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Database: UniProt/TrEMBL
Entry: A0A0X4JWT3_9MICC
LinkDB: A0A0X4JWT3_9MICC
Original site: A0A0X4JWT3_9MICC 
ID   A0A0X4JWT3_9MICC        Unreviewed;       739 AA.
AC   A0A0X4JWT3;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUL-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:KUR65367.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:KUR65367.1};
GN   ORFNames=JM67_05890 {ECO:0000313|EMBL:KUR65367.1};
OS   Arthrobacter sp. ATCC 21022.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=1771959 {ECO:0000313|EMBL:KUR65367.1};
RN   [1] {ECO:0000313|EMBL:KUR65367.1, ECO:0000313|Proteomes:UP000067723}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KY 3901 {ECO:0000313|EMBL:KUR65367.1,
RC   ECO:0000313|Proteomes:UP000067723};
RA   Edwards T.;
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUR65367.1}.
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DR   EMBL; JPWK01000016; KUR65367.1; -; Genomic_DNA.
DR   RefSeq; WP_062095630.1; NZ_JPWK01000016.1.
DR   EnsemblBacteria; KUR65367; KUR65367; JM67_05890.
DR   GeneID; 32620285; -.
DR   KEGG; arz:AUT26_05290; -.
DR   PATRIC; fig|1532907.3.peg.3484; -.
DR   KO; K00031; -.
DR   Proteomes; UP000067723; Unassembled WGS sequence.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000067723};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:KUR65367.1}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79660 MW;  9ACF3DBFC0E950E5 CRC64;
     MAKIIYTHTD EAPMLATYSF LPIVEAYAST AGVEVETRDI SLAGRIIAVF GDFLTEEQRT
     GNALAELGEL AKQPEANIIK LPNISASVPQ LKAAIAELQA QGYALPDYPD NPSSDTETDI
     RSRYDKIKGS AVNPVLREGN SDRRAPLSVK NYARQNPHSM GAWTADSKTN VATMGQNDFR
     SNEKSVVIEA DDALSIQLVR EDGSVKVLKK DFPVLAGEVV DGTVLRAEAL DEFLKAQVAR
     AKEEGILFSA HLKATMMKVS DPIIFGHVVK AYFSELFDTY GKQLAAAGIN PNNGLAAILN
     GLDELPEDVR EGVKTAITKG LEEGPALAMV DSDKGITSLH VPSDIIVDAS MPAMIRSSGH
     MWGPDGKEAD TLAVLPDSSY AGVYQVVIDD CRANGAFDPT TMGTVPNVGL MAQAAEEYGS
     HDKTFEIEAA GTVQLVNRAG TVLIEHQVSP GDIWRACQTK DVPIRDWVKL AVTRARASET
     PAVFWLDKGR AHDANLIAKV NEYLKDHDTE GLQIEILSPE EATAFTLERI RKGQDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSIVPLI NGGGLFETGA GGSAPKHVQQ LVKENHLRWD
     SLGEFLALAV SFEHLATTTG NARAQVLADT LDRATGTFLL ENKSPRRSVG ELDNRGSHFY
     LAMYWAQELA KQSSDAELAA AFAPIAEELT SNEDAIVGEL NAVQGPAVDL GGYYRPDAAK
     AAEVMRPSAT FNKVLATLK
//
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