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Database: UniProt/TrEMBL
Entry: A0A1P8TNV8_9ACTN
LinkDB: A0A1P8TNV8_9ACTN
Original site: A0A1P8TNV8_9ACTN 
ID   A0A1P8TNV8_9ACTN        Unreviewed;       739 AA.
AC   A0A1P8TNV8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   20-DEC-2017, entry version 6.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:APY89224.1};
GN   ORFNames=A7J05_29155 {ECO:0000313|EMBL:APY89224.1};
OS   Streptomyces silaceus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=545123 {ECO:0000313|EMBL:APY89224.1, ECO:0000313|Proteomes:UP000187191};
RN   [1] {ECO:0000313|EMBL:APY89224.1, ECO:0000313|Proteomes:UP000187191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACCC40021 {ECO:0000313|EMBL:APY89224.1,
RC   ECO:0000313|Proteomes:UP000187191};
RA   Lavstsen T., Jespersen J.S.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP015588; APY89224.1; -; Genomic_DNA.
DR   RefSeq; WP_076687069.1; NZ_CP015588.1.
DR   Proteomes; UP000187191; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000187191};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   COILED      226    246       {ECO:0000256|SAM:Coils}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79070 MW;  64CD92118E71F4D1 CRC64;
     MTDSTIIYTH TDEAPALATH SFLPVVQAYA STAGVSVETR DISLAGRIIA SFPERLDEGQ
     RINDALAELG ELAKTPQANI IKLPNISASI PQLKAAIAEL QGQGYALPDY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWTADSK TNVATMGEND
     FRSTEKSAVI SEAGSLRIEL TGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLKEQV
     ARAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA AYGDVLAAAG LTPNDGLGGI
     FKGLDSLADG EKIKASFEAE LAEGPELAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGAEHD TLAVLPDSSY AGIYQVVIDD CRANGAFDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPAT GTVRVVDGAG EVVLEQTVAA GDIFRMCQTK DAPIQDWVKL AVTRARATGS
     PAVFWLDESR AHDAVLIGKV ERYLADHETE GLDIRVMSPV EATAFSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLATTTG NARAQILADT LDRATATFLE NDKSPSRRLG GIDNRGSHFY
     LGLYWAQELA KQTEDAELAE AFAALAKTLS EQEQAIVDEL IAVQGSPADI GGYYQPDAAK
     ASAVMRPSAT LNQALSILG
//
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