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Database: UniProt/TrEMBL
Entry: A0A0H6HAH5_VIBCL
LinkDB: A0A0H6HAH5_VIBCL
Original site: A0A0H6HAH5_VIBCL 
ID   A0A0H6HAH5_VIBCL        Unreviewed;       548 AA.
AC   A0A0H6HAH5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   SubName: Full=Glutamate decarboxylase {ECO:0000313|EMBL:CSB55785.1};
DE            EC=4.1.1.86 {ECO:0000313|EMBL:CSB55785.1};
GN   Name=ddc_1 {ECO:0000313|EMBL:CSB55785.1};
GN   Synonyms=ddc_2 {ECO:0000313|EMBL:CSC99804.1};
GN   ORFNames=B2J67_06065 {ECO:0000313|EMBL:OWO83508.1}, B2J70_06140
GN   {ECO:0000313|EMBL:OWO69352.1}, B2J71_05760
GN   {ECO:0000313|EMBL:OWO78124.1}, BTY66_06130
GN   {ECO:0000313|EMBL:OQM90997.1}, CEF09_03565
GN   {ECO:0000313|EMBL:OXB32712.1}, EN12_05630
GN   {ECO:0000313|EMBL:AKO74721.1}, ERS013193_00760
GN   {ECO:0000313|EMBL:CSB48351.1}, ERS013198_00403
GN   {ECO:0000313|EMBL:CSB48515.1}, ERS013199_01031
GN   {ECO:0000313|EMBL:CSC21096.1}, ERS013200_02844
GN   {ECO:0000313|EMBL:CSC99804.1}, ERS013202_00258
GN   {ECO:0000313|EMBL:CSB50171.1}, ERS013206_00264
GN   {ECO:0000313|EMBL:CSB55785.1};
OS   Vibrio cholerae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=666 {ECO:0000313|EMBL:CSB55785.1, ECO:0000313|Proteomes:UP000040416};
RN   [1] {ECO:0000313|EMBL:AKO74721.1, ECO:0000313|Proteomes:UP000036184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TSY216 {ECO:0000313|EMBL:AKO74721.1,
RC   ECO:0000313|Proteomes:UP000036184};
RX   PubMed=26079534; DOI=10.3201/eid2107.141055;
RA   Okada K., Natakuathung W., Na-Ubol M., Roobthaisong A., Wongboot W.,
RA   Maruyama F., Nakagawa I., Chantaroj S., Hamada S.;
RT   "Characterization of 3 Megabase-Sized Circular Replicons from Vibrio
RT   cholerae.";
RL   Emerg. Infect. Dis. 21:1262-1263(2015).
RN   [2] {ECO:0000313|Proteomes:UP000040416, ECO:0000313|Proteomes:UP000041770, ECO:0000313|Proteomes:UP000043173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A217 {ECO:0000313|EMBL:CSB48351.1,
RC   ECO:0000313|Proteomes:UP000043173}, A316 {ECO:0000313|EMBL:CSC99804.1,
RC   ECO:0000313|Proteomes:UP000041770}, A346
RC   {ECO:0000313|EMBL:CSB50171.1}, A346(2)
RC   {ECO:0000313|Proteomes:UP000043247}, A481
RC   {ECO:0000313|EMBL:CSB55785.1, ECO:0000313|Proteomes:UP000040416}, A483
RC   {ECO:0000313|EMBL:CSB48515.1, ECO:0000313|Proteomes:UP000043560}, A487
RC   {ECO:0000313|EMBL:CSC21096.1}, and A487(2)
RC   {ECO:0000313|Proteomes:UP000045578};
RA   Informatics Pathogen;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:OQM90997.1, ECO:0000313|Proteomes:UP000192124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7714 {ECO:0000313|EMBL:OQM90997.1,
RC   ECO:0000313|Proteomes:UP000192124};
RX   PubMed=28219321;
RA   Kachwamba Y., Mohammed A.A., Lukupulo H., Urio L., Majigo M.,
RA   Mosha F., Matonya M., Kishimba R., Mghamba J., Lusekelo J., Nyanga S.,
RA   Almeida M., Li S., Domman D., Massele S.Y., Stine O.C.;
RT   "Genetic Characterization of Vibrio cholerae O1 isolates from
RT   outbreaks between 2011 and 2015 in Tanzania.";
RL   BMC Infect. Dis. 17:157-157(2017).
RN   [4] {ECO:0000313|EMBL:OWO83508.1, ECO:0000313|Proteomes:UP000197575}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39 {ECO:0000313|EMBL:OWO83508.1,
RC   ECO:0000313|Proteomes:UP000197575};
RA   Agafonova E.Y., Krasnov Y.M., Alkhova Z.V., Shchelkanova E.Y.,
RA   Smirnova N.I., Kutyrev V.;
RT   "The outbreak of cholera in Mariupol in 2011.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OWO78124.1, ECO:0000313|Proteomes:UP000197712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=866 {ECO:0000313|EMBL:OWO78124.1,
RC   ECO:0000313|Proteomes:UP000197712};
RA   Agafonova E.Y., Krasnov Y.M., Alkhova Z.V., Shchelkanova E.Y.,
RA   Smirnova N.I., Kutyrev V.;
RT   "Cholera in Crimea.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:OWO69352.1, ECO:0000313|Proteomes:UP000197879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=153 {ECO:0000313|EMBL:OWO69352.1,
RC   ECO:0000313|Proteomes:UP000197879};
RA   Agafonova E.Y., Krasnov Y.M., Alkhova Z.V., Shchelkanova E.Y.,
RA   Smirnova N.I., Kutyrev V.;
RT   "The outbreak of cholera in Mariupol in 2011.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:OXB32712.1, ECO:0000313|Proteomes:UP000198441}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W4-13 {ECO:0000313|EMBL:OXB32712.1,
RC   ECO:0000313|Proteomes:UP000198441};
RA   Narendrakumar L., Thomas S., Reghunathan D.;
RT   "Draft genome sequence of Haitian variant Vibrio cholerae isolated
RT   from Kerala, south India.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602129-50,
CC         ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CP007653; AKO74721.1; -; Genomic_DNA.
