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Database: UniProt/TrEMBL
Entry: A0A194XQ22_9HELO
LinkDB: A0A194XQ22_9HELO
Original site: A0A194XQ22_9HELO 
ID   A0A194XQ22_9HELO        Unreviewed;       995 AA.
AC   A0A194XQ22;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   25-OCT-2017, entry version 10.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=LY89DRAFT_638376 {ECO:0000313|EMBL:KUJ22154.1};
OS   Phialocephala scopiformis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiales incertae sedis; Phialocephala.
OX   NCBI_TaxID=149040 {ECO:0000313|EMBL:KUJ22154.1, ECO:0000313|Proteomes:UP000070700};
RN   [1] {ECO:0000313|EMBL:KUJ22154.1, ECO:0000313|Proteomes:UP000070700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 120377 {ECO:0000313|EMBL:KUJ22154.1,
RC   ECO:0000313|Proteomes:UP000070700};
RG   DOE Joint Genome Institute;
RA   Walker A.K., Frasz S.L., Seifert K.A., Miller J.D., Mondo S.J.,
RA   Labutti K., Lipzen A., Dockter R., Kennedy M., Grigoriev I.V.,
RA   Spatafora J.W.;
RT   "Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal
RT   endophyte of spruce producing the potent anti-insectan compound
RT   rugulosin.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KQ947407; KUJ22154.1; -; Genomic_DNA.
DR   RefSeq; XP_018076509.1; XM_018211572.1.
DR   EnsemblFungi; KUJ22154; KUJ22154; LY89DRAFT_638376.
DR   GeneID; 28821298; -.
DR   KEGG; psco:LY89DRAFT_638376; -.
DR   KO; K10777; -.
DR   Proteomes; UP000070700; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070700};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:KUJ22154.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070700}.
FT   DOMAIN      433    558       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      726    808       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      928    993       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   995 AA;  113569 MW;  779190E254D2841B CRC64;
     MASQREPDDE AIQDDELQYG HGPMTMEELD DKYGGDEDTP RPRNHSKTPP FSELLVSLFN
     PLNDNKKRPT GPKVVAKKGP GSKTVSPHEQ RRNIIQQFIL RWRSQVGNDF YPALRLILPE
     KDRDRPMYGL KEKAIGKLIV KMLKINANGD DAQSLLNWKL PGQTTASRMA GDFAGRCFEV
     LSKRAMRQDF GDMRIAEVNE LLDRLSAVSK EEDQLPIFSQ FYNRMNADEL LWLIRIILRQ
     MKVGASEKTI LEMWHPDGEI LFNVSSSLRR VCWDLWDPSI RLDDDRRGIE LMSCFQPQLA
     QFSQHSIQKM IERMGCTSDN PEFWIEEKLD GERMQLHMKP DPNVKGGRKF AFWSRKGKDY
     TYLYGSSLED QNSSLTRFLK DAFDPGVESI ILDGEMITWD PVTRSMVGFG TLKTAAISEQ
     RNPYGETGHR PLFRIFDCLY INDKDITGFM LQDRREALER VVKNVDMRLE IHKYQVAATA
     AEVETELRKV IEEASEGLVL KNPRSVYRLN SRNDDWMKVK PEYMTEFGES LDCVVIGGYY
     GSGHRGGMLS SFLCGLRVDD NAIKAGADPM KCLSFFKVGG GFRAEDYAKV HHKTEGKWRK
     WDRNNPPRDL IVLGGNDNQQ FERPDEWIKP CDSVVLEVKA ASVAASDHYG YQYSLRFPRF
     KKLRDDKSWK EALSTYEFVE LKSRVEEESK NKALKIDTSR RASKRLKKEV LIAGNNTKIR
     TPYAGPQTKA FEGLSFWVMT GKEDQPKKTK AEMEQIIKSN GGKIVQSSTA TDSVICIGDK
     RVVKVASLIK SGETNIVKPA WVLDALKQVE IDGAERQRFL IPSEPAHMYH MLEEVREHIE
     GAVDDYGDSY ARDVNVDDLR RLMEDMIHPK DSEFSATEFL SELEERGKGF GEVPGSMFRR
     CVARFVPAND ETSGIDLEIA KNQFLFAGGT IAGDDEDDSI THYIVTSTDS KLVRDLRKSI
     SRGSLRIPRI VSLSWLSDSW KEKTVLDEEQ YAIVV
//
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