ID A0A168EM58_9MICO Unreviewed; 342 AA.
AC A0A168EM58;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013190};
DE EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
GN Name=adh_1 {ECO:0000313|EMBL:ANC30208.1};
GN ORFNames=I598_0628 {ECO:0000313|EMBL:ANC30208.1};
OS Isoptericola dokdonensis DS-3.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Promicromonosporaceae; Isoptericola.
OX NCBI_TaxID=1300344 {ECO:0000313|EMBL:ANC30208.1, ECO:0000313|Proteomes:UP000076794};
RN [1] {ECO:0000313|EMBL:ANC30208.1, ECO:0000313|Proteomes:UP000076794}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS-3 {ECO:0000313|EMBL:ANC30208.1,
RC ECO:0000313|Proteomes:UP000076794};
RA Kwon S.-K., Kim J.F.;
RT "Complete genome sequence of a soil Actinobacterium, Isoptericola
RT dokdonensis DS-3.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP014209; ANC30208.1; -; Genomic_DNA.
DR RefSeq; WP_068201197.1; NZ_CP014209.1.
DR AlphaFoldDB; A0A168EM58; -.
DR STRING; 1300344.I598_0628; -.
DR KEGG; ido:I598_0628; -.
DR PATRIC; fig|1300344.3.peg.631; -.
DR OrthoDB; 3567264at2; -.
DR Proteomes; UP000076794; Chromosome.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08297; CAD3; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR42940:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ANC30208.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076794};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 6..338
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 342 AA; 35923 MW; D4A3AD4C35616DE3 CRC64;
MTMKAAVVRE FRAPLDVTDA ELPTPGPGQA LVKVLYSGVC HTDLHAAHGD WPVKPTPPFI
PGHEGVGEVV AVADDVTRLH VGDTVGNAWL WSACGECEYC ETGRETLCPN QLNGGYSVDG
SFGQYMLVDA TYAPIVPAGV DLAAAAPILC AGVTVYKGLK ESEVKPGQWV LISGIGGLGH
IAVQYAHAMG MRVVAVDVSD DKLALARRHG AEATVNARTT DDVVARIHEV TGGGAHGGLV
TAVNGKAFPQ AVGGLRRGGT VSLVGLPPEE FGLDIFSTVL FGLTVRGSIV GTRKDMTEAL
DFFARGLIEP TYTVRPLADI NDIFDEMLHG AIDGRVVMDM QA
//
