ID A0A0G4JWD2_9GAMM Unreviewed; 511 AA.
AC A0A0G4JWD2;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Inner membrane component of tripartite multidrug resistance system {ECO:0000313|EMBL:CPR17499.1};
DE SubName: Full=Multidrug resistance protein B {ECO:0000313|EMBL:ATA22776.1};
GN Name=emrB {ECO:0000313|EMBL:ATA22776.1};
GN ORFNames=AWC36_00875 {ECO:0000313|EMBL:ATA22776.1}, BN1221_02676c
GN {ECO:0000313|EMBL:CPR17499.1};
OS Brenneria goodwinii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Brenneria.
OX NCBI_TaxID=1109412 {ECO:0000313|EMBL:CPR17499.1, ECO:0000313|Proteomes:UP000044377};
RN [1] {ECO:0000313|Proteomes:UP000044377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OBR1 {ECO:0000313|Proteomes:UP000044377};
RA Paterson Steve;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CPR17499.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OBR1 {ECO:0000313|EMBL:CPR17499.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ATA22776.1, ECO:0000313|Proteomes:UP000217214}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FRB141 {ECO:0000313|EMBL:ATA22776.1,
RC ECO:0000313|Proteomes:UP000217214};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000256|ARBA:ARBA00008537}.
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DR EMBL; CP014137; ATA22776.1; -; Genomic_DNA.
DR EMBL; CGIG01000001; CPR17499.1; -; Genomic_DNA.
DR RefSeq; WP_048637701.1; NZ_MJLX01000082.1.
DR AlphaFoldDB; A0A0G4JWD2; -.
DR STRING; 1109412.BN1221_02676c; -.
DR GeneID; 70905323; -.
DR KEGG; bgj:AWC36_00875; -.
DR OrthoDB; 9812221at2; -.
DR Proteomes; UP000044377; Unassembled WGS sequence.
DR Proteomes; UP000217214; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17503; MFS_LmrB_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000044377};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..511
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014227487"
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..503
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 511 AA; 55649 MW; 1299E0172CC5B25C CRC64;
MQRKPLKGAS LAWMTVALSL ATFMQVLDST IANVAIPTIA GNLGASNSQG TWVITSFGVA
NAISIPITGW LAKRFGEVRL FLLSTALFAF TSWMCGISSS LEMLIFARVL QGIVAGPLIP
LSQSLLLNNY PPARRSIALA LWSMTVVVAP ICGPILGGWI SDNYHWGWIF FINVPLGVAV
VVITLQTLRG RETKTEIKPI DTVGLALLIV GIGSLQMMLD RGKELDWFNS NEIIILTVIA
VITLTFLIVW ELTDDHPVVD LSLFKSRNFT IGCLCLSLAY MFYFGAIVLL PQLLQEVYGY
TATWAGLASA PVGLMPVVLS PIIGRFAPRL DMRQLVTFSF IMYAVCFYWR AYTFEPGMDF
GASAWPQFVQ GFAVACFFMP LTTITLSGLP PERMAAASSL SNFTRTLAGS IGTSITTTLW
AQRESLHHAH LTESITPYNP QAQEAYQQLQ QTLGMSQSQA SSYIASEITA QGLIISANEI
FWAAAAVFLM LLVLVWFARP PFTSGGGGGA H
//
