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Database: UniProt/TrEMBL
Entry: A0A1D7VJM7_9ACTN
LinkDB: A0A1D7VJM7_9ACTN
Original site: A0A1D7VJM7_9ACTN 
ID   A0A1D7VJM7_9ACTN        Unreviewed;       739 AA.
AC   A0A1D7VJM7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-SEP-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase (NADP(+)) {ECO:0000313|EMBL:AOP46952.1};
GN   ORFNames=SL103_12440 {ECO:0000313|EMBL:AOP46952.1};
OS   Streptomyces lydicus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=47763 {ECO:0000313|EMBL:AOP46952.1, ECO:0000313|Proteomes:UP000094094};
RN   [1] {ECO:0000313|EMBL:AOP46952.1, ECO:0000313|Proteomes:UP000094094}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=103 {ECO:0000313|EMBL:AOP46952.1,
RC   ECO:0000313|Proteomes:UP000094094};
RA   Jia N., Ding M.-Z., Gao F., Yuan Y.-J.;
RT   "Complete genome sequencing of Streptomyces lydicus 103 and metabolic
RT   pathways analysis of antibiotic biosynthesis.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP017157; AOP46952.1; -; Genomic_DNA.
DR   RefSeq; WP_069568913.1; NZ_CP017157.1.
DR   EnsemblBacteria; AOP46952; AOP46952; SL103_12440.
DR   GeneID; 32338420; -.
DR   KEGG; slc:SL103_12440; -.
DR   KO; K00031; -.
DR   Proteomes; UP000094094; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000094094};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094094}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79994 MW;  FE9460550E6C814D CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIQAYA SQAGVSVETR DISLAGRIIA SFPEHLEEGQ
     RIDDALAELG ALAKTPEANI IKLPNISASI PQLKAAIAEL QEQGYALPAY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGEWTAHSK TNVAHMDNDD
     FRSTEKSAVI SRKGSLRIEL KGDDGSTTVL RESVPVLDGE VVDASVMRVA ALREFLTAQV
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA KYGEVLATAG LTPNDGLGGI
     YKGLELLPEG AEIKASFDAE LAEGPELAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEHD TLAVLPDSSY AGIYQVVVDD CRAHGAYDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPAT GTVRVLDEAG EVVLEQAVGA GDIFRMCQTK DLPIRDWVKL AVTRARATGN
     PAVFWLDEDR AHDAQLIKKV KTYLGEHDTD GLQIEIMAPV HAIKFSLDRI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLAQKTD NPRAQVLADT LDRATGTFLN ENKSPSRKLG GIDNRGSHFY
     LALYWAQELA KQTEDAQLAE VFSGLAATLA EQEKTIVDEL IAVQGSPADI GGYYQPDPEK
     AAAVMRPSQT LNQALASLS
//
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