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Database: UniProt/TrEMBL
Entry: A0A1Q2CCG9_9ACTN
LinkDB: A0A1Q2CCG9_9ACTN
Original site: A0A1Q2CCG9_9ACTN 
ID   A0A1Q2CCG9_9ACTN        Unreviewed;       737 AA.
AC   A0A1Q2CCG9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   30-AUG-2017, entry version 5.
DE   SubName: Full=Isocitrate dehydrogenase (NADP(+)) {ECO:0000313|EMBL:AQP43812.1};
GN   ORFNames=RPIT_02410 {ECO:0000313|EMBL:AQP43812.1};
OS   Tessaracoccus flavus.
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Tessaracoccus.
OX   NCBI_TaxID=1610493 {ECO:0000313|EMBL:AQP43812.1, ECO:0000313|Proteomes:UP000188324};
RN   [1] {ECO:0000313|EMBL:AQP43812.1, ECO:0000313|Proteomes:UP000188324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RP1T {ECO:0000313|EMBL:AQP43812.1,
RC   ECO:0000313|Proteomes:UP000188324};
RX   PubMed=26869509; DOI=10.1099/ijsem.0.000958;
RA   Kumari R., Singh P., Schumann P., Lal R.;
RT   "Tessaracoccus flavus sp. nov., isolated from the drainage system of a
RT   lindane-producing factory.";
RL   Int. J. Syst. Evol. Microbiol. 66:1862-1868(2016).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP019605; AQP43812.1; -; Genomic_DNA.
DR   Proteomes; UP000188324; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000188324};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000188324}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       346    346       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       544    544       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     543    543       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        416    416       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   737 AA;  79266 MW;  2CE2C5B605DEB4B2 CRC64;
     MGKIIYTLTD EAPLLATYSF LPIVESFAGQ AGVDVETRDI SLAGRILAQF ADRLPAEQQV
     DDALSELGEL AKTPEANIIK LPNISASVPQ LKAAITELQA QGFALPDYPE DPQTDEDRET
     RARYDRVKGS AVNPVLREGN SDRRAPESVK NYAKKNPHRM GAWDAGSKTA VATMDEGDFR
     HNEQSVVLPA ADVLTIRHRA ADGTETILKD GLKVLADEVV DATVMRAAAL DDFLRNQVAA
     AKDSGVLFSV HLKATMMKVS DPIIFGHVIR AFFPAVFEQY GADLAAAGLS PNDGLGAILA
     GLDALPNGAE IRAAFEQGLA DGPELAMVNS DKGITNLHVP SDVIVDASMP AMIRQSGHMW
     GPDGEEADTL AVLPDSSYAG VYQAVIEDCK ANGAFDPTTM GTVPNVGLMA QKAEEYGSHD
     KTFEMKADGV VEVVNSAGDV LMSHEVGAGD IWRACQAKDA PIQDWVKLAV SRASATGWPA
     VFWLDPERAH DLNLIEKVKT YLADHDTEGL TIEILSPVEA TKYTIERLRR GENTISVTGN
     VLRDYLTDLF PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENYLRWDSL
     GEFLALAASF EHLAQAEGND RAGVLATTLD RATGQFLDND KSPTRRLGGV DNRGSHYWLA
     RYWAEELATQ SDDARLAEIF RPVADALTEA EETIVSELIA VQGSPADIGG YFRPDDQKAA
     AVMRPSATFN QIIDSIG
//
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