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Database: UniProt/TrEMBL
Entry: A0A0M4STJ9_9PROT
LinkDB: A0A0M4STJ9_9PROT
Original site: A0A0M4STJ9_9PROT 
ID   A0A0M4STJ9_9PROT        Unreviewed;       346 AA.
AC   A0A0M4STJ9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   RecName: Full=D-alanine--D-alanine ligase {ECO:0000256|SAAS:SAAS00754435};
DE            EC=6.3.2.4 {ECO:0000256|SAAS:SAAS00754435};
GN   Name=ddlA {ECO:0000313|EMBL:ALF47733.1};
GN   ORFNames=CCON33237_1058 {ECO:0000313|EMBL:ALF47733.1};
OS   Campylobacter concisus.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=199 {ECO:0000313|EMBL:ALF47733.1, ECO:0000313|Proteomes:UP000066049};
RN   [1] {ECO:0000313|Proteomes:UP000066049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33237 {ECO:0000313|Proteomes:UP000066049};
RA   Miller W.G., Yee E., Chapman M.H., Huynh S., Bono J.L., On S.L.W.,
RA   St Leger J., Foster G., Parker C.T.;
RT   "Comparative genomics of the Campylobacter concisus group.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell wall formation. {ECO:0000256|SAAS:SAAS00754456}.
CC   -!- CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-
CC       alanyl-D-alanine. {ECO:0000256|SAAS:SAAS00754451}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00754472};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|SAAS:SAAS00754454};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|SAAS:SAAS00754475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00644680}.
CC   -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC       {ECO:0000256|SAAS:SAAS00644812}.
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DR   EMBL; CP012541; ALF47733.1; -; Genomic_DNA.
DR   RefSeq; WP_054196721.1; NZ_CP012541.1.
DR   EnsemblBacteria; ALF47733; ALF47733; CCON33237_1058.
DR   GeneID; 28662736; -.
DR   KEGG; ccoc:CCON33237_1058; -.
DR   PATRIC; fig|199.248.peg.1097; -.
DR   KO; K01921; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000066049; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR000291; D-Ala_lig_Van_CS.
DR   InterPro; IPR005905; D_ala_D_ala.
DR   InterPro; IPR011095; Dala_Dala_lig_C.
DR   InterPro; IPR011127; Dala_Dala_lig_N.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   Pfam; PF07478; Dala_Dala_lig_C; 1.
DR   Pfam; PF01820; Dala_Dala_lig_N; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00644673};
KW   Cell shape {ECO:0000256|SAAS:SAAS00644718};
KW   Cell wall biogenesis/degradation {ECO:0000256|SAAS:SAAS00644792};
KW   Complete proteome {ECO:0000313|Proteomes:UP000066049};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00754427};
KW   Ligase {ECO:0000256|SAAS:SAAS00644741, ECO:0000313|EMBL:ALF47733.1};
KW   Magnesium {ECO:0000256|SAAS:SAAS00754439};
KW   Manganese {ECO:0000256|SAAS:SAAS00754447};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00754442};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00644705};
KW   Peptidoglycan synthesis {ECO:0000256|SAAS:SAAS00644714}.
FT   DOMAIN      133    326       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   346 AA;  39434 MW;  A2A38ABF194824BF CRC64;
     MNLGVIFGAK SYEHEISIVS AIVLKNVLKQ ELKFIFCDAN RDFYLIEQKD MRANFFSSGK
     YKNSKKLILS KGGFFIHSLF GDKKVECDVI INLIHGMDGE DGKIAALFDF YGIKYIGPRL
     EVSALSYNKE LTKFLAQKAG VKALDYEMLT RQSEPKFHYP IILKPARLGS SIGVNIVHDA
     SELAYAKDVA FEFDKDVLVE PFIKGVKEYN LAGCKIDGKI KFSIIEEPKK KEFLDYEQKY
     LSFSNENKVK EAEISEELKQ KLKFNFSKIY DCGFDGAIIR CDFFMIDDEV YLNEINPNPG
     SLANYLFEDF ESTLNALANS LPRERNIKID YSFINSITSV KGRGKI
//
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