GenomeNet

Database: UniProt/TrEMBL
Entry: A0A193LCP3_9GAMM
LinkDB: A0A193LCP3_9GAMM
Original site: A0A193LCP3_9GAMM 
ID   A0A193LCP3_9GAMM        Unreviewed;       326 AA.
AC   A0A193LCP3;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|RuleBase:RU000422, ECO:0000256|SAAS:SAAS00369716};
DE            EC=1.1.1.37 {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|RuleBase:RU000422, ECO:0000256|SAAS:SAAS00369716};
GN   Name=mdh {ECO:0000256|HAMAP-Rule:MF_01517};
GN   ORFNames=BA177_02310 {ECO:0000313|EMBL:ANO50206.1};
OS   Woeseia oceani.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Woeseiaceae; Woeseia.
OX   NCBI_TaxID=1548547 {ECO:0000313|EMBL:ANO50206.1, ECO:0000313|Proteomes:UP000092695};
RN   [1] {ECO:0000313|EMBL:ANO50206.1, ECO:0000313|Proteomes:UP000092695}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XK5 {ECO:0000313|EMBL:ANO50206.1,
RC   ECO:0000313|Proteomes:UP000092695};
RA   Mu D., Du Z.;
RT   "Complete genome sequence of a deep-branching marine Gamma
RT   Proteobacterium Woeseia oceani type strain XK5.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate. {ECO:0000256|HAMAP-Rule:MF_01517,
CC       ECO:0000256|SAAS:SAAS00755561}.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|RuleBase:RU000422,
CC       ECO:0000256|SAAS:SAAS00369698}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01517}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP016268; ANO50206.1; -; Genomic_DNA.
DR   RefSeq; WP_068612383.1; NZ_CP016268.1.
DR   EnsemblBacteria; ANO50206; ANO50206; BA177_02310.
DR   KEGG; woc:BA177_02310; -.
DR   KO; K00024; -.
DR   Proteomes; UP000092695; Chromosome.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.110.10; -; 1.
DR   HAMAP; MF_01517; Malate_dehydrog_2; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR001252; Malate_DH_AS.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
DR   PROSITE; PS00068; MDH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092695};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|RuleBase:RU000422};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092695};
KW   Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU000422}.
FT   DOMAIN        5    152       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      156    321       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   NP_BIND      11     17       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   NP_BIND     129    131       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   COILED      300    326       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517, ECO:0000256|PIRSR:PIRSR000102-
FT                                1}.
FT   BINDING      92     92       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING      98     98       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     105    105       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     112    112       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     131    131       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     162    162       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
SQ   SEQUENCE   326 AA;  35004 MW;  617D0C79AC35603E CRC64;
     MKKPVRVTIT GAAGQIGYQL AFRIASGQML GSDQPIILQL LEIPQALDAL KGVVMELDDC
     AFPGLAGVVA TDDVNEAFRD SDYALLVGAR PRGPGMERKD LLQANAQIFS VQGKAMNDHA
     SRDIKVLVVG NPANTNALIA SSNAPDIDPR NFTAMTRLDH NRAAAQLAAK TGSHVTDIRQ
     LTIWGNHSAT QYPDVHHATV KGKAATDLVD QSWLSDDFIP TVQQRGAAII KARGASSAAS
     AASAAIDHMH DWALGTADGD WVSMGIPADG SYGIEAGIVY SYPVRCKNGD YEIVQDLEVN
     DFSRERMQAT EQELREERAA IEELLA
//
DBGET integrated database retrieval system