPGKKL GIGIVPGLVN KESGKKLGLG
     TVVGLVNKEL GKKLSSTVGL VAKDVTKKIV ASSAMGLVNK DIGKKLLSCP IAGQLGSKDA
     LNLKSEALLP TQEQLKASCS ANISNHESQE LPESLKDSAT SKTFEKNVMR HSKESMLEKF
     SVRKEITNLE KEMFNEGTCI QQDSFSSNER GAFETSKHEK QPPVYCTSPD FQIGGASDAS
     TAKSPFGAVG ESNLPSSSPT VSVNPLTRNP PETSSQLVPN PLLLNSTAEQ MEEISESIGK
     NQFTAESTHL NVGHRSLGHS ISIECKGIDK ELNESKSTHL DISRISSSLG KKPSLASDSG
     IHTITPSVVN FTSLFSNKPF LKLGAVAAPD KHCQVAESLS TSFQSKPLKK RKGRKARWTK
     VVARSTCRSP KGLDLERSEL FKNVSCSSLS NSSEPAKFMK TIGASSFVDH DFLKRRLPKL
     SKSSAPSLAL LADSEKASHK SFITHKLSSS MCVTSDLLSD IYKPKRGRPK SKEMPQLEGP
     PKRTLKIPAS KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK
     MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDTDDLEDSH RQSVCSVSDL
     EMEPDKKISK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL SSSVESSNKG KVQSKLHNTV
     SSLAATFGSK LGQQINVSKK GTIYIGKRRG RKPKTVLNGL LSGSPASLAV LEQTAQQAAG
     SALGQILPPL LPSPASSSEI LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHVHSRQ
     GSMIQTLAMK KAAKGRRRLS PPTLLPNSPS HLSELTSLKE ATPSPVSESH SDETIPSDSG
     IGTDNNSTSD RAEKFCGQKK RRHSFEHISL IPPETSTVLN SLKEKHKHKC KRRSHDYLSY
     DKMKRQKRKR KKKYPQLRNR QDPDFIAELE ELISRLSEIR ITHRSHHFIP RDLLPTIFRI
     NFNSFYTHPS FPLDPLHYIR KPDLKKKRGR PPKMREAMAE MPFMHSLSFP LSSTGFYPSY
     GMPYSPSPLT AAPIGLGYYG RYPPTLYPPP PSPSFTTPLP PPSYMHAGHL LLNPTKYHKK
     KHKLLRQEAF LTTSRTPLLS MSTYPSVPPE MAYGWMVEHK HRHRHKHREH RSEQPQVSMD
     TGSSRSVLES LKRYRFGKDT VGDRYKHKEK HRCHMSCPHL SPSKSLINRE EQWVSREPSE
     SSSLALGLQT PLQIDCSESS PSLSLGGFTP NSEPASSDEH MNLFTSAIGS CRVSNPNSSC
     RKKLTDSPGL FPVQDTALSR PHRKEPLPST ERAIQSLAGS QSASDKPSQR SSESTNCSPT
     RKRSSSESTS STVNGIPSRS PRLVASLDDS VDCLLQRIVQ HDEQESVEKN GDAPITTVSA
     PPSSSPGHSY SKERTLGKSD SLLVPAVPSD SCNSIPLLSE KLASRCSPHH IKRSVVEAMQ
     RQARKMCNYD KILATKKNLD HVNKILKAKK LQRQARTGNN FVKRRPGRPR KCPLQAVVSM
     QAFQAAQFVN PELNEGEEVS LHLSPDTVTD VIEAVVQSVN LNSEHKKGWK RKNWLLEEQT
     RKKQKTVPEE EEQENNKSFI EKPVEIPSPL ETPAEPSEPE SNLQPVLALI PREKKAPRPP
     KKKYQRAGLY SDVYKTTDPK SRLIQLKKEK LEYTPGEHEY GLFPAPIHVD VYVDVKPLSG
     YEATTCNCKK PDDDTRKGCG DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF
     RAEEKGWGIR TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID
     SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDV PAGTELTYDY NFHSFNVEKQ
     QLCKCGFEKC RGIIGGKSQR MNGLPSHKGS QPASTHRKSA RSKEKRKSKH KLKKRRGHPS
     EEPSENINTP TRLTPQLQMK PMSNRERNFV LKHHVFLVRN WEKIHQKQEE VKHSRDIHST
     SLYTRWNGIC RDDGNIKSDV FMTQFSALQT ARSVRTRRLA AAEENLEVAR AARLAQIFKE
     ICDGIISYKD SSQQALAAPL LNLPPKKKNA DYYEKISDPL DLSTIEKQIL TGYYKTVEAF
     DADMLKVFRN AEKYYGRKSP IGRDVCRLRK AYYSARHEAS AQIDEIVGET ASEADSSETS
     VSEKENSHEK DDDVIRCICG LYKDEGLMIQ CDKCMVWQHC DCMGVNTDVE HYLCEQCDPR
     PVDREVPMIP RPHYAQPGCV YFICLLRDDL LLRQGDCVYL MRDSRRTPDG HPVRQSYRLL
     SHINRDKLDI FRIEKLWKNE KEERFAFGHH YFRPHETHHS PSRRFYHNEL FRVPLYEIIP
     LEAVVGTCCV LDLYTYCKGR PKGVKEQDVY ICDYRLDKSA HLFYKIHRNR YPVCTKPYAF
     DHFPKKLTPK RDFSPHYVPD NYKRNGGRSS WKSERSKPLL KDLGQDDDAL PLIEEVLASQ
     EQAANEMPSP EEPDQERVTG DVSDAEKKPE ESSQEPQLAS TPEERRHSQR ERLNQILLNL
     LEKIPGKNAI DVTYLLEEGS GRKLRRRTLF IPENSFRK
//
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