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Database: UniProt/TrEMBL
Entry: A0A1D8BWY2_9PSEU
LinkDB: A0A1D8BWY2_9PSEU
Original site: A0A1D8BWY2_9PSEU 
ID   A0A1D8BWY2_9PSEU        Unreviewed;       713 AA.
AC   A0A1D8BWY2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   28-MAR-2018, entry version 10.
DE   RecName: Full=Catalase {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
GN   ORFNames=TL08_12310 {ECO:0000313|EMBL:AOS63276.1};
OS   Actinoalloteichus hymeniacidonis.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinoalloteichus.
OX   NCBI_TaxID=340345 {ECO:0000313|EMBL:AOS63276.1, ECO:0000313|Proteomes:UP000095210};
RN   [1] {ECO:0000313|EMBL:AOS63276.1, ECO:0000313|Proteomes:UP000095210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HPA177(T) (DSM 45092(T)) {ECO:0000313|Proteomes:UP000095210};
RA   Schaffert L., Albersmeier A., Winkler A., Kalinowski J., Zotchev S.,
RA   Ruckert C.;
RT   "Complete genome sequence of the type strain Actinoalloteichus
RT   hymeniacidonis DSM 45092.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serves to protect cells from the toxic effects of
CC       hydrogen peroxide. {ECO:0000256|PIRNR:PIRNR038927}.
CC   -!- CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.
CC       {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRNR:PIRNR038927,
CC         ECO:0000256|PIRSR:PIRSR038927-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; CP014859; AOS63276.1; -; Genomic_DNA.
DR   RefSeq; WP_069848974.1; NZ_CP014859.1.
DR   EnsemblBacteria; AOS63276; AOS63276; TL08_12310.
DR   KEGG; ahm:TL08_12310; -.
DR   PATRIC; fig|340345.3.peg.2621; -.
DR   KO; K03781; -.
DR   Proteomes; UP000095210; Chromosome.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 2.40.180.10; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024712; Catalase_clade2.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002818; DJ-1/PfpI.
DR   PANTHER; PTHR42821; PTHR42821; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   Pfam; PF01965; DJ-1_PfpI; 1.
DR   PIRSF; PIRSF038927; Catalase_clade2; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095210};
KW   Heme {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|PIRSR:PIRSR038927-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|PIRSR:PIRSR038927-2, ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498, ECO:0000313|EMBL:AOS63276.1};
KW   Peroxidase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498, ECO:0000313|EMBL:AOS63276.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095210}.
FT   DOMAIN       34    423       Catalase. {ECO:0000259|SMART:SM01060}.
FT   ACT_SITE     81     81       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   ACT_SITE    155    155       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   METAL       369    369       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038927-2}.
SQ   SEQUENCE   713 AA;  78077 MW;  283D31AB2A0C71B4 CRC64;
     MANTSGPGEQ THGGDEKDQD LASARVDPAG SRLTTAQGLR VEHTDDSLRA GERGPTLLED
     FHAREKLTHF DHERIPERVV HARGSGAYGY FQPYNDVLAQ YTVAEFLRDP ARRTPVFVRF
     STVAGSRGSA DTVRDVRGFA TKFYTRQGNY DLVGNNMPVF FIQDGIKFPD FVHAVKPEPD
     NEMPQAASAH DTFWDFVGMQ PESLHMAMWL MSDRALPRSF RMMQGFGVHT FRLVDASGVG
     TFVKFHWTPR LGTHSLIWDE CQRIAGKDPD FLRRDLWNAI ASGDYPEWEL GVQLVSESDE
     FAFDFDLLDA TKLIPEELVP VQPVGRMVLT RNPQNFFAET EQVAFHTANL VPGIDFTNDP
     LLQARNFSYL DTQLIRLGGP NFSQLPVNRP IVPVHDNQRD GYAQQCIHLG RAPYHKNSID
     AGYPMVSSAS EGGYTHYQER VDGHKIRSRS GSFADHHSQA TLFWNSMAEW EREHIVAAFH
     FELGKVDRLE IRERVVAHLD HISRELAERV APGIGVTVPS GPAPTTHSRT SPALSQEGTV
     TDIVRGRSVA VLAADGVHGE SLRSLTSALS EFGLLVEVLA PHAGPLRAVG GGQASADRAM
     PTMSSVLYDA VLVADGEESA ANLRADGLAV HFVAEAVKHA KAVAAVGAGV EVLRAAPLAG
     FRFAEPGEDL VSDQGVLTSG SSPDVPPTRF LTAFAGAIAA HRTWTRAVDS IPA
//
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