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Database: UniProt/TrEMBL
Entry: A0A125U7J2_LACCD
LinkDB: A0A125U7J2_LACCD
Original site: A0A125U7J2_LACCD 
ID   A0A125U7J2_LACCD        Unreviewed;       196 AA.
AC   A0A125U7J2;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-SEP-2017, entry version 11.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=kitH {ECO:0000313|EMBL:AEA56850.1};
GN   Synonyms=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=LCBD_1353 {ECO:0000313|EMBL:AEA56850.1};
OS   Lactobacillus casei (strain BD-II).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=998820 {ECO:0000313|EMBL:AEA56850.1, ECO:0000313|Proteomes:UP000006850};
RN   [1] {ECO:0000313|EMBL:AEA56850.1, ECO:0000313|Proteomes:UP000006850}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BD-II {ECO:0000313|EMBL:AEA56850.1,
RC   ECO:0000313|Proteomes:UP000006850};
RX   PubMed=21478345; DOI=10.1128/JB.00421-11;
RA   Ai L., Chen C., Zhou F., Wang L., Zhang H., Chen W., Guo B.;
RT   "Complete genome sequence of the probiotic strain Lactobacillus casei
RT   BD-II.";
RL   J. Bacteriol. 193:3160-3161(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; CP002618; AEA56850.1; -; Genomic_DNA.
DR   RefSeq; WP_003564944.1; NC_017474.1.
DR   ProteinModelPortal; A0A125U7J2; -.
DR   EnsemblBacteria; AEA56850; AEA56850; LCBD_1353.
DR   GeneID; 31581805; -.
DR   KEGG; lcs:LCBD_1353; -.
DR   PATRIC; fig|998820.3.peg.1332; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   Proteomes; UP000006850; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006850};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:AEA56850.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND       9     16       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      85     88       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     86     86       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       143    143       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       146    146       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       180    180       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       183    183       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   196 AA;  22427 MW;  2AA4E69E19ACC6F9 CRC64;
     MAQLFFRYGA MNSGKSIEIL KVAHNYEEQN KRVILMTSAV DDRAGVGMIA SRIGLERTAI
     PITHETNLYD IIKATDPKAA CVLIDEAQFL QKHHIFEAAR VVDELHIPVM AFGLKNDFRN
     ELFEGSKYLL LYADKIEEMK TICWFCAKKA IMNLRIHDGQ PVYEGKQVLI GGNESYYPVC
     RHHYFHPPLK QIDPTD
//
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