ID A0A1P8Y2K9_9ACTN Unreviewed; 3700 AA.
AC A0A1P8Y2K9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AQA14647.1};
GN ORFNames=BV401_33785 {ECO:0000313|EMBL:AQA14647.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:AQA14647.1, ECO:0000313|Proteomes:UP000187851};
RN [1] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP019458; AQA14647.1; -; Genomic_DNA.
DR STRING; 75293.BV401_33785; -.
DR KEGG; sauo:BV401_33785; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..438
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 945..1020
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1037..1461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1960..2035
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2060..2485
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3523..3598
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 920..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3602..3626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3700 AA; 385692 MW; 2A7538183F69468A CRC64;
MSTVADSPWQ HAVHDSIAVI GFSCRLPRAA TPGEFWRLLS DGEDAITSVP EDRWTPRQSG
GRSGAGAEAG MEFGAFLDRV DHFDADFFGI SPREAGAMDP QQRLMLELGW ETLEDAGLTP
ARIAHGRTGV FVGAVNDDYA ILLRRHGNSA VTHHTLTGLQ RGMIANRLSY LLGTRGPSMV
VDSGQSSSLV AVHTAAQSLR SGECDTALAG GVHLNLAYDG ALSAARFGGL SPDGRCFAFD
ARANGFVRGE GGGLVLLKPL ARALADGDRI HGVLRGGAVN NDGGGDTLTT PSRTAQAEVL
RQAYAAAGVG PDEVQYVELH GTGTAVGDPI EAAALAEVIG AARTKDRPLL VGSAKTNVGH
LEGAAGITGL IKVLLSLEAA RLPPSLNFSS PNPAIPLAEW NLRVQTGLSA WPRPDAPLIA
GVSSFGVGGT NAHVVVEQAP VARPAKGAAD VPQGVGRDMA QDIGRDVAEG VAVAGARGDE
VRVPLPWVVS GRSAAGVRAQ AARLREFAAD GQSSPADIGW SLAEHRTALE HRAVVVAGDR
EGFLAGLDAL ASGEPFAHVV DGVAAEPVPG PVFVFPGQGS QWVGMAAELL DVSPVFAESI
DRCARALAPH TGWDLLGVLR ETEDGAALER AEVLQPALWA VMVSLTRVWR SLGVVPSAVV
GHSQGEIAAA CAAGALSLED GARLIAVRSR LAEALIGRGG LVSIGASAER TAELFADRDD
VWIAAVNGPG ATVVGGGLEG LAEVTAGAEA AGLRHRTVAT AYASHTPHVE AIREEFLRLA
APIAPRTGDV PMYSTVTTAP IAGESLDAEY WYRNLREQVR FHDTVQNLIA DGNSLFLESS
SHPVLTAAVQ ETGGLAVGTL RRGEGGTRRL LLSLAQLWVH GAAPDWAKVF AGTGARRTEL
PGRAFQRRRH WFDTMATGAA ADTAPGATGG TEDPGALGAP GASGPDVAHQ VRAQAAAVLG
HTTAAELDTG RTFKDLGFDS ISLSDLCSRI NTALGTRLSP AALFSHPTPA RLAEHLAATG
PATVDRPSEP ATATTTDEPI AIIAMSCRLP GGVGSPEDLW RLVADGRDAI SPFPDDRGWD
LERLHGTEGA GSSFAQGGGF IDGATDFDAR FFGISPREAL AMDPQQRLLL ETSWELLERA
GIDPGALRAT RTGVFVGTMD QEYGPRLHEA PEAVDGYLLT GRTASVASGR IAYLLGLTGP
AITLDTACSS SLVALHLAVQ SLRRGESSLA LVGGVTVLNT PGIFTEFSRQ GGLARDGRCK
AFAAGADGTG MAEGVGMLLV ERLSDAHRNG HRVLGVIRGT AVNQDGASNG LTAPNGLSQE
QVVRQALADA GVAASDVDVV EAHGTGTALG DPIEAQALLA TYGRNRPAER PALLGSVKSN
