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Database: UniProt/TrEMBL
Entry: A0A0U3KDR6_STRGL
LinkDB: A0A0U3KDR6_STRGL
Original site: A0A0U3KDR6_STRGL 
ID   A0A0U3KDR6_STRGL        Unreviewed;       740 AA.
AC   A0A0U3KDR6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   07-JUN-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:ALU97053.1};
GN   ORFNames=WQO_29195 {ECO:0000313|EMBL:ALU97053.1};
OS   Streptomyces globisporus C-1027.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1172567 {ECO:0000313|EMBL:ALU97053.1};
RN   [1] {ECO:0000313|EMBL:ALU97053.1, ECO:0000313|Proteomes:UP000064183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C-1027 {ECO:0000313|EMBL:ALU97053.1,
RC   ECO:0000313|Proteomes:UP000064183};
RX   PubMed=22815456; DOI=10.1128/JB.00797-12;
RA   Wang L., Wang S., He Q., Yu T., Li Q., Hong B.;
RT   "Draft genome sequence of Streptomyces globisporus C-1027, which
RT   produces an antitumor antibiotic consisting of a nine-membered
RT   enediyne with a chromoprotein.";
RL   J. Bacteriol. 194:4144-4144(2012).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP013738; ALU97053.1; -; Genomic_DNA.
DR   RefSeq; WP_010064040.1; NZ_CP013738.1.
DR   EnsemblBacteria; ALU97053; ALU97053; WQO_29195.
DR   KEGG; sgb:WQO_29195; -.
DR   KO; K00031; -.
DR   Proteomes; UP000064183; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000064183};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       349    349       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     546    546       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        419    419       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  79007 MW;  6C39CEE011F82482 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVEAYA STAGVTVERR DISLAGRIIA SFPEHLKAEQ
     RIDDALAELG ELARTPGANI IKLPNISASI PQLKAAIAEL QEQGYALPDY PDDPRTDAEK
     DVRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWTADSK TNVATMGVDD
     FRSTEKSAVV AEDGTLRIEL HGDDGTTTVL RESVPVLKGE VVDAAVMRVA ALREFFTAQV
     ARAKAEGVLF SLHLKATMMK VSDPIIFGHA VRAFFPNTFA KYGDQLAAAG LTPNDGLGGI
     LKGLGSLPDV GAEIQASFEA ELAEGPALAM VDSDKGITNL HVPSDVIVDA SMPAMIRTSG
     HMWGPDGNEA DTIAVLPDSS YAGVYQVVID DCRANGAFDP ATMGSVPNVG LMAQKAEEYG
     SHDKTFEIPA TGTVRVVDAS GAVVLEQAVG AGDIFRMCQT KDLPIQDWVK LAVTRARATG
     NPAVFWLDET RAHDANLIAK VTTYLADHDT DGLDISVKSP EEATAFSLER IRRGEDTISV
     TGNVLRDYLT DLFPILELGT SAKMLSVVPL MNGGGLFETG AGGSAPKHVQ QLVKENYLRW
     DSLGEFLALA VSFEHLATTT DNARAQVLAD TLDRATGTFL NEDKSPSRRL GGIDNRGSHF
     YLALYWAQEL AQQTDDAKLA EAFAPLAKTL AEQEETIVAE LVAVQGSPAE IGGYFQPDPA
     KAAAVMRPSA TFNNAIASLA
//
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