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Database: UniProt/TrEMBL
Entry: A0A0S2UQ43_SHEEP
LinkDB: A0A0S2UQ43_SHEEP
Original site: A0A0S2UQ43_SHEEP 
ID   A0A0S2UQ43_SHEEP        Unreviewed;       911 AA.
AC   A0A0S2UQ43;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|EMBL:ALP73373.1};
RN   [1] {ECO:0000313|EMBL:ALP73373.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hoefler B.C., Straight P.D.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KT180155; ALP73373.1; -; mRNA.
DR   RefSeq; NP_001305004.1; NM_001318075.1.
DR   RefSeq; XP_004012285.1; XM_004012236.3.
DR   RefSeq; XP_012040330.1; XM_012184940.2.
DR   RefSeq; XP_012040331.1; XM_012184941.2.
DR   RefSeq; XP_012040332.1; XM_012184942.1.
DR   RefSeq; XP_012040333.1; XM_012184943.2.
DR   RefSeq; XP_012040334.1; XM_012184944.2.
DR   RefSeq; XP_012040335.1; XM_012184945.2.
DR   RefSeq; XP_012040336.1; XM_012184946.1.
DR   RefSeq; XP_012040337.1; XM_012184947.2.
DR   RefSeq; XP_014953750.1; XM_015098264.1.
DR   RefSeq; XP_014953751.1; XM_015098265.1.
DR   GeneID; 101116239; -.
DR   KEGG; oas:101116239; -.
DR   CTD; 3981; -.
DR   KO; K10777; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      355    489       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      654    743       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      845    911       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   911 AA;  103905 MW;  EE5CCC0C5F5D043E CRC64;
     MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFK AFLDSWRKFH DALHKNQKDV
     TDSFYPAMRL ILPQLERERM AYGIKEIMLA KLYVELLNLP RDGKDALKLL NYRTPTGTRG
     DAGDFAMIAY FVLKPRCLQK GSLSIQQVND ILDSIASNNS AKRKDLMKKS VLQLITQSSA
     LEQKWLIRMI VKDLKLGFSQ HTVFSVFHRD AAELHNVTTD LEKVCRQLHD PSVGLSDISI
     TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYRY FSRNGYNYED
     QFGASPQEGS LTPFIHNAFR TDVLNCILDG EMMAYNPNTQ TFMQKGNKFD IKRMVEDSEL
     QTCYCVFDVL MVNDKKLGHE TLRKRFEILN SVFTPVPGRI EIVQKTQAHT KKEVIDALNE
     AIDKREEGIM VKHPLSIYKP DKRGEGWLKI KPEYVSGLMD ELDILIVGGY WGKGARGGMM
     SHFLCAVAEK PASGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKAFH RKAPPSNILC
     GTEKPEVYIE PCNSVIVQVK ATEIVPSDMY KTGCTLRFPR IEKIREDKEW YECTSLEDLE
     QLRGKACGKL ASKHLYMSGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLS NVNRVSTVFE
     DVEFCVMSGT SNHPKPDLEN RIAELGGYVV QNPGPDTYCV IAGSDNIRVK NIISSDKHDV
     VKPEWLLECF RTRSCVPWQP RFMIHMCPST KQHFAQEYDQ FGDSYFVDTD LHRLKEVFSG
     IKNAGEQTPG EMSPVIADLE HRYSWASMPL SMFRHHTVYL DLYAVINDLS TRIKGARLAI
     TALELRFHGA QVVSCLAEGV SHVIVGEDQS RVADLKAIRR TLKRKFKILQ ERWVTVSIDK
     CELQEENQYL V
//
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