GenomeNet

Database: UniProt/TrEMBL
Entry: A0A1B2H0Z6_STRNR
LinkDB: A0A1B2H0Z6_STRNR
Original site: A0A1B2H0Z6_STRNR 
ID   A0A1B2H0Z6_STRNR        Unreviewed;       740 AA.
AC   A0A1B2H0Z6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   22-NOV-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase (NADP) {ECO:0000313|EMBL:ANZ19854.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ANZ19854.1};
GN   ORFNames=SNOUR_33110 {ECO:0000313|EMBL:ANZ19854.1};
OS   Streptomyces noursei ATCC 11455.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=316284 {ECO:0000313|EMBL:ANZ19854.1, ECO:0000313|Proteomes:UP000093521};
RN   [1] {ECO:0000313|EMBL:ANZ19854.1, ECO:0000313|Proteomes:UP000093521}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11455 {ECO:0000313|EMBL:ANZ19854.1,
RC   ECO:0000313|Proteomes:UP000093521};
RA   Ruckert C., Albersmeier A., Winkler A., Zotchev S., Kalinowski J.;
RT   "Complete genome sequence of Streptomyces noursei ATCC 11455, a
RT   producer of the medically important antifungal antibiotic nystatin.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP011533; ANZ19854.1; -; Genomic_DNA.
DR   RefSeq; WP_067353900.1; NZ_CP011533.1.
DR   EnsemblBacteria; ANZ19854; ANZ19854; SNOUR_33110.
DR   GeneID; 34157169; -.
DR   KEGG; snr:SNOUR_33110; -.
DR   PATRIC; fig|316284.13.peg.7043; -.
DR   KO; K00031; -.
DR   Proteomes; UP000093521; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000093521};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ANZ19854.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  79329 MW;  D9D3239D1652FA33 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVEAYA ATAGVTLETR DISLSGRIIA SFPERLKEDQ
     RIADALAELG QLAKTPGANI IKLPNISASI PQLKAAIAEL QEQGYALPDY PDDPKTDEER
     ETRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWTADSK TNVATMGEND
     FRSTEKSAVI AEDGSLRIEL VAEDGTTTVL RESVPVLAGE VVDASVMRVA QLREFLAAQV
     ARAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA RYGEALAAAG LTPNDGLGGI
     FKGLEALPDG AEIKASFDAE LAEGPELAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEAD TLAVLPDSSY AGIYQAVIDD CRAHGAFDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEVAVA GTVRLVDAQG NVVIEQAVAA GDIFRACQTK DAPIKDWVKL AVSRARATGD
     PAVFWLDETR AHDAQLIAKV NAYLSEHDTE GLEIKILAPV EATAFSLERI RRGANTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLATTTD NTRAKVLADT LDRATGSFLN ENRSPSRKLG GIDNRGSHFY
     LALYWAQELA KQTDDAQLAE AFGPLAKTLT EQEQTIVDEL IAVQGSPVDI GGYYRPDPAK
     ASAVMRPSKT LNQALAALQG
//
DBGET integrated database retrieval system