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Database: UniProt/TrEMBL
Entry: A0A133QQE7_STASI
LinkDB: A0A133QQE7_STASI
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ID   A0A133QQE7_STASI        Unreviewed;       199 AA.
AC   A0A133QQE7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   20-DEC-2017, entry version 11.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   ORFNames=CO689_02525 {ECO:0000313|EMBL:ATF29797.1}, HMPREF3215_01339
GN   {ECO:0000313|EMBL:KXA45013.1};
OS   Staphylococcus simulans.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1286 {ECO:0000313|EMBL:KXA45013.1};
RN   [1] {ECO:0000313|EMBL:KXA45013.1, ECO:0000313|Proteomes:UP000070135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MJR7712 {ECO:0000313|EMBL:KXA45013.1,
RC   ECO:0000313|Proteomes:UP000070135};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ATF29797.1, ECO:0000313|Proteomes:UP000218928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FDAARGOS_383 {ECO:0000313|EMBL:ATF29797.1,
RC   ECO:0000313|Proteomes:UP000218928};
RA   Goldberg B., Campos J., Tallon L., Sadzewicz L., Ott S., Zhao X.,
RA   Nagaraj S., Vavikolanu K., Aluvathingal J., Nadendla S., Geyer C.,
RA   Sichtig H.;
RT   "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT   Supporting development and validation of Infectious Disease Dx
RT   tests.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; CP023497; ATF29797.1; -; Genomic_DNA.
DR   EMBL; LRQJ01000017; KXA45013.1; -; Genomic_DNA.
DR   RefSeq; WP_002481799.1; NZ_LJSL01000018.1.
DR   EnsemblBacteria; KXA45013; KXA45013; HMPREF3215_01339.
DR   GeneID; 32049852; -.
DR   KEGG; ssif:AL483_01765; -.
DR   PATRIC; fig|1286.17.peg.1331; -.
DR   KO; K00857; -.
DR   Proteomes; UP000070135; Unassembled WGS sequence.
DR   Proteomes; UP000218928; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070135,
KW   ECO:0000313|Proteomes:UP000218928};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:KXA45013.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      15     22       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      88     91       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     89     89       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       145    145       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       148    148       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       183    183       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       186    186       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   199 AA;  22213 MW;  E01161B4AC8FCC9D CRC64;
     MYETYHSGWI ECITGSMFSG KSEELIRRLK RGMYAKQKVV VFKPAIDNRY HKEKVVSHNG
     NAIEAITIKA AEEIFEQDLT GVDVIGIDEV QFFEHSVVDI AQELAEQGHR VIVAGLDMDF
     RGEPFEPMPQ LMAVSELVTK LQAVCAVCGA PASRTQRLIN GRPAKADDPI IMVGADESYE
     PRCRAHHIVA PSETEKEEL
//
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