ID A0A1B4C2E5_9BURK Unreviewed; 662 AA.
AC A0A1B4C2E5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
DE Short=Beta-gal {ECO:0000256|PIRNR:PIRNR001084};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|PIRNR:PIRNR001084};
GN ORFNames=WI26_26595 {ECO:0000313|EMBL:AOI61086.1};
OS Burkholderia diffusa.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=488732 {ECO:0000313|EMBL:AOI61086.1, ECO:0000313|Proteomes:UP000094588};
RN [1] {ECO:0000313|EMBL:AOI61086.1, ECO:0000313|Proteomes:UP000094588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RF2-non-BP9 {ECO:0000313|EMBL:AOI61086.1,
RC ECO:0000313|Proteomes:UP000094588};
RA Sahl J., Wagner D., Keim P.;
RT "Diversity of Burkholderia near neighbor genomes.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|PIRNR:PIRNR001084};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940, ECO:0000256|PIRNR:PIRNR001084}.
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DR EMBL; CP013363; AOI61086.1; -; Genomic_DNA.
DR RefSeq; WP_069227708.1; NZ_CP013363.1.
DR AlphaFoldDB; A0A1B4C2E5; -.
DR KEGG; bdf:WI26_26595; -.
DR Proteomes; UP000094588; Chromosome 2.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR PIRSF; PIRSF001084; B-galactosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|PIRNR:PIRNR001084};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001084}.
FT DOMAIN 6..390
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 404..605
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT ACT_SITE 142
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT ACT_SITE 313
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-1"
FT BINDING 103
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 141
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
FT BINDING 321
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001084-2"
SQ SEQUENCE 662 AA; 74353 MW; 3745E305D63F8AD7 CRC64;
MRLGVCYYPE HWPESMWADD ARRMKALGIA QVRIAEFAWS RIEPSPGEYD WGWLDRAVDV
LGAAGLEIVM CTPTATPPKW LVDRHPDILA IGADGRPRTF GSRRHYDFSS PTYLEASRRI
CSAVAERYGR HPAVRYWQTD NELGCHQTVV SYSPAALVRF RAWLQARYGT IDALNRAWGT
VFWSMEYRHF DEVDAPVGTV TEAHPSHRLD YRRFASDELA RYHRMQVAVI RTHSPGRPVA
HNFMQLFTEF DHYEVARDLD VATWDSYPLG ALEEQWFAPD VKARWLRTGH PDFASFNHDL
YRGMSKLPFW VMEQQPGPVN WAHWNPAPLP GMVRLWSWEA FAHGAGCVSY FRWRQAPFAQ
EQMHAGLHTP DDRLDEGGRE AQRVAREIAA VLDAGADANG AVRAPVALVF DYEAKWLFEV
QPQGADFHYP RFAFEYYSAL RSLGLDVDIV SAHAPLDGYR LVVVPPLPIV PDDFAARLAA
SGAHAVFGPR TGSKTVDLRI PPALPPGPLA SILPVRVWRV ESLRPNVTER IDGTLHDGAP
LTGDARHWRD LVELNDDDVH SVVRARFADG HPAWVSHGTL HYWAALFDDA TTARLFADVA
VEAGLTPSPL GDGVRVSRRG GLTYVFNYGS TPHTIDAVQP SAFVVGAAQV ERQGVAVYRS
RS
//