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Database: UniProt/TrEMBL
Entry: A0A0H3DJ00_AMYMU
LinkDB: A0A0H3DJ00_AMYMU
Original site: A0A0H3DJ00_AMYMU 
ID   A0A0H3DJ00_AMYMU        Unreviewed;      1216 AA.
AC   A0A0H3DJ00;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 10.
DE   SubName: Full=2-oxoglutarate decarboxylase {ECO:0000313|EMBL:ADJ49654.1};
GN   Name=kgd {ECO:0000313|EMBL:ADJ49654.1};
GN   OrderedLocusNames=AMED_7949 {ECO:0000313|EMBL:ADJ49654.1};
OS   Amycolatopsis mediterranei (strain U-32).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Amycolatopsis.
OX   NCBI_TaxID=749927 {ECO:0000313|EMBL:ADJ49654.1, ECO:0000313|Proteomes:UP000000328};
RN   [1] {ECO:0000313|EMBL:ADJ49654.1, ECO:0000313|Proteomes:UP000000328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U-32 {ECO:0000313|Proteomes:UP000000328};
RX   PubMed=20567260; DOI=10.1038/cr.2010.87;
RA   Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F.,
RA   Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N.,
RA   Zhang Z., Zhang Y., Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S.,
RA   Ding X., Zhao G.P.;
RT   "Complete genome sequence of the rifamycin SV-producing Amycolatopsis
RT   mediterranei U32 revealed its genetic characteristics in phylogeny and
RT   metabolism.";
RL   Cell Res. 20:1096-1108(2010).
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DR   EMBL; CP002000; ADJ49654.1; -; Genomic_DNA.
DR   RefSeq; WP_013229688.1; NC_014318.1.
DR   RefSeq; YP_003770056.1; NC_014318.1.
DR   STRING; 749927.AMED_7949; -.
DR   EnsemblBacteria; ADJ49654; ADJ49654; AMED_7949.
DR   GeneID; 9442090; -.
DR   KEGG; amd:AMED_7949; -.
DR   PATRIC; fig|749927.5.peg.8261; -.
DR   KO; K01616; -.
DR   OMA; IDMVCYR; -.
DR   Proteomes; UP000000328; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000328}.
FT   DOMAIN      875   1068       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
FT   COILED      785    812       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1216 AA;  133940 MW;  20F429773F3ADAEC CRC64;
     MYDQFLADPS SVDAAWHDFF ADFKPTQSAQ AKADTARQQQ AGAKPAANGQ AAQPSAKAVQ
     NAESAAKQSS TAPAAKPAPA KAAPKQAPKP AAKAEPKAEA KKEEPESKQL RGAAAAIAKN
     MDASLSVPTA TSVRAVPAKL MADNRIVINN HLKRTRGGKI SFTHLIGYAM VRALKAYPNM
     NRHYQLIDGK PFAITPEHVN FGLAIDMKGK DGSRTLVVAS IKGCEDMSFL QFWQAYEDIV
     KKARNNKLTA DDFSGTTISL TNPGGIGTNH SVPRLQAGQG AIIGVGAMQY PAAFEGTSEK
     TLVDLGISKI MTLTSTYDHR IIQGAESGEF LKRIHQLLLG EDGFYDDVFT SLRLPYEPIR
     WVADIPDGPV DKTARVIELI DAFRMRGHLM ADTDPLNYRQ RSHADLDVLS HGLTLWDLDR
     EFPVGGFAGQ ERMKLRDILG VLRNSYCRTV GIEYTHILDP EERRWIQERV EIPHEKPDPA
     VQKYVLSKLN AAEAFETFLQ TKYVGQKRFS LEGGETAIPL LDTILDKAAE HELDEVVIGM
     PHRGRLNVLA NIVGKPISQI FQEFEGNLDP GQAHGSGDVK YHLGAEGKYF RMFGDGETKV
     SLTANPSHLE TVDPVLEGIV RAKQDILDKG GEGYTVLPVL MHGDAAFAGQ GVVAETLNLS
     LLRGYRTGGT VHVIVNNQVG FTTAPEHSRS SQYATDVAKM IGSPIFHVNG DDPEAAHWVA
     KLAVEYRQAF HKDVVIDLIC YRRRGHNEGD DPSMTQPAMY DIIDTKRSVR KTYTESLIGR
     GDISVEEAEA ALRDFSSQLE HVFNEVRELE KHPAKASPSV EEEQQVPAKV ATAITGKTLE
     HIGDAFVNVP DGFTPHPRVK PVMERRHKMS REGDIDWAFG ELLAFGSLAM EGRLVRLSGQ
     DSRRGTFTQR HSVFIDRKTG QEYSPLQNLA DGQGRVMIYD SALSEYAAVG FEYGYSVANP
     ESLVMWEAQF GDFVNGAQTV IDEYISSGEA KWGQRSDVVL LLPHGHEGQG PDHTSGRIER
     FLSLCAEGSM TVAVPSTPAN YFHLLRRHAL DGIQRPLVVF TPKSMLRNKA ATSPTEDFTG
     ESRFMSVIDD VTPDPAKIRK VLLTSGKLYW ELVAERTKRE ADDVAIVRIE QYYPLPKKKL
     LAALERYTNA TQVAWVQEEP ENQGAWPFFG LNLPRKFPEV LSGLQVVSRR PMAAPSAGSS
     KVHEVEQKAL IAKAFD
//
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