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Database: UniProt/TrEMBL
Entry: A0A0N6ZF86_9ACTN
LinkDB: A0A0N6ZF86_9ACTN
Original site: A0A0N6ZF86_9ACTN 
ID   A0A0N6ZF86_9ACTN        Unreviewed;       739 AA.
AC   A0A0N6ZF86;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AIV32822.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AIV32822.1};
GN   ORFNames=NI25_04180 {ECO:0000313|EMBL:AIV32822.1};
OS   Streptomyces sp. CCM_MD2014.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1561022 {ECO:0000313|EMBL:AIV32822.1};
RN   [1] {ECO:0000313|Proteomes:UP000069932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM_MD2014 {ECO:0000313|Proteomes:UP000069932};
RA   Mariita R.M., Bhatgnagar S., Hanselmann K., Hossain M.J., Dawson S.C.,
RA   Korlach J., Boitano M., Liles M.R., Moss A.G., Leadbetter J.R.,
RA   Newman D.K.;
RT   "Isolation and characterization of species affiliated with family
RT   Actinomycetaceae.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP009754; AIV32822.1; -; Genomic_DNA.
DR   RefSeq; WP_061441137.1; NZ_CP009754.1.
DR   EnsemblBacteria; AIV32822; AIV32822; NI25_04180.
DR   PATRIC; fig|1561022.5.peg.887; -.
DR   Proteomes; UP000069932; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000069932};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AIV32822.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79369 MW;  DEFA58C744A9E2C0 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA LFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAIAEL QGQGYALPAY PDDPKTDEER
     DVRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTGESK TNVATMGEND
     FRSTEKSVVI AEDGALRIEL VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGETLAKAG LTPNDGLGGI
     YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS MPAMIRTSGH
     MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIAKV KAYLPEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
     SLGEFFALVP SLEQYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA GQTDDADLAK AFAPLAETLT ANEQKIVEEL NAVQGKPAEI GGYYQPDPAK
     AAKVMRPSAT WNEALASLA
//
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