DR   EMBL; CWPV01000002; CSB48351.1; -; Genomic_DNA.
DR   EMBL; CWQA01000002; CSB48515.1; -; Genomic_DNA.
DR   EMBL; CWQG01000001; CSB50171.1; -; Genomic_DNA.
DR   EMBL; CWQD01000001; CSB55785.1; -; Genomic_DNA.
DR   EMBL; CWQX01000008; CSC21096.1; -; Genomic_DNA.
DR   EMBL; CWQY01000021; CSC99804.1; -; Genomic_DNA.
DR   EMBL; MSEO01000004; OQM90997.1; -; Genomic_DNA.
DR   EMBL; MWRE01000069; OWO69352.1; -; Genomic_DNA.
DR   EMBL; MWRF01000122; OWO78124.1; -; Genomic_DNA.
DR   EMBL; MWRC01000282; OWO83508.1; -; Genomic_DNA.
DR   EMBL; NIWX01000007; OXB32712.1; -; Genomic_DNA.
DR   RefSeq; WP_000253201.1; NZ_NIFI01000002.1.
DR   EnsemblBacteria; AKO74721; AKO74721; EN12_05630.
DR   EnsemblBacteria; CSB39527; CSB39527; ERS013207_00284.
DR   EnsemblBacteria; CSB48351; CSB48351; ERS013193_00760.
DR   EnsemblBacteria; CSB48515; CSB48515; ERS013198_00403.
DR   EnsemblBacteria; CSB50171; CSB50171; ERS013202_00258.
DR   EnsemblBacteria; CSB55785; CSB55785; ERS013206_00264.
DR   EnsemblBacteria; CSC21096; CSC21096; ERS013199_01031.
DR   EnsemblBacteria; CSC99804; CSC99804; ERS013200_02844.
DR   KEGG; vcq:EN18_09065; -.
DR   PATRIC; fig|666.1969.peg.2454; -.
DR   KO; K01580; -.
DR   Proteomes; UP000036184; Chromosome 1.
DR   Proteomes; UP000040416; Unassembled WGS sequence.
DR   Proteomes; UP000041770; Unassembled WGS sequence.
DR   Proteomes; UP000043173; Unassembled WGS sequence.
DR   Proteomes; UP000043247; Unassembled WGS sequence.
DR   Proteomes; UP000043560; Unassembled WGS sequence.
DR   Proteomes; UP000045578; Unassembled WGS sequence.
DR   Proteomes; UP000192124; Unassembled WGS sequence.
DR   Proteomes; UP000197575; Unassembled WGS sequence.
DR   Proteomes; UP000197712; Unassembled WGS sequence.
DR   Proteomes; UP000197879; Unassembled WGS sequence.
DR   Proteomes; UP000198441; Unassembled WGS sequence.
DR   GO; GO:0033983; F:diaminobutyrate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR022517; Asp_decarboxylase_pyridox.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_sub2.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR03799; NOD_PanD_pyr; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000036184,
KW   ECO:0000313|Proteomes:UP000040416, ECO:0000313|Proteomes:UP000041770,
KW   ECO:0000313|Proteomes:UP000043173};
KW   Lyase {ECO:0000256|RuleBase:RU000382, ECO:0000313|EMBL:CSB55785.1};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES     338    338       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000256|PIRSR:PIRSR602129-50}.
SQ   SEQUENCE   548 AA;  61693 MW;  DCBFD48556AF50B2 CRC64;
     MVSEHKSAQV NFDSLLKIFT VPEGPDSTLT KIDEELSRNL NHFLRKHIVA EEKPLKEIEK
     DFSNAHIPEQ PQFVSDHTQY LLDTLVSHSV HTASPSFIGH MTSALPYFLM PLSKIMIALN
     QNLVKIETSK AFTPLERQVL GMIHRLIYGE TDHFYQQWMH SAEHSLGAFC SGGTIANITA
     LWVARNNALK AEGDFPGVEK AGLFKAMRHY GHEGLAILVS ERGHYSLKKA ADVLGIGQEG
     LVAVKTDAHN RICPHDLEQK ITELKANKIK VFAVVGVAGT TETGNIDPLR TIAQICQREQ
     IHFHIDAAWG GATLMSNRYR GLLDGVELAD SVTIDAHKQL YIPMGAGMVL FKDPNAMRSI
     EHHAQYILRQ GSKDLGSHTL EGSRSGMAML VYASMHIISR PGYQLLIDQS IEKARYFADL
     IDAQTDFELV SQPELCLLTY RYLPEHVRMA LEKSQGVQRA QLNELLNELT KFIQKKQRET
     GKSFVSRTQL NPHQWDKLAT IVFRVVLANP LTTKEILHNV LDEQREIAQQ APKLMRQIEH
     LTQCILNQ
//
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