GenomeNet

Database: UniProt/TrEMBL
Entry: A0A1I8MU29_MUSDO
LinkDB: A0A1I8MU29_MUSDO
Original site: A0A1I8MU29_MUSDO 
ID   A0A1I8MU29_MUSDO        Unreviewed;       993 AA.
AC   A0A1I8MU29;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Furin-like protease 1 {ECO:0000313|RefSeq:XP_011294848.1};
GN   Name=101893498 {ECO:0000313|EnsemblMetazoa:MDOA008443-PB};
GN   Synonyms=LOC101893498 {ECO:0000313|RefSeq:XP_011294848.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA008443-PB};
RN   [1] {ECO:0000313|RefSeq:XP_011294848.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26156588;
RA   Li D., Liang Y., Wang X., Wang L., Qi M., Yu Y., Luan Y.;
RT   "Transcriptomic Analysis of Musca domestica to Reveal Key Genes of the
RT   Prophenoloxidase-Activating System.";
RL   G3 (Bethesda) 5:1827-1841(2015).
RN   [2] {ECO:0000313|EnsemblMetazoa:MDOA008443-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA008443-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_011294848.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC       {ECO:0000256|ARBA:ARBA00005325}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_011294848.1; XM_011296546.2.
DR   STRING; 7370.A0A1I8MU29; -.
DR   EnsemblMetazoa; MDOA008443-RB; MDOA008443-PB; MDOA008443.
DR   KEGG; mde:101893498; -.
DR   VEuPathDB; VectorBase:MDOA008443; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   OrthoDB; 5474719at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00064; FU; 1.
DR   CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   PANTHER; PTHR42884:SF3; FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        108..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        933..952
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          598..727
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   REGION          215..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        308
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        349
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        523
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   993 AA;  111394 MW;  32CA931BC8AB2EEE CRC64;
     MKNDVVRWST QKRRKTYSKL CCNQENKKFP AYCAGEISYN TTFLGSSYAS GSLIQSVRCD
     TLYNNIILAE DVNKYGSTNY PERRNWHNYL NEYRHESRRH SSNRKCRSSY WSTLIFEIGI
     AIFLCSFQVS LVSCSEFESG SVIDDRSLLH ELDYADKESS FENHYTHTWA VHIPDGDMDS
     KADAVAHDNG FVNMGKIFQD HYLFAHHKVA KRSVEPSTNH QSRLDEDGRV TWSKQQIAKS
     RRKRDFIRMR PSRTSSRSAS SRVKAMPFTD PKWEHMWYLN RGGDLDMNVI PAWKEGITGK
     GIVVTILDDG LESDHPDIIN NYDPKASYDV NSHDEDPMPH YDLADSNRHG TRCAGEVAAT
     ANNSICAVGI AFGASVGGVR MLDGDVTDAV EARSLSLNPQ HIDIYSASWG PDDDGKTVDG
     PGELASRAFI EGVTKGRAGK GSIFIWASGN GGREMDNCNC DGYTNSIWTL SISSATEDGF
     VPWYSEKCSS TLATTYSSGS QAEKQVVTTD LHHSCTVSHT GTSASAPLAA GIAALVLESN
     NNLTWRDMQH IVVRTAKPAN LMDPTWSKNG VGRRVSHSFG YGLMDAAAMV KLARQWKTVP
     EQQRCEINAP HVDKVIPPKS HITLQLSVKN CLNINFLEHV QAKITLTSQR RGDIQINLIS
     PAGTKVTLLT PRVHDTSHSG FNQWPFMSVH TWGESPHGNW QLEIHNEGRY MAQITQWDLI
     FYGTEEPAQP DDPVPMATDK FNLVTAEAER NNFDYGSNSQ WRDTPKLGES GMENHDRTNT
     SCLKATINLQ CLVCAPPTFF YRGRCYDMCP THTYIARGQL HVDMTYNNLR GQAPDYEELQ
     ANDRKKRSRG AEVGETDDDG HTLNSQTAFI CEPCDKSCFN CFGPLSSECK TCYSGSQLKR
     RLNTNESYCV NFSERSSGNA IASQRSDRDY RSLLFLVFLV PSVIIILVVL LNKSEIRFNI
     CKCQRKAGIE SSVDYRYDRV SLIADEEAQE ELD
//
DBGET integrated database retrieval system