IGHTQAAAGV AGVIKTIMAM RHGVVPATLH VDEPTPHVDW ARGGVELVTE GRPWPEAGRA
RRAGVSSFGI SGTNAHVVLE EAPPAAVPSV GVRPATSAIR VEGVLPWVVS GRSPAALRAQ
AARLRAFAGV CDATPSDIGW ALATRRAALE HRAVVVAGDR NEFLAGLDAI ASGEAANQVI
GGAVRGAPGT GPVFVFPGQG SQWVGMAAEL LDSAPVFAES IDRAAQALAP HIDWDLLDVL
RATGDDTALE RVDVVQPALW AVMVSLARVW RAWGVEPSAV VGHSQGEIAA ACVAGVLSLE
DGARLVALRS RVIARELAGH GGMVSLATSA DRTHELLTGR DDIWIAAVNG PAATVIAGSP
SGLAEITAHA EAMGVRARTI PVDYASHTPH VERVRERLLQ LAAPITPRAG DVPMYSTVTA
APIAGEALDA EYWYRNLREQ VRFQDTLQTL LADGHALFLE SSAHPVLTTA VEETGHATDQ
RILATGTLRR DHGGVRQLLG ALAALWAHGV DPDWTAVFTP GGATAVDLPT YAFQRERYWL
APVGPASAVR VDLPSVVTAE ALDGFARRVA DTAEGAPRLR VALDEVRRHA AAVLGLSSVD
EVETRKVFRD LGFDSLTAVE LRNRLAVATG AALAPSAVFD YPTPLALAGH LLDRITGGDT
AGVGPYATGA VVADVAAALD EPIAIVATSC RFPAGVRSPE ELWQLLLSEQ DTLSAFPADR
GWDLDALYHP DPERPGSSYV HQGGFLQDAA DFDAAFFGIS PREAMAMDPQ QRLLLETSWE
ALEHAGIDPL SLHGSRTGVF IGLVPHGYGG EGADTTGAEG YLFTGAAGSV ASGRVAYSLG
LTGPAVTVDT ACSSSLVALH LAVQALRNGE CGMALVGGVS VMSTPGVFTE FSHQRGLAPD
GHCKPFAAAA DGTAWAEGVG VLLVERLSAA RRNGHQVLAV IRGSAINQDG ASNGLTAPNG
PSQQAVIRQA LANARLTPSD VDVIEAHGTG TALGDPIEAQ ALLATYGQGR STEHPALLGS
MKAHIGHTGA AAGVASVIKM VLALRHGVVP RTLHVDEPTP HVDWASGAVR LVTENAPWPE
AERARRAAVS SFGVSGTNVH VILEAAPPAE TVSEESAPTE GVLPWVISAR SEAALRAQAA
QLRTYAATAD RHLADIGWTL ARHRAALEHR AVVIATDRDT FLTGLDAIAS GEPATHVTSG
TAPGEPPSGA VFVFPGQGSQ WVGMAAELLA TSPVFAESID RCAQVLAPHI EWNLLDVLRA
TGDDALERVD VVQPALWAVM VSLARVWRSL GIEPAAVIGH SQGEIAAACV AGALSLEDGA
RLIALRSRLI AEELAGHGGM VSLGTSADQT HELLTGRDDI WIATVNGPTT TVIAGDPAAL
TDVMAQAEAT GIRARTIAVD YASHTPHVER IREQLRQLAA PMTPRAGDVP MYSTVTAAPI
DGEALDAEYW YRNLREHVRF HDTIRTLVAD GHTVFLEAGP HPVLTTAIEE TGAHATGTLR
RENGGIRQLL TSLATLWTHG LTPDWSALLT PNTPTPADLP TYPFQRHRYW LDAAAPGRHR
ATAGPDAHTG FWEVVEREDV EGLARTLRLE GSQTELTTLL PALSAWHRRQ SAAATMDAWR
YREGWRPLPE TTAPALSGIW LVVLAPDQKG GAPHEAIATA LARHGATVET VVVAPDDPRH
WADTLTAHAT APVAGVLSLL ARDEAAGLHH TVRLVQGLEA AGVSAPLWCV TQGAVSVGDH
DPLTGPAQAL VWGLGRVAAQ ELATRWGGLV DLPRELDERT TTRLCAVLAA DGHEDEGTVH
EDQVTGHEGQ VAAHEDQVAV RAAGVLGRRI VRAPRLAEVP DDGWTPGPGT VLITGGTGAL
GSQVARRLAA RGAEHLLLVS RRGDTAPGAA ELVAELTASG AKATVAACDV GDPDAIRALL
GSIPSAYPLT SVFHTAAVLD DAAIGSLAPE QVDRVLRVKA DAAWRLHELT QGLELSAFVL
FSSLAGTVGM VGQGNYAPAN AYMDALARHR RARGLVATSV AWGSWAQGGM AERDAVTELR
LRHGVPLLPP ESAILALEAA LADDETALVI ADIDWDRFAH AYTAARPSPL LDEIPEARRA
LGTVDGAGAG APGGGMSGTG GAGGTVANLR DRLADAKPEE RERRLLDAVR GQVAAVLGHD
SADDVGTRRQ FLELGLDSVT AVELRNRLGN ITGLRLPATL IFDFPTVTEL VGYLSTQLFT
GIGDGPDGSG PDGSGPHDNA PAATGDGTAE LDRLERLLGT LSNDAPARSE IADRLRRLLR
SAVDSTDAMD TADDPATSED LEAATNDELF DYIEKEFGIS
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