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Database: UniProt/TrEMBL
Entry: A0A0N7GUR2_KLEPN
LinkDB: A0A0N7GUR2_KLEPN
Original site: A0A0N7GUR2_KLEPN 
ID   A0A0N7GUR2_KLEPN        Unreviewed;       394 AA.
AC   A0A0N7GUR2;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   30-AUG-2017, entry version 14.
DE   RecName: Full=Elongation factor Tu {ECO:0000256|HAMAP-Rule:MF_00118, ECO:0000256|RuleBase:RU004061};
DE            Short=EF-Tu {ECO:0000256|HAMAP-Rule:MF_00118};
GN   Name=tuf {ECO:0000256|HAMAP-Rule:MF_00118,
GN   ECO:0000313|EMBL:ALR25710.1};
GN   Synonyms=ef-tu {ECO:0000313|EMBL:CDO16225.1}, tuf1
GN   {ECO:0000313|EMBL:SLY46488.1}, tuf1_1 {ECO:0000313|EMBL:AIT00720.1},
GN   tuf1_2 {ECO:0000313|EMBL:AIT01316.1};
GN   ORFNames=AGG09_12930 {ECO:0000313|EMBL:ALR25102.1}, AGG09_16220
GN   {ECO:0000313|EMBL:ALR25710.1}, AM447_10645
GN   {ECO:0000313|EMBL:ARA46573.1}, AM447_14195
GN   {ECO:0000313|EMBL:ARA47218.1}, B5G58_21075
GN   {ECO:0000313|EMBL:ARM24278.1}, B5G58_24390
GN   {ECO:0000313|EMBL:ARM24877.1}, BN49_4482
GN   {ECO:0000313|EMBL:CDO16225.1}, PMK1_01228
GN   {ECO:0000313|EMBL:AIT00720.1}, PMK1_01841
GN   {ECO:0000313|EMBL:AIT01316.1}, SAMEA3304684_04946
GN   {ECO:0000313|EMBL:SLP40627.1}, SAMEA3531848_05140
GN   {ECO:0000313|EMBL:SBY72087.1}, SAMEA4362680_04940
GN   {ECO:0000313|EMBL:SLY46488.1}, SM57_03967
GN   {ECO:0000313|EMBL:KMW85930.1}, SM57_04595
GN   {ECO:0000313|EMBL:KMW82807.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:ALR25710.1, ECO:0000313|Proteomes:UP000067608};
RN   [1] {ECO:0000313|EMBL:AIT00720.1, ECO:0000313|Proteomes:UP000029666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PMK1 {ECO:0000313|EMBL:AIT00720.1,
RC   ECO:0000313|Proteomes:UP000029666};
RX   PubMed=25267672;
RA   Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S.,
RA   Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A.,
RA   Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W.,
RA   Donnelly P., Thorson S., Amatya P., Joshi S.;
RT   "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella
RT   pneumoniae Isolates from Neonatal Infections in a Nepali Hospital
RT   Characterizes the Extent of Community- versus Hospital-Associated
RT   Transmission in an Endemic Setting.";
RL   Antimicrob. Agents Chemother. 58:7347-7357(2014).
RN   [2] {ECO:0000313|EMBL:CDO16225.1, ECO:0000313|Proteomes:UP000032739}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIP 52.145 {ECO:0000313|Proteomes:UP000032739}, and Kp52.145
RC   {ECO:0000313|EMBL:CDO16225.1};
RX   PubMed=25341126; DOI=10.3201/eid2011.140206;
RA   Bialek-Davenet S., Criscuolo A., Ailloud F., Passet V., Jones L.,
RA   Delannoy-Vieillard A.S., Garin B., Le Hello S., Arlet G.,
RA   Nicolas-Chanoine M.H., Decr D., Brisse S.;
RT   "Genomic Definition of Hypervirulent and Multidrug-Resistant
RT   Klebsiella pneumoniae Clonal Groups.";
RL   Emerg. Infect. Dis. 20:1812-1820(2014).
RN   [3] {ECO:0000313|EMBL:KMW82807.1, ECO:0000313|Proteomes:UP000037134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGH83 {ECO:0000313|EMBL:KMW82807.1,
RC   ECO:0000313|Proteomes:UP000037134};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S.,
RA   Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V.,
RA   Gombosev A., Delaney M., Dubois A., Ernst C., Kim D.S., Rossman W.,
RA   Gohs F., Petruso H., Nozar T., Mougeot F., Manson-Mcguire A.,
RA   Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M.,
RA   Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000067608}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608};
RA   Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G.,
RA   Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.;
RT   "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae
RT   strain CAV1193.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ALR25710.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CAV1193 {ECO:0000313|EMBL:ALR25710.1};
RX   PubMed=26823590;
RA   Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G.,
RA   Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.;
RT   "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae
RT   Strain CAV1193.";
RL   Genome Announc. 4:e01649-15(2016).
RN   [6] {ECO:0000313|EMBL:SBY72087.1, ECO:0000313|Proteomes:UP000092856}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB463 {ECO:0000313|EMBL:SBY72087.1,
RC   ECO:0000313|Proteomes:UP000092856};
RG   Pathogen Informatics;
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:ARA46573.1, ECO:0000313|Proteomes:UP000190083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR_0068 {ECO:0000313|EMBL:ARA46573.1,
RC   ECO:0000313|Proteomes:UP000190083};
RA   Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.;
RT   "Whole genome sequencing of Klebsiella pneumoniae AR_0068.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:SLP40627.1, ECO:0000313|Proteomes:UP000191867, ECO:0000313|Proteomes:UP000191942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VRCO0168 {ECO:0000313|EMBL:SLY46488.1,
RC   ECO:0000313|Proteomes:UP000191942}, and VRES0139
RC   {ECO:0000313|EMBL:SLP40627.1, ECO:0000313|Proteomes:UP000191867};
RG   Pathogen Informatics;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ARM24278.1, ECO:0000313|Proteomes:UP000193429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K66-45 {ECO:0000313|EMBL:ARM24278.1,
RC   ECO:0000313|Proteomes:UP000193429};
RA   Heikal A., Samuelsen O., Kristensen T., Rongved P., Okstad O.A.;
RT   "Complete Genome Sequence of a Multi-Drug Resistant, blaNDM-1-
RT   expressing Klebsiella pneumoniae Clinical Isolate from Norway.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of
CC       aminoacyl-tRNA to the A-site of ribosomes during protein
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00118}.
