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Database: UniProt/TrEMBL
Entry: A0A133LKN2_BIFLN
LinkDB: A0A133LKN2_BIFLN
Original site: A0A133LKN2_BIFLN 
ID   A0A133LKN2_BIFLN        Unreviewed;       449 AA.
AC   A0A133LKN2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=Xylose isomerase {ECO:0000256|ARBA:ARBA00011958, ECO:0000256|HAMAP-Rule:MF_00455};
DE            EC=5.3.1.5 {ECO:0000256|ARBA:ARBA00011958, ECO:0000256|HAMAP-Rule:MF_00455};
GN   Name=xylA {ECO:0000256|HAMAP-Rule:MF_00455,
GN   ECO:0000313|EMBL:KAB6881665.1};
GN   ORFNames=APC1464_1430 {ECO:0000313|EMBL:PKD09801.1}, APC1476_1684
GN   {ECO:0000313|EMBL:PKC99121.1}, APC1503_1670
GN   {ECO:0000313|EMBL:PKC87756.1}, B5779_0036
GN   {ECO:0000313|EMBL:OQM72928.1}, B5U78_02545
GN   {ECO:0000313|EMBL:ROV52846.1}, DPC6316_1562
GN   {ECO:0000313|EMBL:PKC83739.1}, DPC6317_1585
GN   {ECO:0000313|EMBL:PKC82282.1}, DWV47_06195
GN   {ECO:0000313|EMBL:RGW83297.1}, DWZ73_05415
GN   {ECO:0000313|EMBL:RHM28565.1}, GBB40_08545
GN   {ECO:0000313|EMBL:KAB7394135.1}, GBB63_08640
GN   {ECO:0000313|EMBL:KAB7357719.1}, GBB65_00310
GN   {ECO:0000313|EMBL:KAB7323956.1}, GBB73_08895
GN   {ECO:0000313|EMBL:KAB7335808.1}, GBJ95_10495
GN   {ECO:0000313|EMBL:KAB6913618.1}, GBJ98_10930
GN   {ECO:0000313|EMBL:KAB6910046.1}, GBJ99_10695
GN   {ECO:0000313|EMBL:KAB6907670.1}, GBK03_10750
GN   {ECO:0000313|EMBL:KAB6894359.1}, GBK06_10705
GN   {ECO:0000313|EMBL:KAB6915738.1}, GBK07_10720
GN   {ECO:0000313|EMBL:KAB6881665.1}, GS08_08350
GN   {ECO:0000313|EMBL:AIF91112.1}, GT999_05760
GN   {ECO:0000313|EMBL:MZR88812.1}, GUA24_06090
GN   {ECO:0000313|EMBL:MZU08596.1}, HMPREF3231_01083
GN   {ECO:0000313|EMBL:KWZ92156.1}, SAMN04489748_0127
GN   {ECO:0000313|EMBL:SEB29245.1};
OS   Bifidobacterium longum.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=216816 {ECO:0000313|EMBL:KWZ92156.1, ECO:0000313|Proteomes:UP000070323};
RN   [1] {ECO:0000313|EMBL:AIF91112.1, ECO:0000313|Proteomes:UP000028505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BXY01 {ECO:0000313|EMBL:AIF91112.1,
RC   ECO:0000313|Proteomes:UP000028505};
RA   Zhao X.;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AIF91112.1, ECO:0000313|Proteomes:UP000028505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BXY01 {ECO:0000313|EMBL:AIF91112.1,
RC   ECO:0000313|Proteomes:UP000028505};
RA   Yuan J., Wei X., Li H., Liu W., Wang X.;
RT   "Bifidobacterium longum genome.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KWZ92156.1, ECO:0000313|Proteomes:UP000070323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMW7750 {ECO:0000313|EMBL:KWZ92156.1,
RC   ECO:0000313|Proteomes:UP000070323};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:SEB29245.1, ECO:0000313|Proteomes:UP000182842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20219 {ECO:0000313|EMBL:SEB29245.1,
RC   ECO:0000313|Proteomes:UP000182842};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OQM72928.1, ECO:0000313|Proteomes:UP000192607}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1886B {ECO:0000313|EMBL:OQM72928.1,
RC   ECO:0000313|Proteomes:UP000192607};
RA   Lugli G.A., Duranti S., Milani C., Mancabelli L.;
RT   "Maternal inheritance of bifidobacteria.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Proteomes:UP000232402, ECO:0000313|Proteomes:UP000232456}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APC1464 {ECO:0000313|EMBL:PKD09801.1,
RC   ECO:0000313|Proteomes:UP000232456}, APC1476
RC   {ECO:0000313|EMBL:PKC99121.1, ECO:0000313|Proteomes:UP000232402},
RC   APC1503 {ECO:0000313|EMBL:PKC87756.1,
RC   ECO:0000313|Proteomes:UP000232654}, DPC6316
RC   {ECO:0000313|EMBL:PKC83739.1, ECO:0000313|Proteomes:UP000232554}, and
RC   DPC6317 {ECO:0000313|EMBL:PKC82282.1,
RC   ECO:0000313|Proteomes:UP000232637};
RA   Arboleya S.;
