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Database: UniProt/TrEMBL
Entry: A0A0U4AIH6_9DEIO
LinkDB: A0A0U4AIH6_9DEIO
Original site: A0A0U4AIH6_9DEIO 
ID   A0A0U4AIH6_9DEIO        Unreviewed;       330 AA.
AC   A0A0U4AIH6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
DE            EC=1.1.1.37 {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
GN   Name=mdh {ECO:0000256|HAMAP-Rule:MF_01517};
GN   ORFNames=AUC44_03110 {ECO:0000313|EMBL:ALW88012.1};
OS   Deinococcus actinosclerus.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales;
OC   Deinococcaceae; Deinococcus.
OX   NCBI_TaxID=1768108 {ECO:0000313|EMBL:ALW88012.1};
RN   [1] {ECO:0000313|EMBL:ALW88012.1, ECO:0000313|Proteomes:UP000060071}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BM2 {ECO:0000313|EMBL:ALW88012.1,
RC   ECO:0000313|Proteomes:UP000060071};
RA   Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate. {ECO:0000256|HAMAP-Rule:MF_01517,
CC       ECO:0000256|SAAS:SAAS00755561}.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369698}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01517}.
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DR   EMBL; CP013910; ALW88012.1; -; Genomic_DNA.
DR   RefSeq; WP_062157353.1; NZ_CP013910.1.
DR   EnsemblBacteria; ALW88012; ALW88012; AUC44_03110.
DR   KEGG; dab:AUC44_03110; -.
DR   KO; K00024; -.
DR   Proteomes; UP000060071; Chromosome.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.110.10; -; 1.
DR   HAMAP; MF_01517; Malate_dehydrog_2; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000060071};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01517};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU003369};
KW   Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   DOMAIN        7    148       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      159    323       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   NP_BIND      13     19       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   NP_BIND     131    133       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   ACT_SITE    189    189       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517, ECO:0000256|PIRSR:PIRSR000102-
FT                                1}.
FT   BINDING      94     94       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     100    100       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     107    107       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     114    114       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     133    133       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     164    164       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
SQ   SEQUENCE   330 AA;  35296 MW;  6AFA718713DDA129 CRC64;
     MTTKQPVRVA VTGAAGQIGY SLLFRIASGD MLGKDQPVIL QLLEITPALK ALNGVVMELR
     DCAFPLLADI VTSDDPMVAF KDADYALLVG AMPRKAGMER GDLLGANGGI FKPQGEALNA
     VASRDVKVLV VGNPANTNAL IAQQNAPDLD PKQFTAMVRL DHNRAISQLA EKTGKPVSSI
     KNLTIWGNHS STQYPDLSQA TVDGQPALDQ VDRDWYEQQY ISTVAKRGAA IIEARGLSSA
     ASAASAAIDH MRDWALGTPE GEWVSMGIPS DGSYGIPEGL IYGFPVTCKD GQYEIVQGLP
     VSNFSRGKMD ATAQELTEER DEVRKLGLVK
//
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