ID A0A1B1ZY15_9PSEU Unreviewed; 9436 AA.
AC A0A1B1ZY15;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:ANY10600.1};
GN Name=selI {ECO:0000313|EMBL:ANY10600.1};
GN ORFNames=AFB00_29780 {ECO:0000313|EMBL:ANY10600.1};
OS Pseudonocardia sp. HH130630-07.
OG Plasmid pls2-1 {ECO:0000313|Proteomes:UP000092926}.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1690815 {ECO:0000313|EMBL:ANY10600.1, ECO:0000313|Proteomes:UP000092926};
RN [1] {ECO:0000313|EMBL:ANY10600.1, ECO:0000313|Proteomes:UP000092926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HH130630-07 {ECO:0000313|EMBL:ANY10600.1,
RC ECO:0000313|Proteomes:UP000092926};
RC PLASMID=Plasmid pls2-1 {ECO:0000313|Proteomes:UP000092926};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; CP013855; ANY10600.1; -; Genomic_DNA.
DR KEGG; phh:AFB00_29780; -.
DR OrthoDB; 3653264at2; -.
DR Proteomes; UP000092926; Plasmid pls2-1.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 5.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 6.
DR Gene3D; 3.10.129.120; -; 1.
DR Gene3D; 3.30.70.3290; -; 6.
DR Gene3D; 3.40.47.10; -; 6.
DR Gene3D; 6.10.140.1830; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 6.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 6.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 6.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 6.
DR Pfam; PF00109; ketoacyl-synt; 6.
DR Pfam; PF02801; Ketoacyl-synt_C; 6.
DR Pfam; PF08659; KR; 6.
DR Pfam; PF18369; PKS_DE; 5.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 6.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 6.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 6.
DR SMART; SM00825; PKS_KS; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 6.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 6.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 12.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 6.
DR SUPFAM; SSF53901; Thiolase-like; 6.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00606; KS3_1; 6.
DR PROSITE; PS52004; KS3_2; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:ANY10600.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000092926};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..446
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1654..1729
