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Database: UniProt/TrEMBL
Entry: A0A0U2XML3_9MICC
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ID   A0A0U2XML3_9MICC        Unreviewed;       740 AA.
AC   A0A0U2XML3;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   07-JUN-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:ALU39522.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ALU39522.1};
GN   ORFNames=AS188_06870 {ECO:0000313|EMBL:ALU39522.1};
OS   Kocuria flava.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=446860 {ECO:0000313|EMBL:ALU39522.1, ECO:0000313|Proteomes:UP000057181};
RN   [1] {ECO:0000313|EMBL:ALU39522.1, ECO:0000313|Proteomes:UP000057181}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HO-9041 {ECO:0000313|EMBL:ALU39522.1,
RC   ECO:0000313|Proteomes:UP000057181};
RA   Zhou M., Dai J.;
RT   "Complete Genome Sequence of Kocuria flava strain HO-9041.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP013254; ALU39522.1; -; Genomic_DNA.
DR   RefSeq; WP_058858231.1; NZ_CP013254.1.
DR   EnsemblBacteria; ALU39522; ALU39522; AS188_06870.
DR   KEGG; kfv:AS188_06870; -.
DR   KO; K00031; -.
DR   Proteomes; UP000057181; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000057181};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ALU39522.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000057181}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  80006 MW;  B608A888B93EBA99 CRC64;
     MAKIIYTRTD EAPLLATYSF KPVVEAFAST AGVEVETRDI SLAGRIVAAF SDRLPEDQRM
     ADALAELGEL AKTPEANIIK LPNISASVPQ LKAAVKELQG QGFDLPDYPD EPGTDEEKEV
     RARYDKIKGS AVNPVLREGN SDRRAPASVK NYARKNPHRM GEWSADSRTN VATMGADDFR
     ANEQSVVVAE DGALSIRLVA EDGSTTVLKE SVPVLAGEVV DSTVMRAAAL DAFLAEQVER
     AKREDVLFSV HLKATMMKVS DPIIFGHVIE AFFPELFAAH GEALREAGLS PDNGLAAILN
     GLDDLPAGVR DEVRAAVDKG LAEGPKLAMV NSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEAD TLAVLPDSSY AGVYQVVIDD CRRNGAFDPR TMGSVPNVGL MAMKAEEYGS
     HDKTFEIPAA GRVQVVDGSG TVLMEHEVAA GDIWRACQTK DVAVRDWVKL AVTRARATGS
     PAVFWLDRGR AHDANLIAKV EQYLGEHDTE GLQLEIMSPE EATAFSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLI NGGGLFETGA GGSAPKHVQQ LVEENHLRWD
     SLGEFLALAA SFDHLATRYD NARAQVLADT LDRATGTFLE ENKSPSRKAG EIDNRGSHFY
     LALYWAQELA RQDADAELAR AFAAVAQELA ENEQAINEEL LAVQGRPADI GGYYRPDDAK
     TTAVMRPSET FNRVLASLSA
//
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