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Database: UniProt/TrEMBL
Entry: A0A0G9F868_LACPN
LinkDB: A0A0G9F868_LACPN
Original site: A0A0G9F868_LACPN 
ID   A0A0G9F868_LACPN        Unreviewed;       192 AA.
AC   A0A0G9F868;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   22-NOV-2017, entry version 21.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   ORFNames=A8P51_10550 {ECO:0000313|EMBL:ANM74830.1}, AVR82_09050
GN   {ECO:0000313|EMBL:AOB19761.1}, AYO51_12220
GN   {ECO:0000313|EMBL:KYK53890.1}, BIZ32_09625
GN   {ECO:0000313|EMBL:ARO05050.1}, LPJSA22_02201
GN   {ECO:0000313|EMBL:ODO62196.1}, Nizo2891_0529
GN   {ECO:0000313|EMBL:KZU81492.1}, SRCM101060_01707
GN   {ECO:0000313|EMBL:OAZ74666.1}, WP50_23730
GN   {ECO:0000313|EMBL:KLD58773.1};
OS   Lactobacillus plantarum.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1590 {ECO:0000313|EMBL:KLD58773.1, ECO:0000313|Proteomes:UP000035430};
RN   [1] {ECO:0000313|EMBL:KLD58773.1, ECO:0000313|Proteomes:UP000035430}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=38 {ECO:0000313|EMBL:KLD58773.1,
RC   ECO:0000313|Proteomes:UP000035430};
RA   Gorlova I.S., Kulchitskaya M.A., Pronova M.A., Golubeva N.A.,
RA   Solovyeva I.V., Tochilina A.G., Belova I.V.;
RT   "Lactobacillus plantarum strain 38 whole genome sequence.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AOB19761.1, ECO:0000313|Proteomes:UP000093269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP {ECO:0000313|EMBL:AOB19761.1,
RC   ECO:0000313|Proteomes:UP000093269};
RA   Petkau K., Fast D., Duggal A., Foley E.;
RT   "Comparative evaluation of the genomes of common bacterial members of
RT   the Drosophila intestinal community.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KZU81492.1, ECO:0000313|Proteomes:UP000076745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nizo2891 {ECO:0000313|EMBL:KZU81492.1,
RC   ECO:0000313|Proteomes:UP000076745};
RA   Martino M.E.;
RT   "Comparative genomics of 54 Lactobacillus plantarum strains reveals
RT   genomic uncoupling from niche constraints.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:KYK53890.1, ECO:0000313|Proteomes:UP000075744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2C2 {ECO:0000313|EMBL:KYK53890.1,
RC   ECO:0000313|Proteomes:UP000075744};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OAZ74666.1, ECO:0000313|Proteomes:UP000093664}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRCM101060 {ECO:0000313|EMBL:OAZ74666.1,
RC   ECO:0000313|Proteomes:UP000093664};
RA   Song Y.R.;
RT   "Genome sequencing of Lactobacillus plantarum strain SRCM101060.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:ANM74830.1, ECO:0000313|Proteomes:UP000078583}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCU116 {ECO:0000313|EMBL:ANM74830.1,
RC   ECO:0000313|Proteomes:UP000078583};
RA   Huang T., Xiong T.;
RT   "Lactobacillus plantarum NCU116 Genome sequencing and assembly
RT   isolated from Chinese pickle.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:ODO62196.1, ECO:0000313|Proteomes:UP000094892}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSA22 {ECO:0000313|EMBL:ODO62196.1,
RC   ECO:0000313|Proteomes:UP000094892};
RA   Choi H.S.;
RT   "Genome sequencing of Lactobacillus plantarum JSA22, isolated from
RT   fermented soybean paste.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ARO05050.1, ECO:0000313|Proteomes:UP000193023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMW 1.277 {ECO:0000313|EMBL:ARO05050.1,
RC   ECO:0000313|Proteomes:UP000193023};
RA   Kafka T.A., Vogel R.F.;
RT   "Lactobacillus species Genome sequencing and assembly.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; CP016071; ANM74830.1; -; Genomic_DNA.
DR   EMBL; CP013749; AOB19761.1; -; Genomic_DNA.
DR   EMBL; CP017363; ARO05050.1; -; Genomic_DNA.
DR   EMBL; LBDE01001547; KLD58773.1; -; Genomic_DNA.
DR   EMBL; LSST01000011; KYK53890.1; -; Genomic_DNA.
DR   EMBL; LUXG01000005; KZU81492.1; -; Genomic_DNA.
DR   EMBL; LYUK01000040; OAZ74666.1; -; Genomic_DNA.
DR   EMBL; MCOL01000001; ODO62196.1; -; Genomic_DNA.
DR   RefSeq; WP_003644660.1; NZ_NKRH01000013.1.
DR   EnsemblBacteria; ANM74830; ANM74830; A8P51_10550.
DR   EnsemblBacteria; KLD58773; KLD58773; WP50_23730.
DR   EnsemblBacteria; KYK53890; KYK53890; AYO51_12220.
DR   EnsemblBacteria; KZU81492; KZU81492; Nizo2891_0529.
DR   EnsemblBacteria; OAZ74666; OAZ74666; SRCM101060_01707.
DR   EnsemblBacteria; ODO62196; ODO62196; LPJSA22_02201.
DR   KEGG; lpb:SH83_10195; -.
DR   PATRIC; fig|1590.144.peg.2095; -.
DR   KO; K00857; -.
DR   Proteomes; UP000035430; Unassembled WGS sequence.
DR   Proteomes; UP000075744; Unassembled WGS sequence.
DR   Proteomes; UP000076745; Unassembled WGS sequence.
DR   Proteomes; UP000078583; Chromosome.
DR   Proteomes; UP000093269; Chromosome.
DR   Proteomes; UP000093664; Unassembled WGS sequence.
DR   Proteomes; UP000094892; Unassembled WGS sequence.
DR   Proteomes; UP000193023; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035430,
KW   ECO:0000313|Proteomes:UP000075744, ECO:0000313|Proteomes:UP000076745,
KW   ECO:0000313|Proteomes:UP000078583};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:KLD58773.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:KLD58773.1};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND       9     16       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      85     88       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     86     86       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       143    143       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       146    146       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       180    180       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       183    183       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   192 AA;  22147 MW;  FB4E51939625CEBC CRC64;
     MAQLFFRYGA MNSGKTIEIL KVAHNYEEQD KSVIILTSGL DNRDGVGYVA SRIGLKREAT
     PVFDDTNIFE IVKQTNPDAA CVLIDEAQFL KKHHVLELAD IVDELKIPVM TFGLKNDFRN
     ELFEGSKYLL LYADKIEEMK TICWFCRKKA IMNLRFHDGQ PVYEGEQVQI GGNEAYYPVC
     RHHYFYPPKL TK
//
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