ID A0A1I8N421_MUSDO Unreviewed; 3102 AA.
AC A0A1I8N421;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Probable histone-lysine N-methyltransferase CG1716 {ECO:0000313|RefSeq:XP_011291556.1};
GN Name=101890762 {ECO:0000313|EnsemblMetazoa:MDOA011328-PB};
GN Synonyms=LOC101890762 {ECO:0000313|RefSeq:XP_011291556.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011328-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011328-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011328-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011291556.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011291556.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011291556.1; XM_011293254.2.
DR STRING; 7370.A0A1I8N421; -.
DR EnsemblMetazoa; MDOA011328-RB; MDOA011328-PB; MDOA011328.
DR GeneID; 101890762; -.
DR KEGG; mde:101890762; -.
DR VEuPathDB; VectorBase:MDOA011328; -.
DR eggNOG; KOG4442; Eukaryota.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2004..2057
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 2059..2176
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2183..2199
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2719..2752
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1776..1809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1858..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2198..2247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2277..2363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2469..2506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2537..2567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2579..2627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2749..2784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2975..2997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2835..2862
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..172
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1380..1394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1892..1917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2205..2247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2299..2331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2343..2363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2582..2626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3102 AA; 346193 MW; DC14F1965D23ED6A CRC64;
MEANNQRNKR SNARLSKGSA ACETMDSSIV PKETNECTDV AALAISPTPE GRPNPPAIIP
VSECRRSSRK KIIKFDVRDL LNKNRKPHKI QIEARIDSNV PSTSKTSAGP ANTTGVEANS
NAGSLSTGAV APADLSSKQK TFMEKSAIFR RYSISQEQTK PPPPPIPPMP PAMLNKTVGD
KDAASAILKP KHTASLIVAQ MESNVRKSAA VDAKRKTAAV TGNKTSECEP KVLDTTLVQQ
QQQQKRRGRP PKSRHQEEGD EAGKETKEVS KKLTPEKSTN CKEGDEAAEE TMEVSKKLTP
EKATNWKEYK ACLAQQSDGV GSVDDDDDDK VKSSSISEES MCPTEITNER LESGNDETSS
SMDPSTASKE IVIAMNESIA ENRMSSIEVE DERVSISPKS LNEDSVENES RKINREISLT
ESDKSDQSSE KPSSAKRSQR LQRKSKRGSI ATVKKDFSDS SENSSRESKE KPATETEPRK
