ID   A0A1R3TD18_9BACT        Unreviewed;       542 AA.
AC   A0A1R3TD18;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Exo-alpha-sialidase {ECO:0000313|EMBL:SCD21895.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:SCD21895.1};
GN   Name=nanH {ECO:0000313|EMBL:SCD21895.1};
GN   ORFNames=PSM36_3106 {ECO:0000313|EMBL:SCD21895.1};
OS   Proteiniphilum saccharofermentans.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC   Proteiniphilum.
OX   NCBI_TaxID=1642647 {ECO:0000313|EMBL:SCD21895.1, ECO:0000313|Proteomes:UP000187464};
RN   [1] {ECO:0000313|EMBL:SCD21895.1, ECO:0000313|Proteomes:UP000187464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3/6 {ECO:0000313|EMBL:SCD21895.1};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LT605205; SCD21895.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R3TD18; -.
DR   STRING; 1642647.PSM36_3106; -.
DR   KEGG; psac:PSM36_3106; -.
DR   Proteomes; UP000187464; Chromosome i.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:SCD21895.1};
KW   Hydrolase {ECO:0000313|EMBL:SCD21895.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187464};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..542
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012751671"
FT   DOMAIN          20..170
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          203..483
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   542 AA;  60006 MW;  1C806610C3B5303C CRC64;
     MKRIILSFLL ACFIFTIQAT DTIYIKQTKI PVLIDRLDNV LFYVRIDARN SKTLDEIKLR
     FAEDTHPDEI ASVKLYYGGT EAPERLGNIH YAPVQYISSH NAQGKTREAI PSYSIKVNEQ
     QSPSGEVVFK PEYKLFPGIN YFWVSLQMKP NTSLLSTVGV DLVSAKLDGK NAPVTSQDKP
     AAHRMGIGVR HAGDDGAAAY RIPGLATSNK GSLLAVYDVR YNNSVDLQEY IDVGLSRSTD
     KGQSWEEMRL PLSFGEYGGL PKAQNGVGDP AILVDTKSGT IWIIALWTHG MGNRRAWHNS
     QAGMDINETG QLVLTKSTDD GKTWSDPINI TQQVKDPSWR LLLQGPGRGI TMQDGTLVFP
     IQFIDSTSVP FAGIMYSKDS GETWKIHNPA RSNTTEAQVA ETAPGVLMLN MRDNRGGSRA
     VSTTGDLGLT WTEHPSSRKV LQEPVCMASL LQVDAKDNVL NRDILLFSNP NSTKERNKIT
     IKASLDGGIS FPEEYQLLLD EDHGWGYSCL TMIDKETIGI IYESSVAHMT FQAIKLTDII
     RK
//