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1747..2169
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3172..3247
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3265..3689
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4728..4803
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4822..5244
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6273..6348
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6372..6790
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 7710..7785
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 7803..8216
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 9226..9301
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 9197..9218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9294..9322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9356..9415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 9436 AA; 969524 MW; BE3038B69DB50C2F CRC64;
MDNEQKLRDY LKRASADLQR TRQRVQELEE ASREPIAIVG MSCRYPGGVA GPDDLWQMVA
TGSDGISGLP TDRGWDLDGE LAAAATSGGF LHDAAEFDAD FFGISPREAL AMDPQQRILL
EAAWEAFERA GVDPASVRGS RTGMFIGAMA QDYRVGPDDG VEGFVLTGSS GSVVSGRLAY
SFGTVGPAVT VDTACSSSLV SLHLAAHALR AGECSMALAG GITVMSTPAT FLEFARQGGL
ATDGRCRSFA DSAAGTGWAE GVGVLVLERL SDAQRNGHEV LAVVRGSAVN QDGASNGLTA
PNGPSQQRVI TEALTHSGLS ADQVDVVEAH GTGTTLGDPV EAQALLATYG QRRERPLWLG
SVKSNISHTQ AAAGVAGVIK MVEAIRHGVL PATLHVDTPS SKVDWDSGQV RLLSESMPWP
ATGAPRRAAV SSFGISGTNA HTILEQAPDA PVVESAHDAD GTGPAPLLLS GRTAEALSAQ
AERLLDRLDA ADAPDLRDVA FSLATGRASL EHRAVVPADD AGQARAGLRE LAEGTTAPGS
VRGTSRRRPA TAFLFAGQGS QRLGMGRELH RRFPVFAEAF DAVCAHLDPS VREVVWGTDA
DALDDTGVAQ PALFALEVAL HRLVSSYGVR PTQLIGHSIG EIAAAHVAGV FSLPDACALV
TARGRLMRSL PAGGAMVAIA ASEEEVAPHL TDGVSLAAVN GPSSVVVSGT EPEVHDVVEH
FADRRTRRLR VSHAFHSPLM EPMLAEFRAV VAGLDACAPT LPIVSTLTGR PATAEELGSA
EYWAAHARGT VRFVDAVATA RTLGVTDLLE LGPDATLCGA ARSCLDAAGA EDAATLPVLR
ADRDEAATLA EAMAGLYVRG VAVHRNSLVD GTGAHRVDLP TYAFRHRRFW PKGPAAAGGD
VRAAGLGAAH HPLLAAAVAL ADSDGVLLTG RLSIAAQPWL ADHAVYGRVL LPGTAFLELA
IRAGDEVGAD HVEELTVAAP LVLPGSGGVG VQVWLGSPDA SGRRVVTVYS RPDDADDEPW
TRHATGVLGR GGPAAVTASA TTGPEWPPAG AEALDVTGAY DSLAAAGLEY GATFQGLRAA
WRRDDEVFAE VALPQSAGTE GFGVHPALLD AALHALAIAG SGEDTGTSLP FSWGGARLHA
GGASAVRVRI TGAGTDTVSL VVSDPAGDPV ATVASLVLRP LPDGGVASDI GRTPLFAVEP
