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Database: UniProt/TrEMBL
Entry: A0A0N8EU87_HETGA
LinkDB: A0A0N8EU87_HETGA
Original site: A0A0N8EU87_HETGA 
ID   A0A0N8EU87_HETGA        Unreviewed;       691 AA.
AC   A0A0N8EU87;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 8.
DE   SubName: Full=Protein-glutamine gamma-glutamyltransferase 2 isoform a {ECO:0000313|EMBL:JAO01366.1};
GN   Name=TGM2 {ECO:0000313|EMBL:JAO01366.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:JAO01366.1};
RN   [1] {ECO:0000313|EMBL:JAO01366.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:JAO01366.1};
RA   Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA   Platzer M., Szafranski K.;
RT   "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GEBF01002267; JAO01366.1; -; Transcribed_RNA.
DR   RefSeq; XP_004867843.1; XM_004867786.1.
DR   Ensembl; ENSHGLT00000007470; ENSHGLP00000007385; ENSHGLG00000005377.
DR   GeneID; 101699097; -.
DR   KEGG; hgl:101699097; -.
DR   CTD; 7052; -.
DR   KO; K05625; -.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
DR   GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0060662; P:salivary gland cavitation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:JAO01366.1}.
FT   DOMAIN      269    361       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    277    277       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    335    335       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    358    358       {ECO:0000256|PIRSR:PIRSR000459-1}.
SQ   SEQUENCE   691 AA;  77438 MW;  EDF4615354CA6134 CRC64;
     MAEDLVLERC DLQLEVNGRD HRTADLCRER LVLRRGQPFW LTLHFEGRGY EASVDTLTFS
     AVTGPAPSEE AGTKARFSLS DAVDGCAWSA SAVDQQDGVL SLLLNTPADA PIGLYRLSLE
     ASTGYQGSSF VLGHFTLLFN AWCPADTVYV DSDQERQEYV LTQQGFIYQG SAKFIKSTPW
     NFGQFEDGIL DICLILLDVN PKFLKDAGRD CSRRRSPIYV GRVVSAMVNC NDDQGVLLGR
     WDNNYGDGIS PMSWIGSVEI LRRWKDYGCQ RVKYGQCWVF AAVACTVLRC LGVPTRVVTN
     YNSAHDQNSN LLIEYFRNES GETEGNKSEM IWNFHCWVES WMTRPDLEPG YEGWQALDPT
     PQEKSEGTYC CGPVPVRAIK EGNLSIKYDA PFVFAEVNAD VVDWIRQEDG SLHKSINHSL
     VVGLKISTKS VGRDEREDIT HTYKYPEGSE EEREAFTRAN HLNKLAEKEE VKEEAQVDMR
     IRVGQNMNMG SDFDVFAHIN NSTAESRDCR LLLCARTVSY NGVLGPECGT KDLPDLTLDP
     FSERSIPLHI LYEKYSDYLT ECNLIKVRGL LIEPAANSYV LAERDLYLEN PEVKIRVLGE
     PKQNRKLVAE VSLKNPLPVP LLGCIFTVEG AGLTKEQKSV EVPGPVESGE QVKVRVDLLP
     TDVGLHKLVV NFECDRLKAV KGYRNVIIGP P
//
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