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DR   EMBL; CP008929; AIT00720.1; -; Genomic_DNA.
DR   EMBL; CP008929; AIT01316.1; -; Genomic_DNA.
DR   EMBL; CP013322; ALR25102.1; -; Genomic_DNA.
DR   EMBL; CP013322; ALR25710.1; -; Genomic_DNA.
DR   EMBL; CP020067; ARA46573.1; -; Genomic_DNA.
DR   EMBL; CP020067; ARA47218.1; -; Genomic_DNA.
DR   EMBL; CP020901; ARM24278.1; -; Genomic_DNA.
DR   EMBL; CP020901; ARM24877.1; -; Genomic_DNA.
DR   EMBL; FO834906; CDO16225.1; -; Genomic_DNA.
DR   EMBL; LGJJ01000014; KMW82807.1; -; Genomic_DNA.
DR   EMBL; LGJJ01000012; KMW85930.1; -; Genomic_DNA.
DR   EMBL; FLXG01000026; SBY72087.1; -; Genomic_DNA.
DR   EMBL; FWHC01000020; SLP40627.1; -; Genomic_DNA.
DR   EMBL; FWNZ01000036; SLY46488.1; -; Genomic_DNA.
DR   RefSeq; WP_004174069.1; NZ_NCSD01000003.1.
DR   EnsemblBacteria; AIT00720; AIT00720; PMK1_01228.
DR   EnsemblBacteria; AIT01316; AIT01316; PMK1_01841.
DR   EnsemblBacteria; ALR25102; ALR25102; AGG09_12930.
DR   EnsemblBacteria; ALR25710; ALR25710; AGG09_16220.
DR   EnsemblBacteria; CDO16225; CDO16225; BN49_4482.
DR   EnsemblBacteria; SBY72087; SBY72087; SAMEA3531848_05140.
DR   KEGG; kpb:FH42_14950; -.
DR   KEGG; kpb:FH42_18150; -.
DR   KEGG; kpne:KU54_002020; -.
DR   KEGG; kpne:KU54_025635; -.
DR   KEGG; kpnu:LI86_02015; -.
DR   KEGG; kpnu:LI86_25475; -.
DR   KEGG; kpx:PMK1_01228; -.
DR   KEGG; kpx:PMK1_01841; -.
DR   PATRIC; fig|573.1352.peg.3071; -.
DR   eggNOG; ENOG4105CGV; Bacteria.
DR   eggNOG; COG0050; LUCA.
DR   KO; K02358; -.
DR   Proteomes; UP000029666; Chromosome.
DR   Proteomes; UP000032739; Chromosome.
DR   Proteomes; UP000037134; Unassembled WGS sequence.
DR   Proteomes; UP000067608; Chromosome.
DR   Proteomes; UP000092856; Unassembled WGS sequence.
DR   Proteomes; UP000190083; Chromosome.
DR   Proteomes; UP000191867; Unassembled WGS sequence.
DR   Proteomes; UP000191942; Unassembled WGS sequence.
DR   Proteomes; UP000193429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-HAMAP.
DR   CDD; cd03697; EFTU_II; 1.
DR   HAMAP; MF_00118_B; EF_Tu_B; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00485; EF-Tu; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029666,
KW   ECO:0000313|Proteomes:UP000032739, ECO:0000313|Proteomes:UP000037134,
KW   ECO:0000313|Proteomes:UP000067608};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Elongation factor {ECO:0000256|HAMAP-Rule:MF_00118,
KW   ECO:0000313|EMBL:ALR25710.1};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Hydrolase {ECO:0000313|EMBL:ALR25710.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00118};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00118}.
FT   DOMAIN       10    204       Tr-type G (guanine nucleotide-binding).
FT                                {ECO:0000259|PROSITE:PS51722}.
FT   NP_BIND      19     26       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
FT   NP_BIND      81     85       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
FT   NP_BIND     136    139       GTP. {ECO:0000256|HAMAP-Rule:MF_00118}.
SQ   SEQUENCE   394 AA;  43246 MW;  DBA4133541205DD8 CRC64;
     MSKEKFERTK PHVNVGTIGH VDHGKTTLTA AITTVLAKTY GGSARAFDQI DNAPEEKARG
     ITINTSHVEY DTPTRHYAHV DCPGHADYVK NMITGAAQMD GAILVVAATD GPMPQTREHI
     LLGRQVGVPY IIVFLNKCDM VDDEELLELV EMEVRELLSQ YDFPGDDTPI VRGSALKALE
     GDAEWEAKII ELAGHLDTYI PEPERAIDKP FLLPIEDVFS ISGRGTVVTG RVERGIIKVG
     EEVEIVGIKE TAKTTCTGVE MFRKLLDEGR AGENVGVLLR GIKREEIERG QVLAKPGTIN
     PHTKFESEVY ILSKDEGGRH TPFFKGYRPQ FYFRTTDVTG TIELPEGVEM VMPGDNIKMV
     VTLIHPIAMD DGLRFAIREG GRTVGAGVVA KVLG
//
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