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Database: UniProt/TrEMBL
Entry: A0A0P6J508_HETGA
LinkDB: A0A0P6J508_HETGA
Original site: A0A0P6J508_HETGA 
ID   A0A0P6J508_HETGA        Unreviewed;       638 AA.
AC   A0A0P6J508;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   SubName: Full=Neuroendocrine convertase 2 isoform 3 {ECO:0000313|EMBL:JAN99411.1};
GN   Name=PCSK2 {ECO:0000313|EMBL:JAN99411.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:JAN99411.1};
RN   [1] {ECO:0000313|EMBL:JAN99411.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:JAN99411.1};
RA   Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA   Platzer M., Szafranski K.;
RT   "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
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DR   EMBL; GEBF01004221; JAN99411.1; -; Transcribed_RNA.
DR   RefSeq; XP_004840907.1; XM_004840850.2.
DR   Ensembl; ENSHGLT00000013983; ENSHGLP00000013842; ENSHGLG00000009894.
DR   Ensembl; ENSHGLT00100008621; ENSHGLP00100008520; ENSHGLG00100006349.
DR   GeneID; 101710029; -.
DR   KEGG; hgl:101710029; -.
DR   CTD; 5126; -.
DR   KO; K01360; -.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0034230; P:enkephalin processing; IEA:Ensembl.
DR   GO; GO:0030070; P:insulin processing; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR002884; PrprotnconvertsP.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912743};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912730};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912691}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    638       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006128587.
FT   DOMAIN       33    109       S8_pro-domain. {ECO:0000259|Pfam:
FT                                PF16470}.
FT   DOMAIN      158    420       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      504    590       P_proprotein. {ECO:0000259|Pfam:PF01483}.
SQ   SEQUENCE   638 AA;  70522 MW;  754104642B801A8E CRC64;
     MKGACGSRWQ AAAGLLFCVM VSASAERPIF TNHFLVELHK GGEEEARQVA GEHGFGVRKL
     PFMEGLYHFY HNGLTKAKRR RSLQHKQQLE RDPRVKMALQ QEGFNRKKRG YRDINEIDIN
     MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN
     YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM
     LDQPFMTDVI EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
     GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK
     RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NMGLTWRDMQ HLTVLTSKRN
     QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GTVQDPEKIP
     PTGKLVLTLT TAACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP
     RDDDSKVGFD KWPFMTTHTW GEDARGTWML ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
     DQVVRDYQSK LAMSKKQELE EELDEAVERS LKSILGKN
//
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