RT   "Bifidobacterium longum APC/DPC strains.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000265840, ECO:0000313|Proteomes:UP000284732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF08-2 {ECO:0000313|EMBL:RGW83297.1,
RC   ECO:0000313|Proteomes:UP000284732}, and AF35-13AC
RC   {ECO:0000313|EMBL:RHM28565.1, ECO:0000313|Proteomes:UP000265840};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ROV52846.1, ECO:0000313|Proteomes:UP000273962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICIS-505 {ECO:0000313|EMBL:ROV52846.1,
RC   ECO:0000313|Proteomes:UP000273962};
RA   Andryuschenko S.V., Ivanova E.V., Perunova N.B., Semenovykh T.A.,
RA   Bukharin O.V.;
RT   "Draft genome sequence of some Bifidobacteria gut isolates.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|Proteomes:UP000429224, ECO:0000313|Proteomes:UP000430971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIOML-A280 {ECO:0000313|EMBL:KAB6913618.1,
RC   ECO:0000313|Proteomes:UP000474006}, BIOML-A283
RC   {ECO:0000313|EMBL:KAB6910046.1, ECO:0000313|Proteomes:UP000481350},
RC   BIOML-A284 {ECO:0000313|EMBL:KAB6915738.1,
RC   ECO:0000313|Proteomes:UP000491334}, BIOML-A286
RC   {ECO:0000313|EMBL:KAB6907670.1, ECO:0000313|Proteomes:UP000429224},
RC   BIOML-A290 {ECO:0000313|EMBL:KAB6894359.1,
RC   ECO:0000313|Proteomes:UP000473438}, BIOML-A294
RC   {ECO:0000313|EMBL:KAB6881665.1, ECO:0000313|Proteomes:UP000479642},
RC   BIOML-A37 {ECO:0000313|EMBL:KAB7394135.1,
RC   ECO:0000313|Proteomes:UP000468842}, BIOML-A395
RC   {ECO:0000313|EMBL:MZR88812.1, ECO:0000313|Proteomes:UP000466472},
RC   BIOML-A409 {ECO:0000313|EMBL:MZU08596.1}, BIOML-A55
RC   {ECO:0000313|EMBL:KAB7357719.1, ECO:0000313|Proteomes:UP000460881},
RC   BIOML-A65 {ECO:0000313|EMBL:KAB7335808.1,
RC   ECO:0000313|Proteomes:UP000430971}, and BIOML-A75
RC   {ECO:0000313|EMBL:KAB7323956.1, ECO:0000313|Proteomes:UP000451234};
RX   PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA   Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA   Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA   Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA   Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA   Xavier R.J., Alm E.J.;
RT   "A library of human gut bacterial isolates paired with longitudinal
RT   multiomics data enables mechanistic microbiome research.";
RL   Nat. Med. 25:1442-1452(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816,
CC         ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00033659, ECO:0000256|HAMAP-
CC         Rule:MF_00455, ECO:0000256|RuleBase:RU000609};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00455};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00455};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000610}.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005765, ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000609}.
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DR   EMBL; CP008885; AIF91112.1; -; Genomic_DNA.
DR   EMBL; WDZZ01000037; KAB6881665.1; -; Genomic_DNA.
DR   EMBL; WDZV01000039; KAB6894359.1; -; Genomic_DNA.
DR   EMBL; WDZR01000041; KAB6907670.1; -; Genomic_DNA.
DR   EMBL; WDZO01000047; KAB6910046.1; -; Genomic_DNA.
DR   EMBL; WDZL01000042; KAB6913618.1; -; Genomic_DNA.
DR   EMBL; WDZP01000045; KAB6915738.1; -; Genomic_DNA.
DR   EMBL; WDRV01000001; KAB7323956.1; -; Genomic_DNA.
DR   EMBL; WDRM01000024; KAB7335808.1; -; Genomic_DNA.
DR   EMBL; WDRC01000023; KAB7357719.1; -; Genomic_DNA.
DR   EMBL; WDQK01000020; KAB7394135.1; -; Genomic_DNA.
DR   EMBL; LRPQ01000056; KWZ92156.1; -; Genomic_DNA.
DR   EMBL; WXEF01000010; MZR88812.1; -; Genomic_DNA.
DR   EMBL; WXDR01000009; MZU08596.1; -; Genomic_DNA.
DR   EMBL; NAQL01000001; OQM72928.1; -; Genomic_DNA.
DR   EMBL; PJDQ01000011; PKC82282.1; -; Genomic_DNA.