TSVRLGEAPA SFALLDPGGL LGSTFAPAPL YDSLAELAEA GVPEVVAAPV PAVEGDVPGA
VRAVTAWALD LLQRWLADER FAGSRLVLLT RGADLDPVHA SVVGLARTAQ AEQPGRVAVL
DLGPDGSAAD TPSPATVVAA LGTADEPELA LRGEDAVAPR LTRLLPPGAA GTPAPFDADS
TVLITGGTGG LGAVIARHLV AGHGVRSLVL AGRRGPEAPG AAELAAELTE AGAEVAVVAC
DAADRDQLAA LLAQHPVTAV VHSAGVLDDA TITSLTPAAF ETVLAPKVDA AQNLHELAGD
LTAFVLFSSV AGTAGAAGQG NYAAANAALD SLAARRRAAG LPATSLAWGP WSATGGMTGE
LTDADLARLA RAGTPALEPE QGRELFDAAL AADRATVVPV RLDLPLLRAR GEVPAFLRGL
VRGPARRTAA ADTAGPGSGV AGLWRGLDAA DRDAAVLALV RDEVAAVLGH GSGAEIDPDR
AFTDLGFDSL TAVELRNRIA STTGLRLPTT LVFDYPTTSA LAGHLISATV GGDGPARPVT
PVLATGDDPV VIVGMACRYP GGVSSPEDLW RLVTDGGDAI SGFPTDRGWD LETLHDPDPD
RRGTTYASGG GFLHSAPEFD PGFFGMSPRE ALATDAQQRL LLESSWEAFE RAGIDPRTLR
GSATGVFAGL MYNDYGSILA RGDFEGLQGS GTAPSVASGR VAYALGLEGP AVTIDTACSS
SLVAMHWAAQ ALRSGECSLA LAGGVTVMST PAAILEFSRQ RGLSPDGRCR AFSDDADGVG
WSEGVGMLVL ERRSDALRNG HQILAVLRGS AVNSDGASNG LTAPNGPSQQ RVIRAALAGA
GLGTADVDVV EAHGTGTTLG DPIEAQALLA AYGQDRETPL YLGSVKSNIG HTQAAAGVAG
VIKMVEAMRH GVLPVTLHAS TPSSHVDWDA GEVELLTEPL PWVTDGRARR AGVSSFGISG
TNAHLILEAP EPAQLPAPGT ALPDTALPAA PLPIVVSGRT PAALRDQAAR LSRHLDAHPD
TDLGDVAASL LGTRTAFEHR AAVAAEDHDG LRRALDALAT GAAATGLVEG TPTGGRTAFL
FAGQGSQRPG MGRELYARFQ AYAAAFDAVA AHLPAEVLDA ALGDDADALT RTGHAQPGLF
ALEVALYRLV ESWGIVPDRL AGHSIGEIAA AHVAGILSLP DACALVSARA RLMQALPAGG
AMVAVAASED EVVPHLSDGV AIAAVNGPSS VVVSGAEAEV EAVVARFADR RTKRLRTSHA
FHSPLMAPML DEFRTVVEGL SFAAPRIPVV STVARGADLT DPGYWVEHVR ATVRFADAAA
ALADDGVTTA LELGPDGVLC ALVESAAPDR IAAAPVLRPD QPETRTVVAA LGHLWVHGVD
LPATPGGAAG PARRVDLPTY AFQHEHFWPD VPAAGAATDG DGSADQALWG AVERQDDTEV
AALLGLTDDR HAALSALLPA LSSWRQGRHE KARLDRWRYR TGWTSRRVTA GARLDGTWLL
VRADDPAGQA RATEVADALR AAGAEVADLV LDAACTDSAE TAARLSARPA ELTGIVSLLP
LAERPAAHRP QVPLGLALTG ALVQALAAIE SATPLWTLTA GAVRTGPADP APHTDQAAVW
GLGRVAALEH PRLWGGLVDL PAEPHPNALD RLAAVLTGPA GEDQVALRAG TAWGRRLYRH
PVDALPPETA FTVSGSVLVT GGTGALGGEV ARLLARSGAR HLVLTGRRGP DAPGAADLAA
ELEGLGASVH VAACDVTDAD AVADLLAAVP AEHPLTGVVH VAGIGQASTL EDTGPAEFDR
VYAAKVTGAR VLDDLLGDRE LDLFVLFSSI AGVWGSRGQA AYAAGNAALD ALAEERRARG
LVATSVAWGP WADAGMATDD AVAADLARAG LRALPPAPAV TELRRALVQD DTCVTVADVD
WQRYAPVFTA ARASALFDPI DDVAALDRAP DDAAGGELAR RLRDLDGAAQ QRLLLDLVRA
EAAAVLGHGT ADAVAATRSF RDAGLDSLTA VELRKRLVGL TGLALPATLA FDHPSPSALA
EHLREQLLGL TDAGGPVAAT TAVDDEPIAI IGMGLRFPGG VATPEQFWDL ISGGVDATGE