EIGGGSEINQ KLADSHLKKE EQMVEIPVGN ETFNIVEIEV VETSKSPLEE MPKEVVEKYT
LEAEVSEKTE AQQHLDAPLK DKSSTDSQNS DGQTPGSEIT SKDLTPSSKE NRDADDGNQE
ETSTADTATI AKSAGRNKTK LPTTKRKSLR NRNQDKNLEE SGTVENKANE NMDNNDKVNE
ISTTKDRQAT DIEGQDQSTK SEVRLQQKEL QLDKSSSGVS QEESSATDIK EDLKKDEPVA
VTSTVETNKE EEQKTDIPNL GKRKSLRKQA KESSPDHIVV SETDNSHILK SESSSMQEVS
AEIPKRKPRK SRFRNLHGPE ETTETCGEKS DNLLKDIPTQ VMDVDVNKNE DTATSSLAEE
DVILEQRARE QSSPLGKEIL NATNETENVL PKEQKDSSQI VDVIEDQNPT IKSKDEEQVS
DKSVDVLETQ TKLSQDELLQ PTCSKSLPVQ QPMENKPSSD KTHQELEIPA NVEMQTPKEL
QQKYDIQNVS IETNTLLDIL RAVQSNKAAA IGGASNVDNV PVQLSSDTKQ QPPSNSFPSL
ETSEVEAPKG RKQHSPSNTS QSLEPPLYEV VPSKAEPAVS ENSPSSVTVP ENKSENLSDK
QVVSEHHVSP VLEKSILEAV QGENEITSKE SQKDEKSPSS ADALEENAAH KELEEGNLSK
SGKLSPATTL EEQEAKLSEP AILPPIATAS SPQNEDNSHA QKAPKISNSN SNSPNRSNTS
SPLTHKRHRN SPSRSETSSP STLRKINISP TSRSDTSSPL TFNKKITRRY ERRSRRGDDD
ETKHKTLEET FAEIAALSSK AVLVQIKGSD DNDGAPIESE IFEGEQNSQQ AILGIESQLV
VAESSRKSKS SLRSPKSKEI SNEPELTTQN AEMEIELSEA SAKSLGEDNV SNTGNKEVSS
KESTSRKSKS LGRSSKAKEQ TPQSAEIENS PPGPITKSLG ANDVPNTSSN ESSSKENLDL
ELKQVSGGLE SAENIVATEM SLDDENISRA STTPTRKSKQ TKSRSSKTQS PVSAEAGAKK
AKERNSKTER SSKTPSPQTT TTLEVVVEEK KGNGQKSKTN EIDPGNSSQD NAISGEQQGA
SSTSRASLTN IPSLEKNLNL NELAAENLPR DKENREGEII TEEIPKSTPE LSKLPPENEE
IPSQSSHKQS PGGKQNKKSN GRKNKNIDNT EVLSTANSDE AKPNTTNTPK RGRRSKSANE
KQQETPKKPT DSMAMKEKDN DTEADDKRNA NDDCENKVVG EEEEEAETST PIDEKMAKKK
RQKKLKEAFE AALNDKPLTE TAAVVETLTP SASPTFGFAL AKPNQNENTN ITVNPAVTET
DDDPPDPLKD IEKFIEDGVN LLKKGYKLDE DSVDNVIVTP SKSKADEEKI EKVIEKEVEN
EKKPESPITF NTFETPADTP LATPCVTPPP SNKSPETSLM VSTSAMEDDQ NSSGGGVRRS
HRLKLTKTTK ALVGRGLVRD KERFSIKDDV ETKSHYTLDD HLLDLAEVEA KNAKFLKEME
ERLSNFQVIK ENEYKCERVI SREARKMICD CFLTPEEEER GELACGEDCL NRLLMIECGN
ECNVKDRCTN KRFQKYLCSP CRVFRTEKKG FGIMADIEIL PGEFIMEYVG EVIDTEEFER
RRILYSQEKN RHYYFMALRS DAIIDATIKG NISRFINHSC DPNAETQKWT VNGELRIGFF
SRKSIMPGEE ITFDYQYQRY GREAQRCYCE SANCRGWIGQ EPNSDEGEQI DDEEEDEDES
DEEEEDEEER ARNLLEDDEE DSDASEVFNP EEVQKKLEMA AAQSELELAP ITLDGKAAHQ
KHLSSQVTKD SKEQGATPPK SSGEEEDSKS KFKKLLSKMA EKVAAKNKQN KREQKLQRRK
KRTKDSSSAT LEKPNKQRSL EDPDIEDEVQ FLSRCGLKTQ ADTLRLSRLM VRAKLVQTRL
HLLDILRKGE LPCRRLFLDY HGLRLLHGWM SEDAGNMQIR LALLQTLELL PIANKTVLTD
SKVMQGVRNW CGPNSNLSPN DDSQGSNSQD GTNTQAQSNT EAADSDDLQK LAQKLLSSWE
SLPEIFRIPK KERIEQMKEH EREADRQYAE TEGQNRNDHE SDQYRNDRFG RRFATASRFG
RPHNVKSMQQ QQQQQNNGGG GGNNASRPSN ILGGENANTK NLSKTQRREM FAAKVARDEA
EKRMAEERRE FETKCRFFGL DPKKTRPQEV PFCVNPATGQ WFSVERKPIN TPPSYAHVQV
PLKPKSTNPE DYQLPGVCST LPPEWKYAIT PLGQIYYYHV QYRIPQWEPP SPAQLQHSQR
HADDNDSGNE LSSTTANDST DDDDEILIGM TSEQLKAYID RKVELRRQKR YQRLVDERSI
SPRREEDRIY NQLEVRKYKE NKEKIRKRKE EIRRKRAEAL RQSSLNMCTL GSLASEGGLA
SASSSSVKSE NEEDSGVIPI QDYLLSSDED DDLKSEINSP LIDKIVEGDK IVDELDALTT
KRQLKRPLPS HRDFNDQWSS SSSSVAAAAA LADRQEYKKR KMEKKDKRKP KEQDAKYRRN
KEKFRCEIAG IIVHHLKPYR RDNCTVGRIT SNEDFNHLAR KLTHFVMIKE LKYCESVGQT
LVVTESVKNK SREFIKKYMA KYGEVYVKPA NDPEFKDIPF TL
//