DR   EMBL; PJDR01000017; PKC83739.1; -; Genomic_DNA.
DR   EMBL; PJDT01000023; PKC87756.1; -; Genomic_DNA.
DR   EMBL; PJDY01000019; PKC99121.1; -; Genomic_DNA.
DR   EMBL; PJEE01000011; PKD09801.1; -; Genomic_DNA.
DR   EMBL; QSAY01000003; RGW83297.1; -; Genomic_DNA.
DR   EMBL; QRPR01000003; RHM28565.1; -; Genomic_DNA.
DR   EMBL; RJZF01000002; ROV52846.1; -; Genomic_DNA.
DR   EMBL; FNRW01000001; SEB29245.1; -; Genomic_DNA.
DR   RefSeq; WP_007055684.1; NZ_WQQG01000005.1.
DR   GeneID; 69578773; -.
DR   KEGG; blx:GS08_08350; -.
DR   PATRIC; fig|216816.111.peg.1698; -.
DR   OMA; TLAMYEI; -.
DR   Proteomes; UP000028505; Chromosome.
DR   Proteomes; UP000070323; Unassembled WGS sequence.
DR   Proteomes; UP000182842; Unassembled WGS sequence.
DR   Proteomes; UP000192607; Unassembled WGS sequence.
DR   Proteomes; UP000232402; Unassembled WGS sequence.
DR   Proteomes; UP000232456; Unassembled WGS sequence.
DR   Proteomes; UP000232554; Unassembled WGS sequence.
DR   Proteomes; UP000232637; Unassembled WGS sequence.
DR   Proteomes; UP000232654; Unassembled WGS sequence.
DR   Proteomes; UP000265840; Unassembled WGS sequence.
DR   Proteomes; UP000273962; Unassembled WGS sequence.
DR   Proteomes; UP000284732; Unassembled WGS sequence.
DR   Proteomes; UP000429224; Unassembled WGS sequence.
DR   Proteomes; UP000430971; Unassembled WGS sequence.
DR   Proteomes; UP000451234; Unassembled WGS sequence.
DR   Proteomes; UP000460881; Unassembled WGS sequence.
DR   Proteomes; UP000466472; Unassembled WGS sequence.
DR   Proteomes; UP000468842; Unassembled WGS sequence.
DR   Proteomes; UP000473438; Unassembled WGS sequence.
DR   Proteomes; UP000474006; Unassembled WGS sequence.
DR   Proteomes; UP000479642; Unassembled WGS sequence.
DR   Proteomes; UP000481350; Unassembled WGS sequence.
DR   Proteomes; UP000491334; Unassembled WGS sequence.
DR   Proteomes; UP000638311; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR   HAMAP; MF_00455; Xylose_isom_A; 1.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR013452; Xylose_isom_bac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   NCBIfam; TIGR02630; xylose_isom_A; 1.
DR   PANTHER; PTHR48306; XYLOSE ISOMERASE; 1.
DR   PANTHER; PTHR48306:SF1; XYLOSE ISOMERASE; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   SUPFAM; SSF51658; Xylose isomerase-like; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW   Rule:MF_00455};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00455};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00455};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00455};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00455};
KW   Xylose metabolism {ECO:0000256|ARBA:ARBA00022629, ECO:0000256|HAMAP-
KW   Rule:MF_00455}.
FT   DOMAIN          90..286
FT                   /note="Xylose isomerase-like TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   ACT_SITE        101
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   ACT_SITE        104
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         232
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         268
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         268
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         271
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         296
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         307
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         309
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   BINDING         340
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
SQ   SEQUENCE   449 AA;  50854 MW;  A88BE0127601072D CRC64;
     MGLWDVDKIE YVGRAKGPKE DFAFHYYDAD KVVAGKKMKD WLRFGVAWWH TFNQELVDPF
     GTGTAHRPYY KYTDPMDQAL AKVDYAFELF QKLGVEYFCF HDRDIAPEGD TLRETNANLD
     KVVDKIDENM KSTGVKLLWN TSSLFTNPRF VSGAATSPFA DIYAYAGGQL KKSLEIGKRL
     GAENYVFWGG REGYENLWNT EMKRETDHIA KFFHMCADYA KEIGFEAQFL IEPKPKEPTL
     HQYDFDAATA IEFLRNHDLT DVFKLNLEGN HANLAGHTYQ HEIRVARESG FLGSLDANQG
     DKLIGWDMDE FPTDLYETVA VMWEVLQAGS IGPHGGLNFD AKPRRTSFYE EDLFRSHIAG
     MDAYAAGLLV ADKMNQDGFI QNLQAERYSS YDSGIGKDID EGNVTLADLE AYSLDKPQSE
     LIAATKSDHL ESVKATINNY IIDALAEVE
//
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