FPTDRGWDAD GLHDPDPDRP GRTYTTRGGF LHDAAEFDPA FFGISPREAL SMDPQQRLLL
QTGWEAFERA GIDPATLRGS RTGTFVGSSF QDYGAGAAAG NGASEGHMVT GTIPSVLSGR
LSYLFGLEGP AVTVDTACSS SMVALHLACQ SLRSGESTLA LVGGATVMAT PAPFVAFSRQ
RALAADGRCK AFGSGADGMS LGEGVAVLLV EKLSDARAHG HEVLAVVRGS AVNQDGASNG
LTAPNGPSQQ RVIRQALANA GVEPGEVTAL EAHGTGTPLG DPIEAQALMA TYGLDRDPQR
PLLLGSVKSN IGHTQSAAGV AGVIKMVLAM RYGLLPPTLH AGEPSAQIDW SPGGVALVDE
PTEWPEGSRR AGVSSFGISG TNAHVILEEG DRVPARAEQV TVDAQDASAD GLEPDAPAPA
TPAALPFLIS ARGAEPLRDR AAAIASLLGV ADAPAPADVA FSLATTRAQM VDRAVVVGTG
TDEPAERARA LAAGEPAAGI VTGTADVDGR TVFVFPGQGA QWAGMGAELA AASPVFAARL
DECAAALSPH VDWVLRDVLT GAEGTPTLER VDVVQPASFA VMVSLAAVWA AHGVTPDAVL
GHSQGEIAAA VVSGALSLDD GARVVALRSR AIAEHLSGAG AMMSVALPAD EVRALLAEHP
GELSVAAVNG PRSVVVCGEP DAVTALGEQL QAREVRARRI AVDYASHSAY VEAVEEPVRA
ALAPITPVAS SVPFLSTVTG DWLDTTTMDT GYWYENLRRE VRFAPAVRAL LEQGHRRFLE
ISPHPVLTIG ISETVEELGA DLGGPALVSG TLRRDEGGPD RVLTALAQAW VRGVDVDWTP
AVDGGRRVAL PTYPFRREHL WAIAEPVATL RESDAAEVAF WDAVDAQDLD TLSSDLDLDA
GTDGASLAAV LPALADWRRR HRERDTLDAW RYRTVWKPLP NTAPGVLEGT WLLVGTGGTG
ADGAVARTLR EHGAEVRYVE LDPTGTDRAE VAARLGSGPV AGVLSLLAAD ERPLAEGTAD
EQPSLTRGVA LIVALIQALG DAGVTAPLWS VTTGAVSTGR ADPVTAPLQA LVQGVVWTAA
LEHPERVGGT VDLPAELDQR AAARLAGVLA GHTGEDQVAL RDSGVFARRV VRAAPGAAPG
GPGWTPRGTT LLTGGTGTLA PHIARWLARR GAEHLVLTSR RGPDAPGAAQ LLAELAELGT
EAEMVACDLG DRESVVGLLE GLRAGGRTVR TVLHTAVSIT LAAIDETGPE QVADVLRAKV
DGARHLDELL DDDELDAFVL FSSTAGMWGS GAHAAYVAGN AYLAALAEQR RARGVPATAI
SWGIWADDRD LGRVDADQIL RSGLVFMDPA TALAGLARAL DERDTVLAVA DIDWERYHPV
FTAVRESTLF SELPEMRRPA AAPEPAAAAA GGALATRLAG LSPADTDRVL VDIVRAEAAT
ALGLSGPSEL GERTAFRDVG FDSLTAVELR NRLAAATGLT LPTTTVFDHP NPVALAAFLR
SMVTGDTATP PTGPVPAAAV DDEPVAIVAM SCRYPGGVGS PEQLWDLVTG GVDAVSGFPA
DRGWDAEAIF DPDPDHPGTT YSTQGGFLHD VADFDADFFG ISPREALSMD PQQRLLLETA
WEAFERAGVD PATLRGSTTG TFVGASYQDY SAGAGEGGSE GHMVTGALSS ILSGRVAYLL
GLEGPAITLD TACSSSLVAL HLACRSVRSG ESSLALAGGV SVMSTPDAFI GFSRQRAMAV
DGRCKAYSDS ADGMTLAEGV GLVLVERLSE ARRLGHPVLA VIRGSAINSD GASNGLTAPN
GPAQQRVIGA ALADAGLTPA EIDVVEGHGT GTALGDPIEA QALLATYGQD REHPLLLGSV
KSNIGHTQMA SGIAGVIKTV LAMRHGVVPR TLHVDRPSTH VDWSAGEITL ARDEFSWPRT
GRPRRAAVSS FGLSGTNAHT VLEQAPDEAE DVTEPAQVCV PVIVSGRSRE ALKAQAAALR
ERLAEGVHPT DLAYSLATSR GLFSHRAAVV TGGPDSDPDA LDRALSAIAD DRPDPALIRN
