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Database: UniProt/TrEMBL
Entry: A0A127MVC0_9PSED
LinkDB: A0A127MVC0_9PSED
Original site: A0A127MVC0_9PSED 
ID   A0A127MVC0_9PSED        Unreviewed;       740 AA.
AC   A0A127MVC0;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   07-JUN-2017, entry version 7.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:AMO77216.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AMO77216.1};
GN   Name=icd_2 {ECO:0000313|EMBL:AMO77216.1};
GN   ORFNames=PcP3B5_38040 {ECO:0000313|EMBL:AMO77216.1};
OS   Pseudomonas citronellolis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=53408 {ECO:0000313|EMBL:AMO77216.1, ECO:0000313|Proteomes:UP000072469};
RN   [1] {ECO:0000313|EMBL:AMO77216.1, ECO:0000313|Proteomes:UP000072469}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P3B5 {ECO:0000313|EMBL:AMO77216.1,
RC   ECO:0000313|Proteomes:UP000072469};
RA   Remus-Emsermann M.N.P., Schmid M., Gekenidis M.-T., Zbinden R.,
RA   Pelludat C., Frey J., Ahrens C.H.;
RT   "The full genome sequence of Pseudomonas citronellolis P3B5, an alkane
RT   degrading bacterium with considerable biochemical interest isolated
RT   from basil leaves.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP014158; AMO77216.1; -; Genomic_DNA.
DR   RefSeq; WP_009623237.1; NZ_LKKN01000068.1.
DR   EnsemblBacteria; AMO77216; AMO77216; PcP3B5_38040.
DR   KEGG; pcq:PcP3B5_38040; -.
DR   KO; K00031; -.
DR   Proteomes; UP000072469; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000072469};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AMO77216.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       349    349       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     546    546       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        254    254       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        419    419       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  81687 MW;  F5E12061A98D0C37 CRC64;
     MSNRSKITYT FTDEAPALAT YSLLPIVKAF AASADIDVET RDISLAGRIL AAFTDKLGDK
     AIEDDLAYLA KLATAPDANI IKLPNISASV PQLKGAIAEL QALGYAIPDF PEDPQTDEEK
     DTRARYAKVL GSAVNPVLRE GNSDRRAPAA VKAYARKHPH SMGKWSMASR SHADYMRGGD
     FFSSEQSVTI PKAGEVRIEF VGKDGKVELK KTLKMQEGEV LDSMFMSCNK LRAFFEKTLQ
     DCKETGVMWS LHVKATMMKI SHPIVFGHAV TVYYKDVFDK WGQLFDELGV NPNNGISSVY
     DKIKSLPASQ QEEILHDIHE VYSHRPEMAM VDSVKGITNL HIPSDVIVDA SMPAMIRNSG
     QMWGKDGKQK DTKAVMPEST YARIYQEMIN FCKTNGAFDP TTMGSVPNVG LMAQKAEEYG
     SHDKTFEMEA DGTMRVVDED GKVLMQHEVE AGDIWRACQT KDAPIRDWVK LAVTRARQSN
     TPAIFWLDPE RAHDNELRKK VELYLKDHDL TGLDISIKGY NEAIRTSMER MIRGQDTISV
     TGNVLRDYLT DLFPIMELGT SAKMLSIVPL MAGGGMYETG AGGSAPKHVQ QLVEENYLRW
     DSLGEFLALA VSLEEEGIKT GNAKAKVLGK TLDEATGKLL DNNKSPARKV GEIDNRGSHF
     YLALYWAQAL AAQNEDAELK AHFTPLAKTL TEQEATIVAE LNGAQGKAVD IGGYYRSNPE
     KTSQVMRPSA TFNAAIDSLN
//
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