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Database: UniProt/TrEMBL
Entry: A0A143CAP4_9ACTN
LinkDB: A0A143CAP4_9ACTN
Original site: A0A143CAP4_9ACTN 
ID   A0A143CAP4_9ACTN        Unreviewed;       739 AA.
AC   A0A143CAP4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-SEP-2017, entry version 8.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AMW14299.1};
GN   ORFNames=A4E84_35295 {ECO:0000313|EMBL:AMW14299.1};
OS   Streptomyces sp. S10(2016).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1783515 {ECO:0000313|EMBL:AMW14299.1, ECO:0000313|Proteomes:UP000076096};
RN   [1] {ECO:0000313|EMBL:AMW14299.1, ECO:0000313|Proteomes:UP000076096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S10 {ECO:0000313|EMBL:AMW14299.1,
RC   ECO:0000313|Proteomes:UP000076096};
RA   Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K.,
RA   Barbian K., Babar A., Rosenke K.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP015098; AMW14299.1; -; Genomic_DNA.
DR   RefSeq; WP_062930442.1; NZ_CP015098.1.
DR   EnsemblBacteria; AMW14299; AMW14299; A4E84_35295.
DR   KEGG; stsi:A4E84_35295; -.
DR   KO; K00031; -.
DR   Proteomes; UP000076096; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000076096};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79294 MW;  CE662ADE8C52D876 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA VFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL QGQGYALPDY PDDPKTDEER
     EIRARYDKIK GSAVNPVLRE GNSDRRAPAS VKNYAKSHPH RMGAWTAESK TNVATMGQND
     FRSTEKSVVI AEDGALRIEL VGDDGTTTVL RESVPVLAGE VVDASVMRVA ALREFLTAQV
     AKAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA QYGDKLAAAG LTPNDGLGGI
     WKGLDSLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEHD TLAVLPDSSY AGVYQAVIDD CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEVPAT GTVRLVDGNG TALIEQAVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDETR AHDANLIAKV NTYLAEHDTE GLDIRILNPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SFEQLAKVAG NARAQVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA GQSDDADLAK AFAPLAETLA ANEQKIVDEL SAVQGKPVDI GGYYQPDPAK
     AAEAMRPSTT WNEALASLS
//
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