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Database: UniProt/TrEMBL
Entry: A0A1A9GGV9_9ACTN
LinkDB: A0A1A9GGV9_9ACTN
Original site: A0A1A9GGV9_9ACTN 
ID   A0A1A9GGV9_9ACTN        Unreviewed;       736 AA.
AC   A0A1A9GGV9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   07-JUN-2017, entry version 8.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:ANH36715.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ANH36715.1};
GN   Name=icd {ECO:0000313|EMBL:ANH36715.1};
GN   ORFNames=I601_0262 {ECO:0000313|EMBL:ANH36715.1};
OS   Nocardioides dokdonensis FR1436.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=1300347 {ECO:0000313|EMBL:ANH36715.1, ECO:0000313|Proteomes:UP000077868};
RN   [1] {ECO:0000313|EMBL:ANH36715.1, ECO:0000313|Proteomes:UP000077868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FR1436 {ECO:0000313|EMBL:ANH36715.1,
RC   ECO:0000313|Proteomes:UP000077868};
RA   Kwon S.-K., Kim K., Kim J.F.;
RT   "Complete genome sequence of a soil Actinobacterium, Nocardioides
RT   dokdonensis FR1436.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP015079; ANH36715.1; -; Genomic_DNA.
DR   RefSeq; WP_068105401.1; NZ_CP015079.1.
DR   EnsemblBacteria; ANH36715; ANH36715; I601_0262.
DR   KEGG; ndk:I601_0262; -.
DR   PATRIC; fig|1300347.3.peg.262; -.
DR   KO; K00031; -.
DR   Proteomes; UP000077868; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000077868};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ANH36715.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077868}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       346    346       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       544    544       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     543    543       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        416    416       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   736 AA;  79500 MW;  AA0E7ACFE8DDACFD CRC64;
     MATIIYTHTD EAPLLATYSF LPIIQAYAAK AGVEVETRDI SLAGRILAQF PERLTEEQRV
     ADHLAELGEL ATKPEANIIK LPNISASTPQ LKAAVKELQE KGYDLPDYPE HPQTEDEKDA
     RAKYDKVKGS AVNPVLREGN SDRRAPAAVK GYAKKYPHRM GEWKSDSKTT VTTMDGGDFF
     SNEQSVVLDA ADTLSIVHVG ADGTETVLKD ALPVEAGEVV DATFMSVAAL RRFLTEQIAR
     AKADDVLFSV HLKATMMKVS DPIVFGHAVQ AFFPTLFEQY GAQLAEAGIS PNDGLGALMS
     AVDSLPDGEA IKASVKQGLA DGPRMAMVDD RKGITNLHVP SDVIIDASMP AMIRIGGHMW
     GPDGQEDDCL AVIPDSSYAG VYAAVIEDCK AHGAYDPATM GSVPNVGLMA RKAEEYGSHD
     KTFEIADAGT VVVRNAAGET LMSHEVEPGD IWRACQTKDE PIRDWVKLAV TRARASGSPA
     IFWLDENRAH DANLIKKIEA YLPEHDTDGL TIEVMTPAEA TTYSVERIRK GEDTISVTGN
     VLRDYNTDLF PILEVGTSAK MLSIVPLMNG GGLFETGAGG SAPKHVQQLI EQNYLRWDSL
     GEFFALAASF EHLAGYADNR GAKVLADTLD AATATFLEED KSPTRKIGGI DNRGSHFYLA
     LYWAQELAKQ TADTDLAKVF APLAEKLAAE EETIVSELNA VQGSPADVGG YFRPQDDKAD
     QVMRPSTTLN EALASL
//
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