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Database: UniProt/TrEMBL
Entry: A0A179H0G4_9HYPO
LinkDB: A0A179H0G4_9HYPO
Original site: A0A179H0G4_9HYPO 
ID   A0A179H0G4_9HYPO        Unreviewed;       988 AA.
AC   A0A179H0G4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   20-DEC-2017, entry version 11.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=VFPBJ_02503 {ECO:0000313|EMBL:OAQ83735.1}, VFPFJ_04675
GN   {ECO:0000313|EMBL:OAQ90515.1};
OS   Purpureocillium lilacinum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae;
OC   Purpureocillium.
OX   NCBI_TaxID=33203 {ECO:0000313|EMBL:OAQ83735.1, ECO:0000313|Proteomes:UP000078240};
RN   [1] {ECO:0000313|EMBL:OAQ83735.1, ECO:0000313|Proteomes:UP000078240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PLBJ-1 {ECO:0000313|EMBL:OAQ83735.1};
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT   Phytophthora in bio-control Purpureocillium lilacinum.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OAQ90515.1, ECO:0000313|Proteomes:UP000078340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PLFJ-1 {ECO:0000313|EMBL:OAQ90515.1};
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT   Phytophthora in bio-control Purpureocillium lilacinum.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAQ83735.1}.
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DR   EMBL; LSBH01000002; OAQ83735.1; -; Genomic_DNA.
DR   EMBL; LSBI01000004; OAQ90515.1; -; Genomic_DNA.
DR   RefSeq; XP_018179234.1; XM_018321755.1.
DR   EnsemblFungi; OAQ83735; OAQ83735; VFPBJ_02503.
DR   EnsemblFungi; OAQ90515; OAQ90515; VFPFJ_04675.
DR   GeneID; 28886804; -.
DR   KEGG; plj:VFPFJ_04675; -.
DR   KO; K10777; -.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078240,
KW   ECO:0000313|Proteomes:UP000078340};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:OAQ83735.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078340}.
FT   DOMAIN      432    557       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      725    805       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      886    987       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      191    211       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   988 AA;  113088 MW;  087245A0290EDF45 CRC64;
     MSRASQTQDT DAQREEEIQY GASDMTKEEL EDKYPNRPRN HSKTLAFHDL FLELFNPLNE
     NKKQPAGGPA RKKGPHGAHS LSPQEQRRHI IERFITRWRK DVGDDFYPAL RLILPDKDRD
     RGVYGLKESA IGKLLVKLMK IDKNSEDGYN LLHWKIPGQT MAARLAGDFA GRCFEVISKR
     PMRTDVGDMT IAEVNEQLDR LAASSGEAEN LRIFETFYNR MNAEEMMWLI RIILKQMKVG
     ATEKTFLYLW HPDGEALFSV SSSLRRVCWE LYDPAVRLEQ EEAGISLMQC FQPQLAQFQM
     PASFQRMIEL LRVTEEDPEF WIEEKLDGER MQMHMIEDPD HPGGMRFCFW SRKAKDYSYL
     YGNGFMDGNS ALTRHLKNAF ASGVRNLILD GEMITWDMGI DKIVPFGTLK TAALSEQQNK
     SNSDAAGHRP LFRVFDILYL NDKQLTQYTL RDRRRALEKA VNPVHRRLEI HSYTPATSAD
     AIEPLLREVV ANASEGLVLK NPRSMYRLNS RNDDWLKVKP EYMSEFGESL DCLIIGGYYG
     SGRRGGMLSS FLCGLRVTQN HIQAGANPEK CFSFFKVGGG FRGEDYAEIR HHTEGKWIEW
     DAKNPPSEYI ELGGGEAKQL ERPDMWIRPK DSVVVSVKAA SVGPSDSFAR GITLRFPRFR
     RLRLDRSWDS ALNVEEFQEL KKRVDEESKE KAMTVEDRKR RNPKRVKREI VIAGEDAAPV
     AFEGERSRVF EGLQFCVLSE SLKPYKKTKT QLETIVKENG GAVSQRAGKD MVYIADKKVV
     KAASLIKDGS VDIIRPRWIK DCLEQDDGAA YLLPYEESHL FHATEETRAA AMHNTDQYGD
     SYARDVSVEE LREIMADMPK LESLDAFDAP AFLRELEERQ KGLGEMRRFM FQGCVVHFRP
     VEGTSERLLG KLARYAKYAG GRVENELDEA VTHVVVVGDD AMEVGDVADQ VRKEVSGRRK
     IPRVVKGAWV QESWTEKTRL DEEQYTVQ
//
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