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Database: UniProt/TrEMBL
Entry: A0A109SQX0_9MYCO
LinkDB: A0A109SQX0_9MYCO
Original site: A0A109SQX0_9MYCO 
ID   A0A109SQX0_9MYCO        Unreviewed;       497 AA.
AC   A0A109SQX0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=RN08_3373 {ECO:0000313|EMBL:AMC60800.1};
OS   Mycobacterium microti.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1806 {ECO:0000313|EMBL:AMC60800.1};
RN   [1] {ECO:0000313|EMBL:AMC60800.1, ECO:0000313|Proteomes:UP000065169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12 {ECO:0000313|EMBL:AMC60800.1,
RC   ECO:0000313|Proteomes:UP000065169};
RX   PubMed=26704977; DOI=10.1093/nar/gkv1498;
RA   Zhu L., Zhong J., Jia X., Liu G., Kang Y., Dong M., Zhang X., Li Q.,
RA   Yue L., Li C., Fu J., Xiao J., Yan J., Zhang B., Lei M., Chen S.,
RA   Lv L., Zhu B., Huang H., Chen F.;
RT   "Precision methylome characterization of Mycobacterium tuberculosis
RT   complex (MTBC) using PacBio single-molecule real-time (SMRT)
RT   technology.";
RL   Nucleic Acids Res. 44:730-743(2016).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CP010333; AMC60800.1; -; Genomic_DNA.
DR   EnsemblBacteria; AMC60800; AMC60800; RN08_3373.
DR   KEGG; mmic:RN08_3373; -.
DR   PATRIC; fig|1806.5.peg.3596; -.
DR   KO; K10747; -.
DR   Proteomes; UP000065169; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000065169};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:AMC60800.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      278    402       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
SQ   SEQUENCE   497 AA;  52645 MW;  26DAE1C6EF91B268 CRC64;
     MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE LPQRHIGVGW AALRSLPPPA
     PQPALTVTGV DATLSKIGTL SGKGSQAQRA ALVAELFSAA TEAEQTFLLR LLGGELRQGA
     KGGIMADAVA QAAGLPAATV QRAAMLGGDL AAAAAAGLSG AALDTFTLRV GRPIGPMLAQ
     TATSVHDALE RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL PEVVEATLAL
     PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF DILHRDGTDL
     LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT LAAGHEGVMA KAPAARYLAG
     RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR GKLSNIHLGA RDPATGGFVM VGKTFKGMTD
     AMLDWQTTRF HEIAVGPTDG YVVQLRPEQV VEVALDGVQR SSRYPGGLAL RFARVVRYRA
     DKDPAEADTI DAVRALY
//
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