DTAGAGPARG GLAVVFTGQG SQRPGAGREL YRAFPAFADA LDEILARFDT ELDRPLREVM
FAEDGSPDAA LLDRTGYTQP ALFAIEVALF RLVESWGVHP DQVAGHSIGE LAAAHVAGVL
SLDDACTLVA ARGRLMEALP PSGTMIAVEA SEDEVTPLLT DGVAIAAVNG PRAVVVSGDA
DGTRAVAAQL AAGGRRTREL TVSHAFHSPL MDPMLAEFTA IASRLRFHAP RIPLVSDLTG
EPVDAEAVTT AQYWADHVRG AVRFADVVRG LVAAGAGAVL ELGPDAVLTA MARDTLDADG
LGADVALVPS LRRDRPEAAA LTAALAGLVV HGAQTELGAF FAGTGARRVD LPTYAFRRRR
FWPEPTAAGA TPTGTTDPVD AEFWAAIEHA DLDTLATELE LDGTTLGTVV PALSSWRRRR
TERNAVDGWR HRVTWAPLQS SRDAVVDGTW LLVGTPDTAP LADALAGVLG QRTVRFETTT
AERSDLAAGL TARLAEAAAP VTGVVSLLAT TPGEVTTAAG PVPAGLVATT TLLQALGDAG
ITAPLWALTR GAVSTGRSDP LRSPEQAAVW GLGRVAALEH PDRWGGLADL PGDASASDPS
VLRRLAGALA ATPGSGEDQI AVRTSGVLGR RLSTAPDTTR AADGVDLADL AGSTVLVTGG
TGGIGARLAR QLAGAGVAHL LLVSRRGPDA PGADPLRAEL TALGAGVTLV AADVADRDAM
AQVLAGAPAD APLRAVFHTA GVVDDGVLDG LTPERLGTVL RAKAGAVAVL DELTADHDLA
AFVLFSSVAG TIGAAGQGNY AAANAVLDAA AVVRRAAGRP ATSVAWGPWD ETGMVADGDG
VARRVARGGL HPMAPERALG ALWTALAHGD TTVVVADVDW SRFAPVLSAS RPAPLVADLP
QVRALAPTAV EAGPAAPDLV RTLAARPDAE RAGVVAELVT ATVAGVLGHG DPSAITADRA
FTDLGMDSLT TVELRNALGA ATGLTLPTTV VFDHPTPGAL AAHLLSELRL GEPAAAVPAH
RAASAGTGHD PDDPVVIVGI GCRYPGGVTS PEELWDLVDA GRDAITGFPA DRGWDLESLA
AGGSDTGHGG FLHDVADFDA GFFGISPREA LAMDPQQRLL LETAWEACER AGIDPRSLRG
ADAGVFVGTN GQDYPQMLRR ARADVAGHVA TGNTASVLSG RLSYVLGLEG PAVTVDTACS
ASLVALQWGA AALRSGECSL VFAGGVSVMA GPDSFREFST QSGLAPDGRC KAFGDGADGT
AWSEGAGVLV LERLSDARRH GHPVWAVVRG GAINQDGASN GLTAPSGPAQ QRVIRTALAD
ARLGPADVDA VEAHGTGTTL GDPIEAGALI ATYGADRSEP LRLGALKSNI GHSQAAAGVG
GVIKMVMAMR HATLPRTLHA ETPSSHVDWA AGAVSLLAEA APWPERGRPR RAGVSAFGVS
GTNAHVIVEQ APAEAEAPAA EPVGHVPWVV SGAGRAALDD QIARLDGHPG STVDVGWSLA
TGRTAFRYRA VLLADGSTTT EVARGTAVTG GRLAALFTGQ GSQRPGMGRD LYARFPVFAD
AFDAVCAHLD TELDRPLRDV VWGEEPGELT HTGYAQPALF AIEVALHRLL ESWGVVPDVL
AGHSVGEIAA AHVAGVFSLA DACTLVAARG RLMQALPTGG AMVALGASED EVTPHLTGGV
AIAAVNGPTS VVVSGTEAEV EAVVARFADR RTTRLRVSHA FHSPLMDPML DDFRRVVQGL
ELAEPTRPVI TALAGTTGAD MAGPDYWVRH VREPVRFADA VAGLVAAGAT GYLEIGPDGP
LSAMAAPMID DPDVVCVPAL RRDRDEVATL TTAVARLHVT GVPVDWARWF DGTGARRVDL
PTYAFQRSRF WPEPAPADAA GTDPVDAAFW DAVERGDLES LAGTLHVGDD TLSAMVPALS
AWRRDRRERT AADGLLYATT WRQITDREIT DRATPEQAPR VLLLVPSGTG SHDHLEHLDA
IRVEVGPDGD LTGAETDVDV VLSLLDTAPA ELLAALDRAG VDAPLWCATR GAVAVDHTES
PTDLDAAARW GAARTTARTA PERWGGMVDL DLDPDLDAAG AAALAEVLTG RHGDEIAVRG
