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Database: UniProt/TrEMBL
Entry: A0A1A9J492_9ACTN
LinkDB: A0A1A9J492_9ACTN
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ID   A0A1A9J492_9ACTN        Unreviewed;       739 AA.
AC   A0A1A9J492;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   05-JUL-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ANH94573.1};
GN   ORFNames=A8713_28155 {ECO:0000313|EMBL:ANH94573.1};
OS   Streptomyces sp. SAT1.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1849967 {ECO:0000313|EMBL:ANH94573.1, ECO:0000313|Proteomes:UP000078022};
RN   [1] {ECO:0000313|EMBL:ANH94573.1, ECO:0000313|Proteomes:UP000078022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAT1 {ECO:0000313|EMBL:ANH94573.1,
RC   ECO:0000313|Proteomes:UP000078022};
RA   Dou G.;
RT   "Complete genome of endophytic Streptomyces sp.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP015849; ANH94573.1; -; Genomic_DNA.
DR   RefSeq; WP_064536482.1; NZ_CP015849.1.
DR   EnsemblBacteria; ANH94573; ANH94573; A8713_28155.
DR   GeneID; 32628771; -.
DR   Proteomes; UP000078022; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000078022};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79592 MW;  3B70FFD288F468B5 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA VFPEYLSEDQ
     RIPDALTELG ELAKTPEANI IKLPNISASI PQLKAAIAEL QGQGYALPDY PDDPKSDEER
     DIRARYDKIK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTGESK TNVATMGADD
     FRSTEKSVVI AEDGALRIEL KGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLTEQV
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA KYGEAFAAAG LTPNDGLGGI
     HKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEHD TLAVLPDSSY AGVYQAVIED CRAHGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPVT GTVRLVDQAG NAVLEQAVSA GDIFRACQTK DAPVKDWVKL AVTRARATGD
     PAVFWLDETR AHDANLIAKV KQYLPEHDTE GLDIRILAPE EATRLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAEATG NTRAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA RQTDDADLAK AFAQLAETLA GSEQQIVDEL NAVQGEPADI GGYYQPDPAK
     AAAVMRPSAT WNEALAALS
//
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