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Database: UniProt/TrEMBL
Entry: A0A0M4TLQ2_9PROT
LinkDB: A0A0M4TLQ2_9PROT
Original site: A0A0M4TLQ2_9PROT 
ID   A0A0M4TLQ2_9PROT        Unreviewed;       399 AA.
AC   A0A0M4TLQ2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   22-NOV-2017, entry version 18.
DE   RecName: Full=Elongation factor Tu {ECO:0000256|HAMAP-Rule:MF_00118, ECO:0000256|RuleBase:RU004061};
DE            Short=EF-Tu {ECO:0000256|HAMAP-Rule:MF_00118};
GN   Name=tuf {ECO:0000256|HAMAP-Rule:MF_00118,
GN   ECO:0000313|EMBL:ALF47369.1};
GN   ORFNames=A3223_02050 {ECO:0000313|EMBL:ORI04319.1}, A3835_03810
GN   {ECO:0000313|EMBL:ORI08655.1}, B9N62_06180
GN   {ECO:0000313|EMBL:OUT11572.1}, B9N63_02230
GN   {ECO:0000313|EMBL:OUT15130.1}, CCON33237_0678
GN   {ECO:0000313|EMBL:ALF47369.1}, CCON61_02085
GN   {ECO:0000313|EMBL:OSQ25484.1}, TH67_06450
GN   {ECO:0000313|EMBL:OJJ28386.1};
OS   Campylobacter concisus.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=199 {ECO:0000313|EMBL:ALF47369.1, ECO:0000313|Proteomes:UP000066049};
RN   [1] {ECO:0000313|EMBL:OJJ28386.1, ECO:0000313|Proteomes:UP000183950}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMIT-JF1 {ECO:0000313|EMBL:OJJ28386.1,
RC   ECO:0000313|Proteomes:UP000183950};
RA   Huq M., Van T.T.H., Smooker P.M., Istivan T.S.;
RT   "Whole genome sequencing of Campylobacter concisus, an oral isolate
RT   from a Crohn's disease patient.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000066049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33237 {ECO:0000313|Proteomes:UP000066049};
RA   Miller W.G., Yee E., Chapman M.H., Huynh S., Bono J.L., On S.L.W.,
RA   St Leger J., Foster G., Parker C.T.;
RT   "Comparative genomics of the Campylobacter concisus group.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ALF47369.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 33237 {ECO:0000313|EMBL:ALF47369.1};
RA   Miller W.G., Yee E., Chapman M.H., Huynh S., Bono J.L., On S.L.W.,
RA   StLeger J., Foster G., Parker C.T.;
RT   "Comparative genomics of the Campylobacter concisus group.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ORI04319.1, ECO:0000313|Proteomes:UP000192671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCH 26 {ECO:0000313|EMBL:ORI08655.1,
RC   ECO:0000313|Proteomes:UP000192671}, and RMIT-O17
RC   {ECO:0000313|EMBL:ORI04319.1};
RA   Huq M., Van T.T.H., Gurtler V., Elshagmani E., Allemailem K.S.,
RA   Smooker P.M., Istivan T.S.;
RT   "The ribosomal RNA operon (rrn) of Campylobacter concisus supports
RT   molecular typing to genomospecies level.";
RL   Gene Rep 6:8-14(2017).
RN   [5] {ECO:0000313|Proteomes:UP000193227, ECO:0000313|Proteomes:UP000195967, ECO:0000313|Proteomes:UP000196185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lasto28.99 {ECO:0000313|EMBL:OUT11572.1,
RC   ECO:0000313|Proteomes:UP000195967}, Lasto393.96
RC   {ECO:0000313|EMBL:OUT15130.1, ECO:0000313|Proteomes:UP000196185}, and
RC   Lasto61.99 {ECO:0000313|EMBL:OSQ25484.1,
RC   ECO:0000313|Proteomes:UP000193227};
RA   Cornelius A.J., Miller W.G., Lastovica A.J., On S.L., French N.P.,
RA   Vandenberg O., Biggs P.J.;
RT   "Complete genome of Campylobacter concisus ATCC 33237T and draft
RT   genomes for an additional eight well characterized C. concisus
RT   strains.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of
CC       aminoacyl-tRNA to the A-site of ribosomes during protein
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00118}.
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DR   EMBL; CP012541; ALF47369.1; -; Genomic_DNA.
DR   EMBL; JXUP01000006; OJJ28386.1; -; Genomic_DNA.
DR   EMBL; LVLC01000001; ORI04319.1; -; Genomic_DNA.
DR   EMBL; LVWL01000018; ORI08655.1; -; Genomic_DNA.
DR   EMBL; NEFM01000004; OSQ25484.1; -; Genomic_DNA.
DR   EMBL; NDYO01000006; OUT11572.1; -; Genomic_DNA.
DR   EMBL; NDYT01000001; OUT15130.1; -; Genomic_DNA.
DR   RefSeq; WP_021090663.1; NZ_NEFM01000004.1.
DR   EnsemblBacteria; ALF47369; ALF47369; CCON33237_0678.
DR   GeneID; 28662352; -.
DR   KEGG; ccoc:CCON33237_0678; -.
DR   PATRIC; fig|199.248.peg.705; -.
DR   KO; K02358; -.
DR   Proteomes; UP000066049; Chromosome.
DR   Proteomes; UP000183950; Unassembled WGS sequence.
DR   Proteomes; UP000192388; Unassembled WGS sequence.
DR   Proteomes; UP000192671; Unassembled WGS sequence.
DR   Proteomes; UP000193227; Unassembled WGS sequence.
DR   Proteomes; UP000195967; Unassembled WGS sequence.
DR   Proteomes; UP000196185; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd03697; EFTU_II; 1.
DR   HAMAP; MF_00118_B; EF_Tu_B; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00485; EF-Tu; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000066049,
KW   ECO:0000313|Proteomes:UP000183950, ECO:0000313|Proteomes:UP000192388,
KW   ECO:0000313|Proteomes:UP000192671};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Elongation factor {ECO:0000256|HAMAP-Rule:MF_00118,
KW   ECO:0000313|EMBL:ALF47369.1};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Hydrolase {ECO:0000313|EMBL:OJJ28386.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Reference proteome {ECO:0000313|Proteomes:UP000066049}.
FT   DOMAIN       10    209       Tr-type G. {ECO:0000259|PROSITE:PS51722}.
FT   NP_BIND      19     26       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
FT   NP_BIND      81     85       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
FT   NP_BIND     136    139       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
SQ   SEQUENCE   399 AA;  43628 MW;  F78CC55D0262E563 CRC64;
     MAKEKFSRNK PHVNIGTIGH VDHGKTTLTA AISAVLSRKG LAELKDYDNI DNAPEEKERG
     ITIATSHIEY ETEKRHYAHV DCPGHADYVK NMITGAAQMD GAILVVSAAD GPMPQTREHI
     LLSRQVGVPY IVVFMNKADM VDDAELLELV EMEIRELLNE YNFPGDDTPI VSGSALKALE
     EAKAGQDGEW SAKIMELMDA VDSYIPTPVR ATDKDLLMPI EDVFSISGRG TVVTGRIEKG
     VIKVGDTIEI VGIKPTQTTT VTGVEMFRKE MDQGEAGDNV GVLLRGTKKE DVERGMVLCK
     PKSITPHTKF EGEVYILTKE EGGRHTPFFN NYRPQFYVRT TDVTGSITLP EGTEMVMPGD
     NVRISVELIA PVALEEGTRF AIREGGRTVG SGVVSKILG
//
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