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Database: UniProt/TrEMBL
Entry: A0A1D9BA06_9NEIS
LinkDB: A0A1D9BA06_9NEIS
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ID   A0A1D9BA06_9NEIS        Unreviewed;       326 AA.
AC   A0A1D9BA06;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   07-JUN-2017, entry version 5.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
DE            EC=1.1.1.37 {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
GN   Name=mdh {ECO:0000256|HAMAP-Rule:MF_01517};
GN   ORFNames=BJP62_00865 {ECO:0000313|EMBL:AOX99128.1};
OS   Jeongeupia sp. USM3.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Chromobacteriaceae; Jeongeupia.
OX   NCBI_TaxID=1906741 {ECO:0000313|EMBL:AOX99128.1, ECO:0000313|Proteomes:UP000176825};
RN   [1] {ECO:0000313|EMBL:AOX99128.1, ECO:0000313|Proteomes:UP000176825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USM3 {ECO:0000313|EMBL:AOX99128.1,
RC   ECO:0000313|Proteomes:UP000176825};
RA   Kho H.P.;
RT   "Jeongeupia sp. strain USM3 Genome sequencing and assembly.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AOX99128.1, ECO:0000313|Proteomes:UP000176825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USM3 {ECO:0000313|EMBL:AOX99128.1,
RC   ECO:0000313|Proteomes:UP000176825};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate. {ECO:0000256|HAMAP-Rule:MF_01517,
CC       ECO:0000256|SAAS:SAAS00755561}.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369698}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01517}.
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DR   EMBL; CP017668; AOX99128.1; -; Genomic_DNA.
DR   RefSeq; WP_070525587.1; NZ_CP017668.1.
DR   Proteomes; UP000176825; Chromosome.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01517; Malate_dehydrog_2; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000176825};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01517};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000176825};
KW   Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   DOMAIN        5    146       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      157    322       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   NP_BIND      11     17       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   NP_BIND     129    131       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517, ECO:0000256|PIRSR:PIRSR000102-
FT                                1}.
FT   BINDING      92     92       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING      98     98       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     105    105       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     112    112       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     131    131       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     162    162       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
SQ   SEQUENCE   326 AA;  35082 MW;  ECFF1F1E96115BE6 CRC64;
     MKKPVRVAVT GAAGQIGYSL LFRIASGAML GPDQPVILQL LDITPSLPAL NGVVMELDDC
     AFPLLQGIIQ SDDPKVAFKD ADIALLVGAR PRGPGMERKD LLEANGAIFT TQGRALNEVA
     SRDVKVLVVG NPANTNAYIA MKNAPDLNPA NFTAMMRLDH NRALTQIGQK TGNAVTDVKK
     MIIWGNHSAT QYPDIFHAEV KGQNAASLIN DQKWLESEFI PTVQQRGAAI IKARGLSSAA
     SAANAAIDHI RNWVLGTPEG DWVTMGVPAN GEYGYSDLIY GYPVTCKDGK YTIVEGLEIS
     EFSRARMDAT AKELSEERDA IKHLLG
//
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