GRVLARRLVR ADGATRPWTP NGTVLVTGPA DGLGGRIARR VAARGAERVL LLDPAGPDTP
AAVTLHEEIG VTVVATRAAD YSADRAPAFD GDTPTAVVHA EPAGRSAVDG ALALDAALPD
VDAFVLCTTI AATWGVRGQD ADAETGAAYT AIAERRAARG ASGTALAFAA WSGLVENSMA
AHLRLNGLPT LDPDRALSAL GAAVAAGTSV TVADVDWATF APSFAPGRIA ALLDELPEAR
RAITDTSTAP AGDAELSARL AGLTAEQGAE VVLDLVRAEA AHVLGHDGPA AVEPDLPFTD
LGFDSLTAVD LRNRLTAATG LTLPATLVFD HPTPDALAEQ LRSELTGQRS AVADTSVTVA
DADDPVVIVG MSCRYPGGVR SPEDLWRLLT EETDAVGGLP VDRGWDLDRL AAGRGVSRAG
GFLHDVADFD PGFFGISPRE AMVMDPQQRI VLEAAQEAFE RAGIDPSTLR GSDTGVFVGG
GTGDYRPPSG QEGHSATAQS ASLISGRLSY TFGLQGPAVT VDTACSSSLV ALHLAAQAVR
AGECSIALAG GVTVMSTPVG LVEFGEMGAL SPDGRCKAFS DSADGTGWSE GVGLLVVERL
SQARLRGHEV LAVLRGSATN QDGASNGLTA PNGGAQQRVI RRGLAVAGLS PAEVDAVEAH
GTGTTLGDPI EAQALLATYG QDRTEPLLLG SVKSNIGHTQ SASGVAGVIK MVLAMQHGTL
PATLHVDRPS SHVDWSAGSV SLLTRARPWP ETGRPRRAAV SSFGASGTNA HAILEQAPAV
EAPAAPRTSR TVVPVPVSGR SAAALRAQAQ RLREHVARTG DGVADIAFSA ATTRAAFEHR
GAVVAATHDE LLDGLAALAE GRRGPGVVDD RAVRRGRTAF LFAGQGSQRL GMGRQLHERL
PAFAAAFDEV CDRLAGHTDV DVRAVVHGTD ADALDRTGNA QPALFALEVA LYRLLESWGV
TPAFVAGHSV GEIAAAHVAG VLSLDDACAL VAARGRLMQA LPTGGAMVAV SATEEEVTPL
LTAGVAIAAV NGPTSIVVSG DADQVEAVVA PLREQGRRTR RLPVSHAFHS PLMDPITEDF
RAVCASLTFH APSIPVVSTL TGRIAEDGEL GDPEYWVRHA RHAVRFADAV TTLAGRGVTV
FGELGPDSTL AALARESLPG GDTVTVAGLL RRDRDEETTL VSGLATLAAG GAGGAGVDWP
AFFAGTGARR VALPTYAFQH ARFWPKPVAP AAPAGAAGDD SAFWDVVERG DLAGLAGTLG
VEHGELSAVL PALGEWRRRH RERSVTDGWR QRITWTPLTG LPQARPSGTW LAVLPAGLAG
DAWVRATLDA LGTGVVPLEV GAGTSRAELA AQLSPHVGAV SGVLSLLALA DPEPDAVVPA
GTTATATLVQ ALGDAGLPAP LWAVTRGAVS VAATEAPARP EQAGVWGLGR VAALEHPDRW
GGLVDLPEAA GDIDDAVAAR LAAILAGHEH EDQVAIRASA AFGRRLVAAG DSDDDTAWEP
TGTVLITGGT GALGAQVARH LATTRSDDGR APHLLLAGRR GPDAPGADDL VAELTGLGAQ
VTVAACDVAD RTQLTALLDG VGDERPLTAV VHTAGVLDDG VLDGLTPERF AAVFRSKVTS
ALLLDELTGD LDAFVLFASA SAAVGNAGQA NYAAANAVLD ALAERRRANG RAATSISWGA
WGGAGMAAGA DAEEVSRRTG VTPMDPDRAV ATLRRLAGGH QATAVVSDVD LARFVRTFTA
ARPSPLLREL PGYADLAATT PEPAGTDSGP SLREKLAGLS PARRRRTLLE LVCGRTADIL
GYGGADEIGP DRAFRDLGFD SLASVELRNQ LGAATGLSLS ATLVFDHATP GELADHIGTE
LGSGSGSGPD SGSDPGPDAQ EAEEAGIRAL LASVPLELLR ESGLLDPVLA LAGSPTHGHA
GGNGHAAADG HTAGNGNGNG HAGGNGHAGG NGHAGGNGHA AAHGPDGDDG AIDDMAIDDL
VRAALDNEHD EDRSAR
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